4XMO

Crystal structure of c-Met in complex with (R)-5-(8-fluoro-3-(1-fluoro-1-(3-methoxyquinolin-6-yl)ethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-3-methylisoxazole

Summary for 4XMO

Entry DOI	10.2210/pdb4xmo/pdb
Descriptor	Hepatocyte growth factor receptor, 6-{(1R)-1-fluoro-1-[8-fluoro-6-(3-methyl-1,2-oxazol-5-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl}-3-methoxyquinoline (3 entities in total)
Functional Keywords	receptor tyrosine kinase, intracellular catalytic domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
Total number of polymer chains	1
Total formula weight	35637.11
Authors	Whittington, D.A.,Long, A.M. (deposition date: 2015-01-14, release date: 2015-03-11, Last modification date: 2024-02-28)
Primary citation	Peterson, E.A.,Teffera, Y.,Albrecht, B.K.,Bauer, D.,Bellon, S.F.,Boezio, A.,Boezio, C.,Broome, M.A.,Choquette, D.,Copeland, K.W.,Dussault, I.,Lewis, R.,Lin, M.H.,Lohman, J.,Liu, J.,Potashman, M.,Rex, K.,Shimanovich, R.,Whittington, D.A.,Vaida, K.R.,Harmange, J.C. Discovery of Potent and Selective 8-Fluorotriazolopyridine c-Met Inhibitors. J.Med.Chem., 58:2417-2430, 2015 Cited by PubMed: 25699405 DOI: 10.1021/jm501913a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation