7MLN

Crystal structure of ricin A chain in complex with 5-(o-tolyl)thiophene-2-carboxylic acid

Summary for 7MLN

Entry DOI	10.2210/pdb7mln/pdb
Descriptor	Ricin, 5-(2-methylphenyl)thiophene-2-carboxylic acid, GLYCEROL, ... (4 entities in total)
Functional Keywords	ricin chain-a, rta, hydrolase, toxin, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Ricinus communis (Castor bean)
Total number of polymer chains	1
Total formula weight	30562.51
Authors	Harijan, R.K.,Li, X.P.,Cao, B.,Augeri, D.,Bonanno, J.B.,Almo, S.C.,Tumer, N.E.,Schramm, V.L. (deposition date: 2021-04-28, release date: 2022-02-09, Last modification date: 2023-10-18)
Primary citation	Li, X.P.,Harijan, R.K.,Cao, B.,Kahn, J.N.,Pierce, M.,Tsymbal, A.M.,Roberge, J.Y.,Augeri, D.,Tumer, N.E. Synthesis and Structural Characterization of Ricin Inhibitors Targeting Ribosome Binding Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 64:15334-15348, 2021 Cited by PubMed: 34648707 DOI: 10.1021/acs.jmedchem.1c01370 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.52 Å)

Structure validation