6URY
 
 | | Crystal structure of ricin A chain in complex with inhibitor 9-oxo-4-fluorenecarboxamide | | 分子名称: | 1,2-ETHANEDIOL, 9-oxo-9H-fluorene-4-carboxamide, CHLORIDE ION, ... | | 著者 | Harijan, R.K, Li, X.P, Bonanno, J.B, Almo, S.C, Tumer, N.E, Schramm, V.L. | | 登録日 | 2019-10-24 | | 公開日 | 2020-06-17 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Small Molecule Inhibitors Targeting the Interaction of Ricin Toxin A Subunit with Ribosomes.
Acs Infect Dis., 6, 2020
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6URX
 | | Crystal structure of ricin A chain in complex with inhibitor 5-phenyl-2-thiophenecarboxylic acid | | 分子名称: | 1,2-ETHANEDIOL, 5-phenylthiophene-2-carboxylic acid, DIMETHYL SULFOXIDE, ... | | 著者 | Harijan, R.K, Li, X.P, Bonanno, J.B, Almo, S.C, Tumer, N.E, Schramm, V.L. | | 登録日 | 2019-10-24 | | 公開日 | 2020-06-17 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Small Molecule Inhibitors Targeting the Interaction of Ricin Toxin A Subunit with Ribosomes.
Acs Infect Dis., 6, 2020
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6URW
 | | Crystal structure of ricin A chain in complex with inhibitor 4-(2-thienylmethyl)benzoic acid | | 分子名称: | 1,2-ETHANEDIOL, 4-[(thiophen-2-yl)methyl]benzoic acid, DIMETHYL SULFOXIDE, ... | | 著者 | Harijan, R.K, Li, X.P, Bonanno, J.B, Almo, S.C, Tumer, N.E, Schramm, V.L. | | 登録日 | 2019-10-24 | | 公開日 | 2020-06-17 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Small Molecule Inhibitors Targeting the Interaction of Ricin Toxin A Subunit with Ribosomes.
Acs Infect Dis., 6, 2020
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7MLP
 | | Crystal structure of ricin A chain in complex with 5-(2,6-dimethylphenyl)thiophene-2-carboxylic acid | | 分子名称: | 1,2-ETHANEDIOL, 5-(2,6-dimethylphenyl)thiophene-2-carboxylic acid, Ricin, ... | | 著者 | Harijan, R.K, Li, X.P, Cao, B, Augeri, D, Bonanno, J.B, Almo, S.C, Tumer, N.E, Schramm, V.L. | | 登録日 | 2021-04-28 | | 公開日 | 2022-02-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Synthesis and Structural Characterization of Ricin Inhibitors Targeting Ribosome Binding Using Fragment-Based Methods and Structure-Based Design.
J.Med.Chem., 64, 2021
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7MLN
 | | Crystal structure of ricin A chain in complex with 5-(o-tolyl)thiophene-2-carboxylic acid | | 分子名称: | 5-(2-methylphenyl)thiophene-2-carboxylic acid, GLYCEROL, Ricin | | 著者 | Harijan, R.K, Li, X.P, Cao, B, Augeri, D, Bonanno, J.B, Almo, S.C, Tumer, N.E, Schramm, V.L. | | 登録日 | 2021-04-28 | | 公開日 | 2022-02-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | | 主引用文献 | Synthesis and Structural Characterization of Ricin Inhibitors Targeting Ribosome Binding Using Fragment-Based Methods and Structure-Based Design.
J.Med.Chem., 64, 2021
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7MLO
 | | Crystal structure of ricin A chain in complex with 5-mesitylthiophene-2-carboxylic acid | | 分子名称: | 1,2-ETHANEDIOL, 5-(2,4,6-trimethylphenyl)thiophene-2-carboxylic acid, Ricin, ... | | 著者 | Harijan, R.K, Li, X.P, Cao, B, Augeri, D, Bonanno, J.B, Almo, S.C, Tumer, N.E, Schramm, V.L. | | 登録日 | 2021-04-28 | | 公開日 | 2022-02-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Synthesis and Structural Characterization of Ricin Inhibitors Targeting Ribosome Binding Using Fragment-Based Methods and Structure-Based Design.
J.Med.Chem., 64, 2021
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7MLT
 | | Crystal structure of ricin A chain in complex with 5-(2-ethylphenyl)thiophene-2-carboxylic acid | | 分子名称: | 1,2-ETHANEDIOL, 5-(2-ethylphenyl)thiophene-2-carboxylic acid, CHLORIDE ION, ... | | 著者 | Harijan, R.K, Li, X.P, Cao, B, Augeri, D, Bonanno, J.B, Almo, S.C, Tumer, N.E, Schramm, V.L. | | 登録日 | 2021-04-29 | | 公開日 | 2022-02-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Synthesis and Structural Characterization of Ricin Inhibitors Targeting Ribosome Binding Using Fragment-Based Methods and Structure-Based Design.
J.Med.Chem., 64, 2021
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8SZ2
 | | Stx2A1 bound to P8 stalk peptide | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, NONAETHYLENE GLYCOL, ... | | 著者 | rudolph, M.J, Li, X.P. | | 登録日 | 2023-05-26 | | 公開日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Structure of Shiga toxin 2 A1 subunit with peptides that bind at the ribosome binding site and inhibit activity
To Be Published
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8CX8
 | | Stx2A1-BTB13086 | | 分子名称: | 1,2-ETHANEDIOL, 5-(4-chlorophenyl)furan-2-carboxylic acid, CHLORIDE ION, ... | | 著者 | Rudolph, M.J, Li, X.P. | | 登録日 | 2022-05-20 | | 公開日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.905 Å) | | 主引用文献 | Stx2A1-BTB13086
To Be Published
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8GCW
 | | Stx2A1(Y77A)-P6 peptide | | 分子名称: | P stalk protein, rRNA N-glycosylase | | 著者 | Rudolph, M.J, Li, X.P. | | 登録日 | 2023-03-03 | | 公開日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structure of the Stx2A1(Y77A) in complex with P6 peptide.
To Be Published
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6X6H
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7U6V
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6OBC
 | | Ricin A chain bound to camelid | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Ricin A chain, ... | | 著者 | Rudolph, M.J. | | 登録日 | 2019-03-20 | | 公開日 | 2020-04-01 | | 最終更新日 | 2020-10-14 | | 実験手法 | X-RAY DIFFRACTION (1.762 Å) | | 主引用文献 | Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site.
J.Mol.Biol., 432, 2020
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6OBE
 | | Ricin A chain bound to VHH antibody V6H8 | | 分子名称: | 1,2-ETHANEDIOL, IMIDAZOLE, NICKEL (II) ION, ... | | 著者 | Rudolph, M.J. | | 登録日 | 2019-03-20 | | 公開日 | 2020-04-01 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.732 Å) | | 主引用文献 | Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site.
J.Mol.Biol., 432, 2020
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6OBO
 | | Ricin A chain bound to VHH antibody V6A6 | | 分子名称: | 1,2-ETHANEDIOL, ACETIC ACID, CALCIUM ION, ... | | 著者 | Rudolph, M.J. | | 登録日 | 2019-03-21 | | 公開日 | 2020-04-01 | | 最終更新日 | 2020-10-14 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site.
J.Mol.Biol., 432, 2020
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6OBG
 | | Ricin A chain bound to VHH antibody V8E6 | | 分子名称: | CHLORIDE ION, Ricin A chain, VHH antibody V8E6, ... | | 著者 | Rudolph, M.J. | | 登録日 | 2019-03-20 | | 公開日 | 2020-04-01 | | 最終更新日 | 2020-10-14 | | 実験手法 | X-RAY DIFFRACTION (1.996 Å) | | 主引用文献 | Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site.
J.Mol.Biol., 432, 2020
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8TAB
 | | RTA-PD00589 | | 分子名称: | 1,2-ETHANEDIOL, 4H,5H-naphtho[1,2-b]thiophene-2-carboxylic acid, CHLORIDE ION, ... | | 著者 | Rudolph, M.J, Tumer, N. | | 登録日 | 2023-06-27 | | 公開日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Structure-based design and optimization of a new class of small molecule inhibitors targeting the P-stalk binding pocket of ricin.
Bioorg.Med.Chem., 100, 2024
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8T9V
 | | RTA-RUNT-59 complex structure | | 分子名称: | (9aP)-7-fluoro-4,5-dihydronaphtho[1,2-b]thiophene-2-carboxylic acid, NONAETHYLENE GLYCOL, Ricin | | 著者 | Rudolph, M.J, Tumer, N. | | 登録日 | 2023-06-26 | | 公開日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.945 Å) | | 主引用文献 | Structure-based design and optimization of a new class of small molecule inhibitors targeting the P-stalk binding pocket of ricin.
Bioorg.Med.Chem., 100, 2024
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8TAD
 | | RTA in complex with inhibitor RUNT-206 | | 分子名称: | (9aM)-5,5-dimethyl-4,5-dihydronaphtho[1,2-b]thiophene-2-carboxylic acid, CHLORIDE ION, NONAETHYLENE GLYCOL, ... | | 著者 | Rudolph, M.J, Tumer, N. | | 登録日 | 2023-06-27 | | 公開日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | | 主引用文献 | Structure-based design and optimization of a new class of small molecule inhibitors targeting the P-stalk binding pocket of ricin.
Bioorg.Med.Chem., 100, 2024
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6OCD
 | | Ricin A chain bound to VHH antibody V6D4 | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, IMIDAZOLE, ... | | 著者 | Rudolph, M.J. | | 登録日 | 2019-03-22 | | 公開日 | 2020-04-01 | | 最終更新日 | 2020-10-14 | | 実験手法 | X-RAY DIFFRACTION (2.103 Å) | | 主引用文献 | Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site.
J.Mol.Biol., 432, 2020
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6OBM
 | | Ricin A chain bound to VHH antibody V6A7 | | 分子名称: | CHLORIDE ION, Ricin A chain, VHH antibody V6A7 | | 著者 | Rudolph, M.J. | | 登録日 | 2019-03-21 | | 公開日 | 2020-04-01 | | 最終更新日 | 2020-10-14 | | 実験手法 | X-RAY DIFFRACTION (2.495 Å) | | 主引用文献 | Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site.
J.Mol.Biol., 432, 2020
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6OCA
 | | Ricin A chain bound to VHH antibody V2G10 | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Ricin A chain, ... | | 著者 | Rudolph, M.J. | | 登録日 | 2019-03-22 | | 公開日 | 2020-04-01 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.113 Å) | | 主引用文献 | Intracellular Neutralization of Ricin Toxin by Single-domain Antibodies Targeting the Active Site.
J.Mol.Biol., 432, 2020
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