6Z3L

Repulsive Guidance Molecule C (RGMC, Hemojuvelin, HJV, HFE2) in complex with Growth Differentiation Factor 5 (GDF5)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Growth/differentiation factor 5	polymer	117	13405.5	1	UniProt (P43026) Pfam (PF00019)	Homo sapiens (Human)	GDF-5,Bone morphogenetic protein 14,BMP-14,Cartilage-derived morphogenetic protein 1,CDMP-1,Lipopolysaccharide-associated protein 4,LPS-associated protein 4,Radotermin
2	B (B)	Hemojuvelin	polymer	122	12402.0	1	UniProt (Q6ZVN8) Pfam (PF06535)	Homo sapiens (Human)	Hemochromatosis type 2 protein,Hemojuvelin BMP coreceptor,RGM domain family member C
3	C (A)	water	water		18.0	12	Chemie (HOH)

Sequence modifications

A: 387 - 501 (UniProt: P43026)

PDB	External Database	Details
Met 385	-	initiating methionine
Lys 386	-	expression tag

B: 36 - 145 (UniProt: Q6ZVN8)

PDB	External Database	Details
Glu 33	-	expression tag
Thr 34	-	expression tag
Gly 35	-	expression tag
Gly 146	-	expression tag
Thr 147	-	expression tag
Lys 148	-	expression tag
His 149	-	expression tag
His 150	-	expression tag
His 151	-	expression tag
His 152	-	expression tag
His 153	-	expression tag
His 154	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	25807.5
All*	Total formula weight	25807.5

*Water molecules are not included.