8TAD

RTA in complex with inhibitor RUNT-206

Summary for 8TAD

Entry DOI	10.2210/pdb8tad/pdb
Descriptor	Ricin A chain, (9aM)-5,5-dimethyl-4,5-dihydronaphtho[1,2-b]thiophene-2-carboxylic acid, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	n-glycosidase, inhibitor, toxin, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Ricinus communis (castor bean)
Total number of polymer chains	1
Total formula weight	29372.57
Authors	Rudolph, M.J.,Tumer, N. (deposition date: 2023-06-27, release date: 2024-05-01)
Primary citation	Rudolph, M.J.,Dutta, A.,Tsymbal, A.M.,McLaughlin, J.E.,Chen, Y.,Davis, S.A.,Theodorous, S.A.,Pierce, M.,Algava, B.,Zhang, X.,Szekely, Z.,Roberge, J.Y.,Li, X.P.,Tumer, N.E. Structure-based design and optimization of a new class of small molecule inhibitors targeting the P-stalk binding pocket of ricin. Bioorg.Med.Chem., 100:117614-117614, 2024 Cited by PubMed: 38340640 DOI: 10.1016/j.bmc.2024.117614 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.76 Å)

Structure validation