6QB4

Mcl1-scFv complex with an indole acid inhibitor

Summary for 6QB4

• Entry DOI: 10.2210/pdb6qb4/pdb
• Related: 6QB3
• Descriptor: Induced myeloid leukemia cell differentiation protein Mcl-1, scFv55, 3-[3-[[(1~{R})-1,2,3,4-tetrahydronaphthalen-1-yl]oxy]propyl]-7-(1,3,5-trimethylpyrazol-4-yl)-1~{H}-indole-2-carboxylic acid, ... (4 entities in total)
• Functional Keywords: mcl1, scfv, indole acid, apoptosis
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 45114.11

Authors

Hargreaves, D. (deposition date: 2018-12-20, release date: 2019-11-06, Last modification date: 2019-11-13)

• Primary citation: Luptak, J.,Bista, M.,Fisher, D.,Flavell, L.,Gao, N.,Wickson, K.,Kazmirski, S.L.,Howard, T.,Rawlins, P.B.,Hargreaves, D.; Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1.; Acta Crystallogr D Struct Biol, 75:1003-1014, 2019; PubMed: 31692474; DOI: 10.1107/S2059798319014116

Experimental method

X-RAY DIFFRACTION (2.38 Å)