6Z3L
Repulsive Guidance Molecule C (RGMC, Hemojuvelin, HJV, HFE2) in complex with Growth Differentiation Factor 5 (GDF5)
Summary for 6Z3L
Entry DOI | 10.2210/pdb6z3l/pdb |
Related | 6Z3G 6Z3H 6Z3J |
Descriptor | Growth/differentiation factor 5, Hemojuvelin (3 entities in total) |
Functional Keywords | repulsive guidance molecule, rgm, bone morphogenetic protein, bmp, growth differentiation factor 5, gdf5, neogenin, axon guidance, tgfbeta signalling, brain development, iron metabolism, hemojuvelin, hjv, hfe2, hemochromatosis type 2 protein, juvenile hemochromatosis., signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 25807.47 |
Authors | Malinauskas, T.,Peer, T.V.,Bishop, B.,Muller, T.D.,Siebold, C. (deposition date: 2020-05-20, release date: 2020-07-01, Last modification date: 2024-01-24) |
Primary citation | Malinauskas, T.,Peer, T.V.,Bishop, B.,Mueller, T.D.,Siebold, C. Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex. Proc.Natl.Acad.Sci.USA, 117:15620-15631, 2020 Cited by PubMed: 32576689DOI: 10.1073/pnas.2000561117 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.513 Å) |
Structure validation
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