6YXJ
 
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5HOL
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5HIH
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3BJV
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4WUR
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5LC0
 | | Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor | | 分子名称: | N-((S)-3-(4-(aminomethyl)phenyl)-1-(((R)-4-guanidino-1-(5-hydroxy-1,3,2-dioxaborinan-2-yl)butyl)amino)-1-oxopropan-2-yl)benzamide, NS2B-NS3 protease,NS2B-NS3 protease | | 著者 | Lei, J, Hansen, G, Zhang, L.L, Hilgenfeld, R. | | 登録日 | 2016-06-18 | | 公開日 | 2016-07-06 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor.
Science, 353, 2016
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4P16
 | | Crystal structure of the papain-like protease of Middle-East Respiratory Syndrome coronavirus | | 分子名称: | ORF1a, ZINC ION | | 著者 | Lei, J, Mesters, J.R, Ma, Q, Hilgenfeld, R. | | 登録日 | 2014-02-25 | | 公開日 | 2014-05-07 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features.
Antiviral Res., 109C, 2014
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3CZC
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3L8R
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3RK6
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5NGN
 | | Lybatide 2, a cystine-rich peptide from Lycium barbarum | | 分子名称: | ACETONITRILE, GLYCEROL, TETRAETHYLENE GLYCOL, ... | | 著者 | Lei, J, Tan, W.L, Sakai, N, Hilgenfeld, R. | | 登録日 | 2017-03-18 | | 公開日 | 2017-07-26 | | 最終更新日 | 2018-04-11 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | Lybatides from Lycium barbarum Contain An Unusual Cystine-stapled Helical Peptide Scaffold.
Sci Rep, 7, 2017
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3D3F
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3F7J
 | | B.subtilis YvgN | | 分子名称: | NITRATE ION, POTASSIUM ION, YvgN protein | | 著者 | Zhou, Y.F, Lei, J, Liang, Y.H, Su, X.-D. | | 登録日 | 2008-11-09 | | 公開日 | 2008-11-25 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural and biochemical analyses of YvgN and YtbE from Bacillus subtilis
Protein Sci., 18, 2009
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5VKG
 | | Solution-state NMR structural ensemble of human Tsg101 UEV in complex with tenatoprazole | | 分子名称: | 4-methoxy-1-(5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)-3,5-dimethyl-2-(sulfanylmethyl)pyridin-1-ium, Tumor susceptibility gene 101 protein | | 著者 | Strickland, M, Ehrlich, L.S, Watanabe, S, Khan, M, Strub, M.-P, Luan, C.H, Powell, M.D, Leis, J, Tjandra, N, Carter, C. | | 登録日 | 2017-04-21 | | 公開日 | 2017-11-15 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Tsg101 chaperone function revealed by HIV-1 assembly inhibitors.
Nat Commun, 8, 2017
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1A94
 | | STRUCTURAL BASIS FOR SPECIFICITY OF RETROVIRAL PROTEASES | | 分子名称: | N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide, PROTEASE | | 著者 | Wu, J, Adomat, J.M, Ridky, T.W, Louis, J.M, Leis, J, Harrison, R.W, Weber, I.T. | | 登録日 | 1998-04-16 | | 公開日 | 1999-01-13 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis for specificity of retroviral proteases.
Biochemistry, 37, 1998
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1BAI
 | | Crystal structure of Rous sarcoma virus protease in complex with inhibitor | | 分子名称: | N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide, PROTEASE | | 著者 | Wu, J, Adomat, J.M, Ridky, T.W, Louis, J.M, Leis, J, Harrison, R.W, Weber, I.T. | | 登録日 | 1998-04-17 | | 公開日 | 1999-01-13 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for specificity of retroviral proteases.
Biochemistry, 37, 1998
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4V6L
 | | Structural insights into cognate vs. near-cognate discrimination during decoding. | | 分子名称: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | 著者 | Agirrezabala, X, Schreiner, E, Trabuco, L.G, Lei, J, Ortiz-Meoz, R.F, Schulten, K, Green, R, Frank, J. | | 登録日 | 2011-01-07 | | 公開日 | 2014-07-09 | | 最終更新日 | 2024-02-28 | | 実験手法 | ELECTRON MICROSCOPY (13.2 Å) | | 主引用文献 | Structural insights into cognate versus near-cognate discrimination during decoding.
Embo J., 30, 2011
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4V6K
 | | Structural insights into cognate vs. near-cognate discrimination during decoding. | | 分子名称: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | 著者 | Agirrezabala, X, Schreiner, E, Trabuco, L.G, Lei, J, Ortiz-Meoz, R.F, Schulten, K, Green, R, Frank, J. | | 登録日 | 2011-01-07 | | 公開日 | 2014-07-09 | | 最終更新日 | 2024-02-28 | | 実験手法 | ELECTRON MICROSCOPY (8.25 Å) | | 主引用文献 | Structural insights into cognate versus near-cognate discrimination during decoding.
Embo J., 30, 2011
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8WGX
 | | Cryo-EM structure of inward-open state human norepinephrine transporter NET bound with norepinephrine in nanodisc. | | 分子名称: | L-NOREPINEPHRINE, Sodium-dependent noradrenaline transporter | | 著者 | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | | 登録日 | 2023-09-22 | | 公開日 | 2024-07-31 | | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | | 主引用文献 | Molecular basis of human noradrenaline transporter reuptake and inhibition.
Nature, 2024
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8WGR
 | | Cryo-EM structure of inward-open state human norepinephrine transporter NET bound with antidepressant desipramine in KCl condition. | | 分子名称: | 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE, CHLORIDE ION, POTASSIUM ION, ... | | 著者 | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | | 登録日 | 2023-09-22 | | 公開日 | 2024-07-31 | | 実験手法 | ELECTRON MICROSCOPY (2.75 Å) | | 主引用文献 | Molecular basis of human noradrenaline transporter reuptake and inhibition.
Nature, 2024
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6M49
 | | cryo-EM structure of Scap/Insig complex in the present of 25-hydroxyl cholesterol. | | 分子名称: | 25-HYDROXYCHOLESTEROL, Insulin-induced gene 2 protein, Sterol regulatory element-binding protein cleavage-activating protein,Sterol regulatory element-binding protein cleavage-activating protein | | 著者 | Yan, R, Cao, P, Song, W, Qian, H, Du, X, Coates, H.W, Zhao, X, Li, Y, Gao, S, Gong, X, Liu, X, Sui, J, Lei, J, Yang, H, Brown, A.J, Zhou, Q, Yan, C, Yan, N. | | 登録日 | 2020-03-06 | | 公開日 | 2021-01-20 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols.
Science, 371, 2021
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8Z1L
 | | Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant atomoxetine in an outward-open state at resolution of 3.4 angstrom. | | 分子名称: | (3R)-N-methyl-3-(2-methylphenoxy)-3-phenyl-propan-1-amine, CHLORIDE ION, Sodium-dependent noradrenaline transporter | | 著者 | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | | 登録日 | 2024-04-11 | | 公開日 | 2024-07-31 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Molecular basis of human noradrenaline transporter reuptake and inhibition
Nature, 2024
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6LGM
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6LYY
 | | Cryo-EM structure of the human MCT1/Basigin-2 complex in the presence of anti-cancer drug candidate AZD3965 in the outward-open conformation. | | 分子名称: | 3-methyl-5-[[(4~{R})-4-methyl-4-oxidanyl-1,2-oxazolidin-2-yl]carbonyl]-6-[[5-methyl-3-(trifluoromethyl)-1~{H}-pyrazol-4-yl]methyl]-1-propan-2-yl-thieno[2,3-d]pyrimidine-2,4-dione, Basigin, Monocarboxylate transporter 1 | | 著者 | Wang, N, Jiang, X, Zhang, S, Zhu, A, Yuan, Y, Lei, J, Yan, C. | | 登録日 | 2020-02-16 | | 公開日 | 2020-12-23 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates.
Cell, 184, 2021
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7OXG
 | | ttSlyD FKBP domain with M8A pseudo-wild-type S2 peptide | | 分子名称: | 30S ribosomal protein S2, CHLORIDE ION, IMIDAZOLE, ... | | 著者 | Pazicky, S, Lei, J, Loew, C. | | 登録日 | 2021-06-22 | | 公開日 | 2022-03-16 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Impact of distant peptide substrate residues on enzymatic activity of SlyD.
Cell.Mol.Life Sci., 79, 2022
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