4J1Z

Tankyrase 2 in complex with 4-chloro-1,2-dihydrophatalzin-one

Summary for 4J1Z

• Entry DOI: 10.2210/pdb4j1z/pdb
• Related: 4J21 4J22
• Descriptor: Tankyrase-2, ZINC ION, SULFATE ION, ... (5 entities in total)
• Functional Keywords: catalytic fragment, parp, adp-ribosylation, ank repeat, glycosyltransferase, membrane, mrna transport, nad, telomere, transferase, translocation, wnt-signalling, ribosylation
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q9H2K2
• Total number of polymer chains: 2
• Total formula weight: 48862.64

Authors

Jansson, A.E. (deposition date: 2013-02-03, release date: 2013-07-10, Last modification date: 2023-11-08)

• Primary citation: Larsson, E.A.,Jansson, A.E.,Ng, F.M.,Then, S.W.,Panicker, R.,Liu, B.,Sangthongpitag, K.,Pendharkar, V.,Tai, S.J.,Hill, J.,Dan, C.,Ho, S.Y.,Cheong, W.W.,Poulsen, A.,Blanchard, S.,Lin, G.R.,Alam, J.,Keller, T.H.,Nordlund, P.; Fragment-based ligand design of novel potent inhibitors of tankyrases.; J.Med.Chem., 56:4497-4508, 2013; PubMed: 23672613; DOI: 10.1021/jm400211f

Experimental method

X-RAY DIFFRACTION (2 Å)