4TZ4
| Crystal Structure of Human Cereblon in Complex with DDB1 and Lenalidomide | 分子名称: | DNA damage-binding protein 1, Protein cereblon, S-Lenalidomide, ... | 著者 | Chamberlain, P.P, Pagarigan, B, Delker, S, Leon, B, Riley, M. | 登録日 | 2014-07-09 | 公開日 | 2014-08-06 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | 主引用文献 | Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex To Be Published
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4TZU
| Crystal Structure of Murine Cereblon in Complex with Pomalidomide | 分子名称: | Protein cereblon, S-Pomalidomide, SULFATE ION, ... | 著者 | Chamberlain, P.P, Pagarigan, B, Delker, S, Leon, B. | 登録日 | 2014-07-10 | 公開日 | 2014-08-06 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex to be published
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4TZC
| Crystal Structure of Murine Cereblon in Complex with Thalidomide | 分子名称: | Protein cereblon, S-Thalidomide, SULFATE ION, ... | 著者 | Chamberlain, P.P, Pagarigan, B, Delker, S, Leon, B. | 登録日 | 2014-07-10 | 公開日 | 2014-08-06 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex to be published
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5HXB
| Cereblon in complex with DDB1, CC-885, and GSPT1 | 分子名称: | 1-(3-chloro-4-methylphenyl)-3-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)urea, DNA damage-binding protein 1, Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, ... | 著者 | Chamberlain, P.P, Matyskiela, M, Pagarigan, B. | 登録日 | 2016-01-30 | 公開日 | 2016-06-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase. Nature, 535, 2016
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5V3O
| Cereblon in complex with DDB1 and CC-220 | 分子名称: | (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, DNA damage-binding protein 1, Protein cereblon, ... | 著者 | Matyskiela, M, Pagarigan, B, Chamberlain, P. | 登録日 | 2017-03-07 | 公開日 | 2017-05-03 | 最終更新日 | 2018-02-07 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos. J. Med. Chem., 61, 2018
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4OTI
| Crystal Structure of PRK1 Catalytic Domain in Complex with Tofacitinib | 分子名称: | 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile, Serine/threonine-protein kinase N1 | 著者 | Chamberlain, P.P, Delker, S, Pagarigan, B, Mahmoudi, A, Jackson, P, Abbassian, M, Muir, J, Raheja, N, Cathers, B. | 登録日 | 2014-02-13 | 公開日 | 2014-08-27 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Crystal Structures of PRK1 in Complex with the Clinical Compounds Lestaurtinib and Tofacitinib Reveal Ligand Induced Conformational Changes. Plos One, 9, 2014
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4OTH
| Crystal Structure of PRK1 Catalytic Domain in Complex with Ro-31-8220 | 分子名称: | BISINDOLYLMALEIMIDE IX, Serine/threonine-protein kinase N1 | 著者 | Chamberlain, P.P, Delker, S, Pagarigan, B, Mahmoudi, A, Jackson, P, Abbassian, M, Muir, J, Raheja, N, Cathers, B. | 登録日 | 2014-02-13 | 公開日 | 2014-08-27 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal Structures of PRK1 in Complex with the Clinical Compounds Lestaurtinib and Tofacitinib Reveal Ligand Induced Conformational Changes. Plos One, 9, 2014
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4OTG
| Crystal Structure of PRK1 Catalytic Domain in Complex with Lestaurtinib | 分子名称: | Lestaurtinib, Serine/threonine-protein kinase N1 | 著者 | Chamberlain, P.P, Delker, S, Pagarigan, B, Mahmoudi, A, Jackson, P, Abbassian, M, Muir, J, Raheja, N, Cathers, B. | 登録日 | 2014-02-13 | 公開日 | 2014-08-27 | 最終更新日 | 2022-12-07 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal Structures of PRK1 in Complex with the Clinical Compounds Lestaurtinib and Tofacitinib Reveal Ligand Induced Conformational Changes. Plos One, 9, 2014
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4OTD
| Crystal Structure of PRK1 Catalytic Domain | 分子名称: | Serine/threonine-protein kinase N1 | 著者 | Chamberlain, P.P, Delker, S, Pagarigan, B, Mahmoudi, A, Jackson, P, Abbassian, M, Muir, J, Raheja, N, Cathers, B. | 登録日 | 2014-02-13 | 公開日 | 2014-08-27 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structures of PRK1 in Complex with the Clinical Compounds Lestaurtinib and Tofacitinib Reveal Ligand Induced Conformational Changes. Plos One, 9, 2014
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4WNM
| SYK catalytic domain in complex with a potent triazolopyridine inhibitor | 分子名称: | N~3~-(tetrahydro-2H-pyran-4-yl)-N~6~-[5-(tetrahydro-2H-pyran-4-ylmethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-1H-indazole-3,6-diamine, SULFATE ION, Tyrosine-protein kinase SYK | 著者 | Jackson, P.J. | 登録日 | 2014-10-13 | 公開日 | 2016-01-20 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | A Novel Triazolopyridine-Based Spleen Tyrosine Kinase Inhibitor That Arrests Joint Inflammation. Plos One, 11, 2016
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6UML
| Structural Basis for Thalidomide Teratogenicity Revealed by the Cereblon-DDB1-SALL4-Pomalidomide Complex | 分子名称: | DNA damage-binding protein 1, Protein cereblon, S-Pomalidomide, ... | 著者 | Clayton, T.L, Matyskiela, M.E, Pagarigan, B.E, Tran, E.T, Chamberlain, P.P. | 登録日 | 2019-10-09 | 公開日 | 2020-04-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.58 Å) | 主引用文献 | Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex. Nat.Struct.Mol.Biol., 27, 2020
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3WX2
| Mouse Cereblon thalidomide binding domain, native | 分子名称: | Protein cereblon, SULFATE ION, ZINC ION | 著者 | Mori, T, Ito, T, Hirano, Y, Yamaguchi, Y, Handa, H, Hakoshima, T. | 登録日 | 2014-07-10 | 公開日 | 2014-08-06 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs Nat.Struct.Mol.Biol., 21, 2014
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3WX1
| Mouse Cereblon thalidomide binding domain, selenomethionine derivative | 分子名称: | Protein cereblon, SULFATE ION, ZINC ION | 著者 | Mori, T, Ito, T, Hirano, Y, Yamaguchi, Y, Handa, H, Hakoshima, T. | 登録日 | 2014-07-10 | 公開日 | 2014-08-06 | 最終更新日 | 2014-09-17 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs Nat.Struct.Mol.Biol., 21, 2014
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6N6O
| Crystal structure of the human TTK in complex with an inhibitor | 分子名称: | 1,2-ETHANEDIOL, 4-({5-chloro-4-[(cis-4-hydroxy-4-methylcyclohexyl)oxy]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)-N,N-dimethyl-3-{[(2R)-1,1,1-trifluoropropan-2-yl]oxy}benzamide, Dual specificity protein kinase TTK, ... | 著者 | Fenalti, G. | 登録日 | 2018-11-26 | 公開日 | 2019-05-15 | 最終更新日 | 2019-05-22 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy. J.Med.Chem., 62, 2019
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6B4W
| TTK in Complex with Inhibitor | 分子名称: | 4-{[4-(cyclopentyloxy)-5-(2-methyl-1,3-benzoxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-3-methoxy-N-methylbenzamide, CACODYLATE ION, Dual specificity protein kinase TTK | 著者 | Delker, S, Chamberlain, P.P. | 登録日 | 2017-09-27 | 公開日 | 2017-10-25 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen. J. Med. Chem., 60, 2017
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7MYZ
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1O63
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1O6C
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1O66
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1O60
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1O67
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1O62
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1O64
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1O65
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1O61
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