7MLO
Crystal structure of ricin A chain in complex with 5-mesitylthiophene-2-carboxylic acid
Summary for 7MLO
Entry DOI | 10.2210/pdb7mlo/pdb |
Descriptor | Ricin, 5-(2,4,6-trimethylphenyl)thiophene-2-carboxylic acid, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | ricin chain-a, rta, hydrolase, toxin, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Ricinus communis (Castor bean) |
Total number of polymer chains | 2 |
Total formula weight | 60910.82 |
Authors | Harijan, R.K.,Li, X.P.,Cao, B.,Augeri, D.,Bonanno, J.B.,Almo, S.C.,Tumer, N.E.,Schramm, V.L. (deposition date: 2021-04-28, release date: 2022-02-09, Last modification date: 2023-10-18) |
Primary citation | Li, X.P.,Harijan, R.K.,Cao, B.,Kahn, J.N.,Pierce, M.,Tsymbal, A.M.,Roberge, J.Y.,Augeri, D.,Tumer, N.E. Synthesis and Structural Characterization of Ricin Inhibitors Targeting Ribosome Binding Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 64:15334-15348, 2021 Cited by PubMed: 34648707DOI: 10.1021/acs.jmedchem.1c01370 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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