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8A8X
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BU of 8a8x by Molmil
TRIM7 PRYSPRY in complex with a MNV1-NS3 peptide HDDFGLQ
分子名称: E3 ubiquitin-protein ligase TRIM7, MNV1-NS3 C term peptide
著者Luptak, J.
登録日2022-06-24
公開日2022-07-06
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献TRIM7 Restricts Coxsackievirus and Norovirus Infection by Detecting the C-Terminal Glutamine Generated by 3C Protease Processing.
Viruses, 14, 2022
8A5L
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BU of 8a5l by Molmil
TRIM7 PRYSPRY in complex with a 2BC peptide TIEALFQ
分子名称: 2BC peptide TIEALFQ, D(-)-TARTARIC ACID, E3 ubiquitin-protein ligase TRIM7
著者Luptak, J.
登録日2022-06-15
公開日2022-07-06
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.622 Å)
主引用文献TRIM7 Restricts Coxsackievirus and Norovirus Infection by Detecting the C-Terminal Glutamine Generated by 3C Protease Processing.
Viruses, 14, 2022
8A5M
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BU of 8a5m by Molmil
TRIM7 PRYSPRY in complex with a MNV1-NS6 peptide LEALEFQ
分子名称: E3 ubiquitin-protein ligase TRIM7, MNV1-NS6 peptide LEALEFQ, PHOSPHATE ION
著者Luptak, J.
登録日2022-06-15
公開日2022-07-06
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.918 Å)
主引用文献TRIM7 Restricts Coxsackievirus and Norovirus Infection by Detecting the C-Terminal Glutamine Generated by 3C Protease Processing.
Viruses, 14, 2022
6QBC
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BU of 6qbc by Molmil
structure of anti-Mcl1 Fab
分子名称: Anti-Mcl1 Fab Heavy Chain, Anti-Mcl1 Fab Light Chain
著者Luptak, J.
登録日2018-12-20
公開日2019-11-06
最終更新日2019-11-13
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1.
Acta Crystallogr D Struct Biol, 75, 2019
6QF6
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BU of 6qf6 by Molmil
Structure of an E.coli expressed anti-Mcl1 scFv
分子名称: E.coli expressed scFv
著者Luptak, J.
登録日2019-01-09
公開日2019-11-13
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Structure of an E.coli expressed anti-Mcl1 scFv
To Be Published
6QF9
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BU of 6qf9 by Molmil
Structure of an anti-Mcl1 scFv
分子名称: scFv
著者Luptak, J.
登録日2019-01-09
公開日2019-11-06
最終更新日2019-11-13
実験手法X-RAY DIFFRACTION (1.43 Å)
主引用文献Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1.
Acta Crystallogr D Struct Biol, 75, 2019
6QFC
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BU of 6qfc by Molmil
Structure of an anti-Mcl1 scFv
分子名称: DIMETHYL SULFOXIDE, Induced myeloid leukemia cell differentiation protein Mcl-1, scFv55
著者Luptak, J.
登録日2019-01-09
公開日2019-11-06
最終更新日2019-11-13
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1.
Acta Crystallogr D Struct Biol, 75, 2019
6QB6
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BU of 6qb6 by Molmil
Mcl1 in complex with a Fab
分子名称: Fab Heavy Chain, Fab Light Chain, Induced myeloid leukemia cell differentiation protein Mcl-1
著者Hargreaves, D.
登録日2018-12-20
公開日2019-11-06
最終更新日2019-11-13
実験手法X-RAY DIFFRACTION (2.24 Å)
主引用文献Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1.
Acta Crystallogr D Struct Biol, 75, 2019
6QB3
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BU of 6qb3 by Molmil
Apo Mcl1 in a complex with a scFv
分子名称: Induced myeloid leukemia cell differentiation protein Mcl-1, scFv55
著者Kazmirski, S, Hargreaves, D.
登録日2018-12-20
公開日2019-11-06
最終更新日2019-11-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1.
Acta Crystallogr D Struct Biol, 75, 2019
6QB4
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BU of 6qb4 by Molmil
Mcl1-scFv complex with an indole acid inhibitor
分子名称: 3-[3-[[(1~{R})-1,2,3,4-tetrahydronaphthalen-1-yl]oxy]propyl]-7-(1,3,5-trimethylpyrazol-4-yl)-1~{H}-indole-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1, scFv55
著者Hargreaves, D.
登録日2018-12-20
公開日2019-11-06
最終更新日2019-11-13
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1.
Acta Crystallogr D Struct Biol, 75, 2019
6QB9
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BU of 6qb9 by Molmil
Structure of an anti-Mcl1 scFv
分子名称: L(+)-TARTARIC ACID, scFv55
著者Hargreaves, D.
登録日2018-12-20
公開日2019-11-06
最終更新日2019-11-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1.
Acta Crystallogr D Struct Biol, 75, 2019
9F9A
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BU of 9f9a by Molmil
Crystal structure of MUS81-EME1 bound by compound 12.
分子名称: 2-naphthalen-2-yl-5-oxidanyl-6-oxidanylidene-1H-pyrimidine-4-carboxylic acid, Crossover junction endonuclease EME1, Crossover junction endonuclease MUS81, ...
著者Collie, G.W.
登録日2024-05-07
公開日2024-06-19
最終更新日2024-07-31
実験手法X-RAY DIFFRACTION (2.911 Å)
主引用文献Fragment-Based Discovery of Novel MUS81 Inhibitors.
Acs Med.Chem.Lett., 15, 2024
9F9K
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BU of 9f9k by Molmil
Crystal structure of MUS81-EME1 bound by compound 15.
分子名称: 5-oxidanyl-6-oxidanylidene-2-(4-phenylphenyl)-1H-pyrimidine-4-carboxylic acid, Crossover junction endonuclease EME1, Crossover junction endonuclease MUS81, ...
著者Collie, G.W.
登録日2024-05-07
公開日2024-07-03
最終更新日2024-07-31
実験手法X-RAY DIFFRACTION (2.728 Å)
主引用文献Fragment-Based Discovery of Novel MUS81 Inhibitors.
Acs Med.Chem.Lett., 15, 2024
9F9L
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BU of 9f9l by Molmil
Crystal structure of MUS81-EME1 bound by compound 16.
分子名称: 2-[2-[4-(cyanomethyl)phenyl]phenyl]-5-oxidanyl-6-oxidanylidene-1H-pyrimidine-4-carboxylic acid, Crossover junction endonuclease EME1, Crossover junction endonuclease MUS81, ...
著者Collie, G.W.
登録日2024-05-07
公開日2024-07-03
最終更新日2024-07-31
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Fragment-Based Discovery of Novel MUS81 Inhibitors.
Acs Med.Chem.Lett., 15, 2024
9F98
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BU of 9f98 by Molmil
Crystal structure of MUS81-EME1, apo form.
分子名称: Crossover junction endonuclease EME1, Crossover junction endonuclease MUS81
著者Collie, G.W.
登録日2024-05-07
公開日2024-07-03
最終更新日2024-07-31
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Fragment-Based Discovery of Novel MUS81 Inhibitors.
Acs Med.Chem.Lett., 15, 2024
9F99
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BU of 9f99 by Molmil
Crystal structure of MUS81-EME1 bound by compound 10.
分子名称: 2-(4-chlorophenyl)-5-oxidanyl-6-oxidanylidene-1H-pyrimidine-4-carboxylic acid, Crossover junction endonuclease EME1, Crossover junction endonuclease MUS81, ...
著者Collie, G.W.
登録日2024-05-07
公開日2024-06-19
最終更新日2024-07-31
実験手法X-RAY DIFFRACTION (2.803 Å)
主引用文献Fragment-Based Discovery of Novel MUS81 Inhibitors.
Acs Med.Chem.Lett., 15, 2024
9F9M
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BU of 9f9m by Molmil
Crystal structure of MUS81-EME1 bound by compound 21.
分子名称: 5-oxidanyl-4-oxidanylidene-1-(4-piperazin-1-ylphenyl)pyridine-3-carboxylic acid, Crossover junction endonuclease EME1, Crossover junction endonuclease MUS81, ...
著者Collie, G.W.
登録日2024-05-08
公開日2024-06-19
最終更新日2024-07-31
実験手法X-RAY DIFFRACTION (2.469 Å)
主引用文献Fragment-Based Discovery of Novel MUS81 Inhibitors.
Acs Med.Chem.Lett., 15, 2024
8A58
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BU of 8a58 by Molmil
X-ray structure of TRIM21 RING E3 ligase in complex with E2 enzyme Ube2W
分子名称: E3 ubiquitin-protein ligase TRIM21, Ubiquitin-conjugating enzyme E2 W, ZINC ION
著者James, L.C, Kiss, L.
登録日2022-06-14
公開日2023-04-26
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates.
Nat Commun, 14, 2023

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件を2024-07-31に公開中

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