6Z3M
 
 | | Repulsive Guidance Molecule B (RGMB) in complex with Growth Differentiation Factor 5 (GDF5) and Neogenin 1 (NEO1). | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Growth/differentiation factor 5, Neogenin, ... | | 著者 | Malinauskas, T, Peer, T.V, Bishop, B, Muller, T.D, Siebold, C. | | 登録日 | 2020-05-21 | | 公開日 | 2020-07-01 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (5.501 Å) | | 主引用文献 | Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex.
Proc.Natl.Acad.Sci.USA, 117, 2020
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2YGO
 | | WIF domain-EGF-like domain 1 of human Wnt inhibitory factor 1 in complex with 1,2-dipalmitoylphosphatidylcholine | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, ... | | 著者 | Malinauskas, T, Aricescu, A.R, Lu, W, Siebold, C, Jones, E.Y. | | 登録日 | 2011-04-19 | | 公開日 | 2011-07-13 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Modular Mechanism of Wnt Signaling Inhibition by Wnt Inhibitory Factor 1
Nat.Struct.Mol.Biol., 18, 2011
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2YGN
 | | WIF domain of human Wnt inhibitory factor 1 in complex with 1,2- dipalmitoylphosphatidylcholine | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | | 著者 | Malinauskas, T, Aricescu, A.R, Lu, W, Siebold, C, Jones, E.Y. | | 登録日 | 2011-04-19 | | 公開日 | 2011-07-20 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Modular Mechanism of Wnt Signaling Inhibition by Wnt Inhibitory Factor 1
Nat.Struct.Mol.Biol., 18, 2011
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2YGQ
 | | WIF domain-epidermal growth factor (EGF)-like domains 1-3 of human Wnt inhibitory factor 1 in complex with 1,2- dipalmitoylphosphatidylcholine | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Malinauskas, T, Aricescu, A.R, Lu, W, Siebold, C, Jones, E.Y. | | 登録日 | 2011-04-19 | | 公開日 | 2011-07-13 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.951 Å) | | 主引用文献 | Modular Mechanism of Wnt Signaling Inhibition by Wnt Inhibitory Factor 1
Nat.Struct.Mol.Biol., 18, 2011
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2YGP
 | | WIF domain-EGF-like domain 1 Met77Trp of human Wnt inhibitory factor 1 in complex with 1,2-dipalmitoylphosphatidylcholine | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Malinauskas, T, Aricescu, A.R, Lu, W, Siebold, C, Jones, E.Y. | | 登録日 | 2011-04-19 | | 公開日 | 2011-07-13 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.222 Å) | | 主引用文献 | Modular Mechanism of Wnt Signaling Inhibition by Wnt Inhibitory Factor 1
Nat.Struct.Mol.Biol., 18, 2011
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6Z3J
 | | Repulsive Guidance Molecule B (RGMB) in complex with Growth Differentiation Factor 5 (GDF5) (crystal form 1) | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | 著者 | Malinauskas, T, Peer, T.V, Bishop, B, Muller, T.D, Siebold, C. | | 登録日 | 2020-05-20 | | 公開日 | 2020-07-01 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6Z3H
 | | Repulsive Guidance Molecule B (RGMB) in complex with Growth Differentiation Factor 5 (GDF5) (crystal form 2) | | 分子名称: | Growth/differentiation factor 5, RGM domain family member B | | 著者 | Malinauskas, T, Peer, T.V, Bishop, B, Muller, T.D, Siebold, C. | | 登録日 | 2020-05-20 | | 公開日 | 2020-07-01 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (3.158 Å) | | 主引用文献 | Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6Z3G
 | | Repulsive Guidance Molecule A (RGMA) in complex with Growth Differentiation Factor 5 (GDF5) | | 分子名称: | CITRIC ACID, Growth/differentiation factor 5, Repulsive guidance molecule A | | 著者 | Malinauskas, T, Peer, T.V, Bishop, B, Muller, T.D, Siebold, C. | | 登録日 | 2020-05-20 | | 公開日 | 2020-07-01 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | | 主引用文献 | Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6Z3L
 | | Repulsive Guidance Molecule C (RGMC, Hemojuvelin, HJV, HFE2) in complex with Growth Differentiation Factor 5 (GDF5) | | 分子名称: | Growth/differentiation factor 5, Hemojuvelin | | 著者 | Malinauskas, T, Peer, T.V, Bishop, B, Muller, T.D, Siebold, C. | | 登録日 | 2020-05-20 | | 公開日 | 2020-07-01 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.513 Å) | | 主引用文献 | Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex.
Proc.Natl.Acad.Sci.USA, 117, 2020
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8BWA
 | | Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1) in complex with platinum | | 分子名称: | PLATINUM (II) ION, Twisted gastrulation protein homolog 1 | | 著者 | Malinauskas, T, Rudolf, A.F, Moore, G, Eggington, H, Belnoue-Davis, H, El Omari, K, Woolley, R.E, Griffiths, S.C, Duman, R, Wagner, A, Leedham, S.J, Baldock, C, Ashe, H, Siebold, C. | | 登録日 | 2022-12-06 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (3.61 Å) | | 主引用文献 | Molecular mechanism of BMP signal control by Twisted gastrulation.
Nat Commun, 15, 2024
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8BWD
 | | Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1), crystal form 1 | | 分子名称: | SULFATE ION, Twisted gastrulation protein homolog 1 | | 著者 | Malinauskas, T, Rudolf, A.F, Moore, G, Eggington, H, Belnoue-Davis, H, El Omari, K, Woolley, R.E, Griffiths, S.C, Duman, R, Wagner, A, Leedham, S.J, Baldock, C, Ashe, H, Siebold, C. | | 登録日 | 2022-12-06 | | 公開日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | | 主引用文献 | Molecular mechanism of BMP signal control by Twisted gastrulation.
Nat Commun, 15, 2024
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8BWI
 | | Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1), crystal form 2 | | 分子名称: | Twisted gastrulation protein homolog 1 | | 著者 | Malinauskas, T, Rudolf, A.F, Moore, G, Eggington, H, Belnoue-Davis, H, El Omari, K, Woolley, R.E, Griffiths, S.C, Duman, R, Wagner, A, Leedham, S.J, Baldock, C, Ashe, H, Siebold, C. | | 登録日 | 2022-12-06 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Molecular mechanism of BMP signal control by Twisted gastrulation.
Nat Commun, 15, 2024
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8BWL
 | | Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1) in complex with human Growth Differentiation factor 5 (GDF5) and calcium | | 分子名称: | CALCIUM ION, Growth/differentiation factor 5, Twisted gastrulation protein homolog 1 | | 著者 | Malinauskas, T, Rudolf, A.F, Moore, G, Eggington, H, Belnoue-Davis, H, El Omari, K, Woolley, R.E, Griffiths, S.C, Duman, R, Wagner, A, Leedham, S.J, Baldock, C, Ashe, H, Siebold, C. | | 登録日 | 2022-12-06 | | 公開日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Molecular mechanism of BMP signal control by Twisted gastrulation.
Nat Commun, 15, 2024
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8BWN
 | | Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1) in complex with human Growth Differentiation Factor 5 (GDF5) and calcium, long-wavelength X-ray dataset (4010 eV) | | 分子名称: | CALCIUM ION, Growth/differentiation factor 5, Twisted gastrulation protein homolog 1 | | 著者 | Malinauskas, T, Rudolf, A.F, Moore, G, Eggington, H, Belnoue-Davis, H, El Omari, K, Woolley, R.E, Griffiths, S.C, Duman, R, Wagner, A, Leedham, S.J, Baldock, C, Ashe, H, Siebold, C. | | 登録日 | 2022-12-07 | | 公開日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | Molecular mechanism of BMP signal control by Twisted gastrulation.
Nat Commun, 15, 2024
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8BWM
 | | Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1) in complex with human Growth Differentiation factor 5 (GDF5) and calcium, long-wavelength X-ray dataset (4042 eV) | | 分子名称: | CALCIUM ION, Growth/differentiation factor 5, Twisted gastrulation protein homolog 1 | | 著者 | Malinauskas, T, Rudolf, A.F, Moore, G, Eggington, H, Belnoue-Davis, H, El Omari, K, Woolley, R.E, Griffiths, S.C, Duman, R, Wagner, A, Leedham, S.J, Baldock, C, Ashe, H, Siebold, C. | | 登録日 | 2022-12-07 | | 公開日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Molecular mechanism of BMP signal control by Twisted gastrulation.
Nat Commun, 15, 2024
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7NDG
 | | Cryo-EM structure of the ternary complex between Netrin-1, Neogenin and Repulsive Guidance Molecule B | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neogenin, ... | | 著者 | Robinson, R.A, Griffiths, S.C, van de Haar, L.L, Malinauskas, T, van Battum, E.Y, Zelina, P, Schwab, R.A, Karia, D, Malinauskaite, L, Brignani, S, van den Munkhof, M, Dudukcu, O, De Ruiter, A.A, Van den Heuvel, D.M.A, Bishop, B, Elegheert, J, Aricescu, A.R, Pasterkamp, R.J, Siebold, C. | | 登録日 | 2021-02-01 | | 公開日 | 2021-03-31 | | 最終更新日 | 2021-04-28 | | 実験手法 | ELECTRON MICROSCOPY (5.98 Å) | | 主引用文献 | Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.
Cell, 184, 2021
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8Q7O
 | | Crystal structure of the FZD3 cysteine-rich domain in complex with a nanobody (14478) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, DIMETHYL SULFOXIDE, ... | | 著者 | Hillier, J.S, Zhao, Y, Malinauskas, T, Jones, E.Y. | | 登録日 | 2023-08-16 | | 公開日 | 2024-08-28 | | 最終更新日 | 2024-09-04 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Structural insights into Frizzled3 through nanobody modulators.
Nat Commun, 15, 2024
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6HUK
 | | CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with bicuculline and megabody Mb38. | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit beta-3, ... | | 著者 | Masiulis, S, Desai, R, Uchanski, T, Serna Martin, I, Laverty, D, Karia, D, Malinauskas, T, Jasenko, Z, Pardon, E, Kotecha, A, Steyaert, J, Miller, K.W, Aricescu, A.R. | | 登録日 | 2018-10-08 | | 公開日 | 2019-01-02 | | 最終更新日 | 2022-03-30 | | 実験手法 | ELECTRON MICROSCOPY (3.69 Å) | | 主引用文献 | GABAAreceptor signalling mechanisms revealed by structural pharmacology.
Nature, 565, 2019
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7A4M
 | | Cryo-EM structure of mouse heavy-chain apoferritin at 1.22 A | | 分子名称: | FE (III) ION, Ferritin heavy chain, ZINC ION | | 著者 | Nakane, T, Kotecha, A, Sente, A, Yamashita, K, McMullan, G, Masiulis, S, Brown, P.M.G.E, Grigoras, I.T, Malinauskaite, L, Malinauskas, T, Miehling, J, Yu, L, Karia, D, Pechnikova, E.V, de Jong, E, Keizer, J, Bischoff, M, McCormack, J, Tiemeijer, P, Hardwick, S.W, Chirgadze, D.Y, Murshudov, G, Aricescu, A.R, Scheres, S.H.W. | | 登録日 | 2020-08-20 | | 公開日 | 2020-10-28 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (1.22 Å) | | 主引用文献 | Single-particle cryo-EM at atomic resolution.
Nature, 587, 2020
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7A5V
 | | CryoEM structure of a human gamma-aminobutyric acid receptor, the GABA(A)R-beta3 homopentamer, in complex with histamine and megabody Mb25 in lipid nanodisc | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | 著者 | Nakane, T, Kotecha, A, Sente, A, Yamashita, K, McMullan, G, Masiulis, S, Brown, P.M.G.E, Grigoras, I.T, Malinauskaite, L, Malinauskas, T, Miehling, J, Yu, L, Karia, D, Pechnikova, E.V, de Jong, E, Keizer, J, Bischoff, M, McCormack, J, Tiemeijer, P, Hardwick, S.W, Chirgadze, D.Y, Murshudov, G, Aricescu, A.R, Scheres, S.H.W. | | 登録日 | 2020-08-22 | | 公開日 | 2020-11-18 | | 最終更新日 | 2020-11-25 | | 実験手法 | ELECTRON MICROSCOPY (1.7 Å) | | 主引用文献 | Single-particle cryo-EM at atomic resolution.
Nature, 587, 2020
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7NE1
 | | Structure of the complex between Netrin-1 and its receptor Neogenin | | 分子名称: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Robinson, R.A, Griffiths, S.C, van de Haar, L.L, Malinauskas, T, van Battum, E.Y, Zelina, P, Schwab, R.A, Karia, D, Malinauskaite, L, Brignani, S, van den Munkhof, M, Dudukcu, O, De Ruiter, A.A, Van den Heuvel, D.M.A, Bishop, B, Elegheert, J, Aricescu, A.R, Pasterkamp, R.J, Siebold, C. | | 登録日 | 2021-02-02 | | 公開日 | 2021-03-31 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.
Cell, 184, 2021
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7NE0
 | | Structure of the ternary complex between Netrin-1, Repulsive-Guidance Molecule-B (RGMB) and Neogenin | | 分子名称: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Robinson, R.A, Griffiths, S.C, van de Haar, L.L, Malinauskas, T, van Battum, E.Y, Zelina, P, Schwab, R.A, Karia, D, Malinauskaite, L, Brignani, S, van den Munkhof, M, Dudukcu, O, De Ruiter, A.A, Van den Heuvel, D.M.A, Bishop, B, Elegheert, J, Aricescu, A.R, Pasterkamp, R.J, Siebold, C. | | 登録日 | 2021-02-02 | | 公開日 | 2021-03-31 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | | 主引用文献 | Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.
Cell, 184, 2021
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4GZA
 | | Complex of mouse Plexin A2 - Semaphorin 3A - Neuropilin-1 | | 分子名称: | CALCIUM ION, Neuropilin-1, Plexin-A2, ... | | 著者 | Janssen, B.J.C, Malinauskas, T, Siebold, C, Jones, E.Y. | | 登録日 | 2012-09-06 | | 公開日 | 2012-10-17 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (7 Å) | | 主引用文献 | Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.
Nat.Struct.Mol.Biol., 19, 2012
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4GZ8
 | | Mouse Semaphorin 3A, domains Sema-PSI-IG | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | | 著者 | Janssen, B.J.C, Malinauskas, T, Siebold, C, Jones, E.Y. | | 登録日 | 2012-09-06 | | 公開日 | 2012-10-17 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.
Nat.Struct.Mol.Biol., 19, 2012
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4GZ9
 | | Mouse Neuropilin-1, extracellular domains 1-4 (a1a2b1b2) | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Janssen, B.J.C, Malinauskas, T, Siebold, C, Jones, E.Y. | | 登録日 | 2012-09-06 | | 公開日 | 2012-10-17 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.
Nat.Struct.Mol.Biol., 19, 2012
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