5Y3E
 
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5Y3Q
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7CZ4
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7C33
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7C4H
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7COT
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5YB9
 | | Crystal structure of a dimeric cyclophilin A from T.vaginalis | | 分子名称: | Peptidyl-prolyl cis-trans isomerase | | 著者 | Cho, C.C, Lin, M.H, Chou, C.C, Martin, T, Chen, C, Hsu, C.H. | | 登録日 | 2017-09-04 | | 公開日 | 2018-07-18 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.276 Å) | | 主引用文献 | Structural basis of interaction between dimeric cyclophilin 1 and Myb1 transcription factor in Trichomonas vaginalis
Sci Rep, 8, 2018
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5YBA
 | | Dimeric Cyclophilin from T.vaginalis in complex with Myb1 peptide | | 分子名称: | Myb1 peptide, Peptidyl-prolyl cis-trans isomerase | | 著者 | Cho, C.C, Lin, M.H, Martin, T, Chou, C.C, Chen, C, Hsu, C.H. | | 登録日 | 2017-09-04 | | 公開日 | 2018-07-18 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.062 Å) | | 主引用文献 | Structural basis of interaction between dimeric cyclophilin 1 and Myb1 transcription factor in Trichomonas vaginalis
Sci Rep, 8, 2018
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8I26
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8I25
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8UIB
 | | Structure of the human INTS9-INTS11-BRAT1 complex | | 分子名称: | BRCA1-associated ATM activator 1, Integrator complex subunit 11, Integrator complex subunit 9, ... | | 著者 | Lin, M, Tong, L. | | 登録日 | 2023-10-10 | | 公開日 | 2024-08-21 | | 最終更新日 | 2025-06-04 | | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | | 主引用文献 | Cytoplasmic binding partners of the Integrator endonuclease INTS11 and its paralog CPSF73 are required for their nuclear function.
Mol.Cell, 84, 2024
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8UIC
 | | Structure of the Drosophila IntS11-CG7044(dBRAT1) complex | | 分子名称: | FI02071p, Integrator complex subunit 11, ZINC ION | | 著者 | Lin, M, Tong, L. | | 登録日 | 2023-10-10 | | 公開日 | 2024-08-21 | | 最終更新日 | 2025-05-14 | | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | | 主引用文献 | Cytoplasmic binding partners of the Integrator endonuclease INTS11 and its paralog CPSF73 are required for their nuclear function.
Mol.Cell, 84, 2024
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7SN8
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4UMK
 | | The complex of Spo0J and parS DNA in chromosomal partition system | | 分子名称: | DNA, PROBABLE CHROMOSOME-PARTITIONING PROTEIN PARB, SULFATE ION | | 著者 | Chen, B.W, Chu, C.H, Tung, J.Y, Hsu, C.E, Hsiao, C.D, Sun, Y.J. | | 登録日 | 2014-05-19 | | 公開日 | 2015-05-13 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (3.096 Å) | | 主引用文献 | Insights into ParB spreading from the complex structure of Spo0J and parS.
Proc. Natl. Acad. Sci. U.S.A., 112, 2015
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8G1U
 | | Structure of the methylosome-Lsm10/11 complex | | 分子名称: | ADENOSINE, Methylosome protein 50, Methylosome subunit pICln, ... | | 著者 | Lin, M, Paige, A, Tong, L. | | 登録日 | 2023-02-03 | | 公開日 | 2023-08-23 | | 最終更新日 | 2025-05-28 | | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | | 主引用文献 | In vitro methylation of the U7 snRNP subunits Lsm11 and SmE by the PRMT5/MEP50/pICln methylosome.
Rna, 29, 2023
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4XMO
 | | Crystal structure of c-Met in complex with (R)-5-(8-fluoro-3-(1-fluoro-1-(3-methoxyquinolin-6-yl)ethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-3-methylisoxazole | | 分子名称: | 6-{(1R)-1-fluoro-1-[8-fluoro-6-(3-methyl-1,2-oxazol-5-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl}-3-methoxyquinoline, Hepatocyte growth factor receptor | | 著者 | Whittington, D.A, Long, A.M. | | 登録日 | 2015-01-14 | | 公開日 | 2015-03-11 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Discovery of Potent and Selective 8-Fluorotriazolopyridine c-Met Inhibitors.
J.Med.Chem., 58, 2015
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4XYF
 | | Crystal structure of c-Met in complex with (S)-5-(8-fluoro-3-(1-(3-(2-methoxyethoxy)quinolin-6-yl)ethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-3-methylisoxazole | | 分子名称: | 6-{(1S)-1-[8-fluoro-6-(3-methyl-1,2-oxazol-5-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl}-3-(2-methoxyethoxy)quinoline, Hepatocyte growth factor receptor | | 著者 | Whittington, D.A, Long, A.M. | | 登録日 | 2015-02-02 | | 公開日 | 2015-03-11 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Discovery of Potent and Selective 8-Fluorotriazolopyridine c-Met Inhibitors.
J.Med.Chem., 58, 2015
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3I5N
 | | Crystal structure of c-Met with triazolopyridazine inhibitor 13 | | 分子名称: | 7-methoxy-N-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl]-1,5-naphthyridin-4-amine, Hepatocyte growth factor receptor | | 著者 | Bellon, S.F, Whittington, D.A, Long, A.M, Boezio, A.A. | | 登録日 | 2009-07-06 | | 公開日 | 2010-01-12 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors
Bioorg.Med.Chem.Lett., 19, 2009
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5KS8
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5B7C
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5EYC
 | | Crystal structure of c-Met in complex with naphthyridinone inhibitor 5 | | 分子名称: | 6-[(1~{R})-1-[8-fluoranyl-6-(3-methyl-1,2-oxazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl]-1,6-naphthyridin-5-one, Hepatocyte growth factor receptor | | 著者 | Whittington, D.A, Long, A.M. | | 登録日 | 2015-11-24 | | 公開日 | 2016-02-10 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Discovery of (R)-6-(1-(8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo Antitumor Activity.
J.Med.Chem., 59, 2016
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5EYD
 | | Crystal structure of c-Met in complex with AMG 337 | | 分子名称: | 6-[(1~{R})-1-[8-fluoranyl-6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl]-3-(2-methoxyethoxy)-1,6-naphthyridin-5-one, Hepatocyte growth factor receptor | | 著者 | Whittington, D.A, Long, A.M. | | 登録日 | 2015-11-24 | | 公開日 | 2016-02-10 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Discovery of (R)-6-(1-(8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo Antitumor Activity.
J.Med.Chem., 59, 2016
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7Y0G
 | | Crystal structure of anti-mPEG h15-2b Fab | | 分子名称: | 15-2b heavy chain, 15-2b light chain, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL | | 著者 | Chang, C.Y, Nguyen, T.M.T, Lin, E.C, Su, Y.C. | | 登録日 | 2022-06-05 | | 公開日 | 2022-08-10 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | | 主引用文献 | Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group.
Commun Chem, 5, 2022
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7YIZ
 | | Crystal structure of anti-mPEG h15-2b Fab W104Y mutant | | 分子名称: | 15-2b W104Y heavy chain, 15-2b light chain, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL | | 著者 | Chang, C.Y, Nguyen, T.M.T, Li, Y.C, Su, Y.C. | | 登録日 | 2022-07-18 | | 公開日 | 2023-08-02 | | 最終更新日 | 2025-02-12 | | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | | 主引用文献 | Engineering a High-Affinity Anti-Methoxy Poly(ethylene glycol) (mPEG) Antibody for Sensitive Immunosensing of mPEGylated Therapeutics and mPEG Molecules
Bioconjug.Chem., 33, 2022
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8Z95
 | | Humanized anti-PEG h6.3 Fab in complex with PEG | | 分子名称: | 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL, Heavy chain of Anti-PEG antibody h6-3 Fab fragment, ISOPROPYL ALCOHOL, ... | | 著者 | Lin, Y.C, Chang, C.Y, Su, Y.C. | | 登録日 | 2024-04-22 | | 公開日 | 2025-02-12 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | pH-Responsive Polyethylene Glycol Engagers for Enhanced Brain Delivery of PEGylated Nanomedicine to Treat Glioblastoma.
Acs Nano, 19, 2025
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