7YIZ

Crystal structure of anti-mPEG h15-2b Fab W104Y mutant

Summary for 7YIZ

Entry DOI	10.2210/pdb7yiz/pdb
Descriptor	15-2b light chain, 15-2b W104Y heavy chain, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, ... (4 entities in total)
Functional Keywords	methoxy polyethylene glycol, anti-mpeg antibody, immune system
Biological source	Homo sapiens More
Total number of polymer chains	4
Total formula weight	96821.69
Authors	Chang, C.Y.,Nguyen, T.M.T.,Li, Y.C.,Su, Y.C. (deposition date: 2022-07-18, release date: 2023-08-02, Last modification date: 2025-02-12)
Primary citation	Hsiao, C.Y.,Meng, J.L.,Hong, J.Z.,Ly, X.H.,Lin, M.H.,Chang, C.Y.,Nguyen, M.T.T.,Cheng, T.L.,Lin, W.W.,Burnouf, P.A.,Al-Qaisi, T.S.,Liu, E.S.,Su, Y.C. Engineering a High-Affinity Anti-Methoxy Poly(ethylene glycol) (mPEG) Antibody for Sensitive Immunosensing of mPEGylated Therapeutics and mPEG Molecules Bioconjug.Chem., 33:2180-2188, 2022 Cited by DOI: 10.1021/acs.bioconjchem.2c00416 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.42 Å)

Structure validation