6QB4

Mcl1-scFv complex with an indole acid inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Induced myeloid leukemia cell differentiation protein Mcl-1	polymer	162	18227.6	1	UniProt (Q07820) Pfam (PF00452) In PDB	Homo sapiens (Human)	Bcl-2-like protein 3,Bcl2-L-3,Bcl-2-related protein EAT/mcl1,mcl1/EAT
2	X	scFv55	polymer	255	26429.0	1		Homo sapiens
3	A	3-[3-[[(1~{R})-1,2,3,4-tetrahydronaphthalen-1-yl]oxy]propyl]-7-(1,3,5-trimethylpyrazol-4-yl)-1~{H}-indole-2-carboxylic acid	non-polymer		457.6	1	Chemie (HVN)
4		water	water		18.0	157	Chemie (HOH)

Sequence modifications

A: 174 - 327 (UniProt: Q07820)

PDB	External Database	Details
Gly 166	-	expression tag
Pro 167	-	expression tag
Leu 168	-	expression tag
Gly 169	-	expression tag
Ser 170	-	expression tag
Glu 171	-	expression tag
Asp 172	-	expression tag
Asp 173	-	expression tag
Ser 193	Ala 193	conflict
Ser 196	Thr 196	conflict
Leu 199	Met 199	conflict
Glu 201	Arg 201	conflict
Ala 202	Ser 202	conflict
Ala 205	Thr 205	conflict
Gly 206	Ser 206	conflict
Arg 208	Lys 208	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	44656.6
Non-Polymers*	Number of molecules	1
	Total formula weight	457.6
All*	Total formula weight	45114.1

*Water molecules are not included.