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3I5N

Crystal structure of c-Met with triazolopyridazine inhibitor 13

Summary for 3I5N
Entry DOI10.2210/pdb3i5n/pdb
Related3CD8
DescriptorHepatocyte growth factor receptor, 7-methoxy-N-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl]-1,5-naphthyridin-4-amine (3 entities in total)
Functional Keywordsproto-oncogene, rtk, receptor tyrosine kinase, scatter factor receptor, hgf/sf, alternative splicing, atp-binding, chromosomal rearrangement, disease mutation, disulfide bond, glycoprotein, kinase, membrane, nucleotide-binding, phosphoprotein, polymorphism, receptor, transferase, transmembrane, tyrosine-protein kinase
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein: P08581
Total number of polymer chains1
Total formula weight35599.12
Authors
Bellon, S.F.,Whittington, D.A.,Long, A.M.,Boezio, A.A. (deposition date: 2009-07-06, release date: 2010-01-12, Last modification date: 2023-09-06)
Primary citationBoezio, A.A.,Berry, L.,Albrecht, B.K.,Bauer, D.,Bellon, S.F.,Bode, C.,Chen, A.,Choquette, D.,Dussault, I.,Hirai, S.,Kaplan-Lefko, P.,Larrow, J.F.,Lin, M.H.,Lohman, J.,Potashman, M.H.,Rex, K.,Santostefano, M.,Shah, K.,Shimanovich, R.,Springer, S.K.,Teffera, Y.,Yang, Y.,Zhang, Y.,Harmange, J.C.
Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors
Bioorg.Med.Chem.Lett., 19:6307-6312, 2009
Cited by
PubMed: 19819693
DOI: 10.1016/j.bmcl.2009.09.096
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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