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4TZ4
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BU of 4tz4 by Molmil
Crystal Structure of Human Cereblon in Complex with DDB1 and Lenalidomide
分子名称: DNA damage-binding protein 1, Protein cereblon, S-Lenalidomide, ...
著者Chamberlain, P.P, Pagarigan, B, Delker, S, Leon, B, Riley, M.
登録日2014-07-09
公開日2014-08-06
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.01 Å)
主引用文献Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
To Be Published
4OTI
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BU of 4oti by Molmil
Crystal Structure of PRK1 Catalytic Domain in Complex with Tofacitinib
分子名称: 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile, Serine/threonine-protein kinase N1
著者Chamberlain, P.P, Delker, S, Pagarigan, B, Mahmoudi, A, Jackson, P, Abbassian, M, Muir, J, Raheja, N, Cathers, B.
登録日2014-02-13
公開日2014-08-27
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Crystal Structures of PRK1 in Complex with the Clinical Compounds Lestaurtinib and Tofacitinib Reveal Ligand Induced Conformational Changes.
Plos One, 9, 2014
4TZC
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BU of 4tzc by Molmil
Crystal Structure of Murine Cereblon in Complex with Thalidomide
分子名称: Protein cereblon, S-Thalidomide, SULFATE ION, ...
著者Chamberlain, P.P, Pagarigan, B, Delker, S, Leon, B.
登録日2014-07-10
公開日2014-08-06
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
to be published
5HXB
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BU of 5hxb by Molmil
Cereblon in complex with DDB1, CC-885, and GSPT1
分子名称: 1-(3-chloro-4-methylphenyl)-3-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)urea, DNA damage-binding protein 1, Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, ...
著者Chamberlain, P.P, Matyskiela, M, Pagarigan, B.
登録日2016-01-30
公開日2016-06-29
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.
Nature, 535, 2016
5V3O
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BU of 5v3o by Molmil
Cereblon in complex with DDB1 and CC-220
分子名称: (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, DNA damage-binding protein 1, Protein cereblon, ...
著者Matyskiela, M, Pagarigan, B, Chamberlain, P.
登録日2017-03-07
公開日2017-05-03
最終更新日2018-02-07
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos.
J. Med. Chem., 61, 2018
4OTG
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BU of 4otg by Molmil
Crystal Structure of PRK1 Catalytic Domain in Complex with Lestaurtinib
分子名称: Lestaurtinib, Serine/threonine-protein kinase N1
著者Chamberlain, P.P, Delker, S, Pagarigan, B, Mahmoudi, A, Jackson, P, Abbassian, M, Muir, J, Raheja, N, Cathers, B.
登録日2014-02-13
公開日2014-08-27
最終更新日2022-12-07
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal Structures of PRK1 in Complex with the Clinical Compounds Lestaurtinib and Tofacitinib Reveal Ligand Induced Conformational Changes.
Plos One, 9, 2014
4OTH
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BU of 4oth by Molmil
Crystal Structure of PRK1 Catalytic Domain in Complex with Ro-31-8220
分子名称: BISINDOLYLMALEIMIDE IX, Serine/threonine-protein kinase N1
著者Chamberlain, P.P, Delker, S, Pagarigan, B, Mahmoudi, A, Jackson, P, Abbassian, M, Muir, J, Raheja, N, Cathers, B.
登録日2014-02-13
公開日2014-08-27
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal Structures of PRK1 in Complex with the Clinical Compounds Lestaurtinib and Tofacitinib Reveal Ligand Induced Conformational Changes.
Plos One, 9, 2014
4OTD
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BU of 4otd by Molmil
Crystal Structure of PRK1 Catalytic Domain
分子名称: Serine/threonine-protein kinase N1
著者Chamberlain, P.P, Delker, S, Pagarigan, B, Mahmoudi, A, Jackson, P, Abbassian, M, Muir, J, Raheja, N, Cathers, B.
登録日2014-02-13
公開日2014-08-27
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structures of PRK1 in Complex with the Clinical Compounds Lestaurtinib and Tofacitinib Reveal Ligand Induced Conformational Changes.
Plos One, 9, 2014
4TZU
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BU of 4tzu by Molmil
Crystal Structure of Murine Cereblon in Complex with Pomalidomide
分子名称: Protein cereblon, S-Pomalidomide, SULFATE ION, ...
著者Chamberlain, P.P, Pagarigan, B, Delker, S, Leon, B.
登録日2014-07-10
公開日2014-08-06
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
to be published
6UML
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BU of 6uml by Molmil
Structural Basis for Thalidomide Teratogenicity Revealed by the Cereblon-DDB1-SALL4-Pomalidomide Complex
分子名称: DNA damage-binding protein 1, Protein cereblon, S-Pomalidomide, ...
著者Clayton, T.L, Matyskiela, M.E, Pagarigan, B.E, Tran, E.T, Chamberlain, P.P.
登録日2019-10-09
公開日2020-04-15
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.58 Å)
主引用文献Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex.
Nat.Struct.Mol.Biol., 27, 2020
4WNM
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BU of 4wnm by Molmil
SYK catalytic domain in complex with a potent triazolopyridine inhibitor
分子名称: N~3~-(tetrahydro-2H-pyran-4-yl)-N~6~-[5-(tetrahydro-2H-pyran-4-ylmethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-1H-indazole-3,6-diamine, SULFATE ION, Tyrosine-protein kinase SYK
著者Jackson, P.J.
登録日2014-10-13
公開日2016-01-20
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A Novel Triazolopyridine-Based Spleen Tyrosine Kinase Inhibitor That Arrests Joint Inflammation.
Plos One, 11, 2016
1MDZ
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BU of 1mdz by Molmil
Crystal structure of ArnB aminotransferase with cycloserine and pyridoxal 5' phosphate
分子名称: ArnB aminotransferase, D-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-N,O-CYCLOSERYLAMIDE, PYRIDOXAL-5'-PHOSPHATE
著者Noland, B.W, Newman, J.M, Hendle, J, Badger, J, Christopher, J.A, Tresser, J, Buchanan, M.D, Wright, T, Rutter, M.E, Sanderson, W.E, Muller-Dieckmann, H.-J, Gajiwala, K.S, Sauder, J.M, Buchanan, S.G.
登録日2002-08-07
公開日2002-12-11
最終更新日2018-12-26
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Structural studies of Salmonella typhimurium ArnB (PmrH) aminotransferase: A 4-amino-4-deoxy-L-arabinose lipopolysaccharide modifying enzyme
Structure, 10, 2002
1MDX
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BU of 1mdx by Molmil
Crystal structure of ArnB transferase with pyridoxal 5' phosphate
分子名称: 2-OXOGLUTARIC ACID, ArnB aminotransferase, GLYCEROL, ...
著者Noland, B.W, Newman, J.M, Hendle, J, Badger, J, Christopher, J.A, Tresser, J, Buchanan, M.D, Wright, T.A, Rutter, M.E, Sanderson, W.E, Muller-Dieckmann, H.-J, Gajiwala, K.S, Sauder, J.M, Buchanan, S.G.
登録日2002-08-07
公開日2002-12-11
最終更新日2018-12-26
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Structural studies of Salmonella typhimurium ArnB (PmrH) aminotransferase: A 4-amino-4-deoxy-L-arabinose lipopolysaccharide modifying enzyme
Structure, 10, 2002
1VHA
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BU of 1vha by Molmil
Crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
分子名称: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ACETIC ACID, MANGANESE (II) ION, ...
著者Structural GenomiX
登録日2003-12-01
公開日2003-12-30
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural analysis of a set of proteins resulting from a bacterial genomics project
Proteins, 60, 2005
1VHU
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BU of 1vhu by Molmil
Crystal structure of a putative phosphoesterase
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Hypothetical protein AF1521
著者Structural GenomiX
登録日2003-12-01
公開日2003-12-30
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.34 Å)
主引用文献Structural analysis of a set of proteins resulting from a bacterial genomics project
Proteins, 60, 2005
1VI5
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BU of 1vi5 by Molmil
Crystal structure of ribosomal protein S2P
分子名称: 30S ribosomal protein S2P
著者Structural GenomiX
登録日2003-12-01
公開日2003-12-30
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structural analysis of a set of proteins resulting from a bacterial genomics project
Proteins, 60, 2005
1VH6
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BU of 1vh6 by Molmil
Crystal structure of a flagellar protein
分子名称: Flagellar protein fliS
著者Structural GenomiX
登録日2003-12-01
公開日2003-12-30
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural analysis of a set of proteins resulting from a bacterial genomics project
Proteins, 60, 2005
1VHK
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BU of 1vhk by Molmil
Crystal structure of an hypothetical protein
分子名称: Hypothetical protein yqeU
著者Structural GenomiX
登録日2003-12-01
公開日2003-12-30
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural analysis of a set of proteins resulting from a bacterial genomics project
Proteins, 60, 2005
1VHG
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BU of 1vhg by Molmil
Crystal structure of ADP compounds hydrolase
分子名称: ADP compounds hydrolase nudE
著者Structural GenomiX
登録日2003-12-01
公開日2003-12-30
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural analysis of a set of proteins resulting from a bacterial genomics project
Proteins, 60, 2005
1VHT
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BU of 1vht by Molmil
Crystal structure of dephospho-coA kinase with bis(adenosine)-5'-triphosphate
分子名称: ACETATE ION, BIS(ADENOSINE)-5'-TRIPHOSPHATE, Dephospho-CoA kinase
著者Structural GenomiX
登録日2003-12-01
公開日2003-12-30
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Structural analysis of a set of proteins resulting from a bacterial genomics project
Proteins, 60, 2005
1VI9
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BU of 1vi9 by Molmil
Crystal structure of pyridoxamine kinase
分子名称: BETA-MERCAPTOETHANOL, Pyridoxamine kinase, SULFATE ION
著者Structural GenomiX
登録日2003-12-01
公開日2003-12-30
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Structural analysis of a set of proteins resulting from a bacterial genomics project
Proteins, 60, 2005
1VH2
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BU of 1vh2 by Molmil
Crystal structure of a autoinducer-2 synthesis protein
分子名称: S-ribosylhomocysteinase, ZINC ION
著者Structural GenomiX
登録日2003-12-01
公開日2003-12-30
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural analysis of a set of proteins resulting from a bacterial genomics project
Proteins, 60, 2005
1VH9
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BU of 1vh9 by Molmil
Crystal structure of a putative thioesterase
分子名称: Hypothetical protein ybdB
著者Structural GenomiX
登録日2003-12-01
公開日2003-12-30
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural analysis of a set of proteins resulting from a bacterial genomics project
Proteins, 60, 2005
7MYZ
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BU of 7myz by Molmil
Structure of the full length 5-TM receptor CD47 bound to Fab B6H12
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, B6H12 Fab heavy chain, B6H12 Fab light chain, ...
著者Fenalti, G, Villanueva, N.
登録日2021-05-22
公開日2021-09-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structure of the human marker of self 5-transmembrane receptor CD47.
Nat Commun, 12, 2021
3WX2
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BU of 3wx2 by Molmil
Mouse Cereblon thalidomide binding domain, native
分子名称: Protein cereblon, SULFATE ION, ZINC ION
著者Mori, T, Ito, T, Hirano, Y, Yamaguchi, Y, Handa, H, Hakoshima, T.
登録日2014-07-10
公開日2014-08-06
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs
Nat.Struct.Mol.Biol., 21, 2014

 

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