3W51

Tankyrase in complex with 2-hydroxy-4-methylquinoline

Summary for 3W51

• Entry DOI: 10.2210/pdb3w51/pdb
• Related: 4IUE
• Descriptor: Tankyrase-2, 4-methylquinolin-2-ol, ZINC ION, ... (5 entities in total)
• Functional Keywords: ribosylation, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q9H2K2
• Total number of polymer chains: 2
• Total formula weight: 48819.83

Authors

Jansson, A.E.,Larsson, E.A.,Nordlund, P.L. (deposition date: 2013-01-18, release date: 2013-07-10, Last modification date: 2023-11-08)

• Primary citation: Larsson, E.A.,Jansson, A.E.,Ng, F.M.,Then, S.W.,Panicker, R.,Liu, B.,Sangthongpitag, K.,Pendharkar, V.,Tai, S.J.,Hill, J.,Dan, C.,Ho, S.Y.,Cheong, W.W.,Poulsen, A.,Blanchard, S.,Lin, G.R.,Alam, J.,Keller, T.H.,Nordlund, P.; Fragment-based ligand design of novel potent inhibitors of tankyrases.; J.Med.Chem., 56:4497-4508, 2013; PubMed: 23672613; DOI: 10.1021/jm400211f

Experimental method

X-RAY DIFFRACTION (2 Å)