4XYF
Crystal structure of c-Met in complex with (S)-5-(8-fluoro-3-(1-(3-(2-methoxyethoxy)quinolin-6-yl)ethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-3-methylisoxazole
Summary for 4XYF
Entry DOI | 10.2210/pdb4xyf/pdb |
Related | 4XMO |
Descriptor | Hepatocyte growth factor receptor, 6-{(1S)-1-[8-fluoro-6-(3-methyl-1,2-oxazol-5-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl}-3-(2-methoxyethoxy)quinoline (3 entities in total) |
Functional Keywords | receptor tyrosine kinase, inhibitor, complex, intracellular catalytic domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581 |
Total number of polymer chains | 1 |
Total formula weight | 35663.18 |
Authors | Whittington, D.A.,Long, A.M. (deposition date: 2015-02-02, release date: 2015-03-11, Last modification date: 2023-09-27) |
Primary citation | Peterson, E.A.,Teffera, Y.,Albrecht, B.K.,Bauer, D.,Bellon, S.F.,Boezio, A.,Boezio, C.,Broome, M.A.,Choquette, D.,Copeland, K.W.,Dussault, I.,Lewis, R.,Lin, M.H.,Lohman, J.,Liu, J.,Potashman, M.,Rex, K.,Shimanovich, R.,Whittington, D.A.,Vaida, K.R.,Harmange, J.C. Discovery of Potent and Selective 8-Fluorotriazolopyridine c-Met Inhibitors. J.Med.Chem., 58:2417-2430, 2015 Cited by PubMed: 25699405DOI: 10.1021/jm501913a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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