7S7M
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![BU of 7s7m by Molmil](/molmil-images/mine/7s7m) | Complex of tissue inhibitor of metalloproteinases-1 (TIMP-1) mutant (L34G/M66D/T98G/P131S/Q153N) with matrix metalloproteinase-3 catalytic domain (MMP-3cd) | 分子名称: | CALCIUM ION, Metalloproteinase inhibitor 1, Stromelysin-1, ... | 著者 | Coban, M, Raeeszadeh-Sarmazdeh, M, Sankaran, B, Hockla, A, Radisky, E.S. | 登録日 | 2021-09-16 | 公開日 | 2022-03-16 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10. J.Biol.Chem., 298, 2022
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7S7L
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![BU of 7s7l by Molmil](/molmil-images/mine/7s7l) | Complex of tissue inhibitor of metalloproteinases-1 (TIMP-1) mutant (L34G/M66S/E67Y/L133N/S155L) with matrix metalloproteinase-3 catalytic domain (MMP-3cd) | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, CALCIUM ION, ... | 著者 | Coban, M, Raeeszadeh-Sarmazdeh, M, Hockla, A, Sankaran, B, Radisky, E.S. | 登録日 | 2021-09-16 | 公開日 | 2022-03-16 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10. J.Biol.Chem., 298, 2022
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6BX8
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![BU of 6bx8 by Molmil](/molmil-images/mine/6bx8) | Human Mesotrypsin (PRSS3) Complexed with Tissue Factor Pathway Inhibitor Variant (TFPI1-KD1-K15R-I17C-I34C) | 分子名称: | SULFATE ION, Tissue factor pathway inhibitor, Trypsin-3 | 著者 | Coban, M, Sankaran, B, Cohen, I, Hockla, A, Papo, N, Radisky, E.S. | 登録日 | 2017-12-18 | 公開日 | 2019-02-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin. J. Biol. Chem., 294, 2019
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5JBT
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![BU of 5jbt by Molmil](/molmil-images/mine/5jbt) | Mesotrypsin in complex with cleaved amyloid precursor like protein 2 inhibitor (APLP2) | 分子名称: | Amyloid-like protein 2, CALCIUM ION, PRSS3 protein, ... | 著者 | Kayode, O, Wang, R, Pendlebury, D, Soares, A, Radisky, E.S. | 登録日 | 2016-04-13 | 公開日 | 2016-11-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | An Acrobatic Substrate Metamorphosis Reveals a Requirement for Substrate Conformational Dynamics in Trypsin Proteolysis. J. Biol. Chem., 291, 2016
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2RA3
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![BU of 2ra3 by Molmil](/molmil-images/mine/2ra3) | Human cationic trypsin complexed with bovine pancreatic trypsin inhibitor (BPTI) | 分子名称: | CALCIUM ION, Pancreatic trypsin inhibitor, SULFATE ION, ... | 著者 | Salameh, M.A, Soares, A.S, Radisky, E.S. | 登録日 | 2007-09-14 | 公開日 | 2007-12-11 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | Structural Basis for Accelerated Cleavage of Bovine Pancreatic Trypsin Inhibitor (BPTI) by Human Mesotrypsin. J.Biol.Chem., 283, 2008
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6HAR
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![BU of 6har by Molmil](/molmil-images/mine/6har) | Crystal structure of Mesotrypsin in complex with APPI-M17C/I18F/F34C | 分子名称: | 1,2-ETHANEDIOL, Amyloid-beta A4 protein, CALCIUM ION, ... | 著者 | Shahar, A, Cohen, I, Radisky, E, Papo, N. | 登録日 | 2018-08-08 | 公開日 | 2019-02-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.497 Å) | 主引用文献 | Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin. J.Biol.Chem., 294, 2019
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4WWY
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![BU of 4wwy by Molmil](/molmil-images/mine/4wwy) | human cationic trypsin G193R mutant in complex with bovine pancreatic trypsin inhibitor | 分子名称: | CALCIUM ION, Pancreatic trypsin inhibitor, SULFATE ION, ... | 著者 | Alloy, A, Kayode, O, Soares, A.S, Wang, R, Radisky, E.S. | 登録日 | 2014-11-12 | 公開日 | 2015-07-22 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Mesotrypsin Has Evolved Four Unique Residues to Cleave Trypsin Inhibitors as Substrates. J.Biol.Chem., 290, 2015
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4WXV
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![BU of 4wxv by Molmil](/molmil-images/mine/4wxv) | Human cationic trypsin K97D mutant in complex with bovine pancreatic trypsin inhibitor (BPTI) | 分子名称: | CALCIUM ION, Pancreatic trypsin inhibitor, SULFATE ION, ... | 著者 | Alloy, A, Kayode, O, Soares, A.S, Wang, R, Radisky, E.S. | 登録日 | 2014-11-14 | 公開日 | 2015-07-22 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Mesotrypsin Has Evolved Four Unique Residues to Cleave Trypsin Inhibitors as Substrates. J.Biol.Chem., 290, 2015
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6GFI
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![BU of 6gfi by Molmil](/molmil-images/mine/6gfi) | Structure of Human Mesotrypsin in complex with APPI variant T11V/M17R/I18F/F34V | 分子名称: | 1,2-ETHANEDIOL, Amyloid-beta A4 protein, PRSS3 protein | 著者 | Shahar, A, Cohen, I, Radisky, E, Papo, N, Naftaly, S. | 登録日 | 2018-04-30 | 公開日 | 2018-09-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries. Nat Commun, 9, 2018
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5NX1
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![BU of 5nx1 by Molmil](/molmil-images/mine/5nx1) | Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy | 分子名称: | Amyloid-beta A4 protein, Kallikrein-6 | 著者 | Shahar, A, Sananes, A, Radisky, E.S, Papo, N. | 登録日 | 2017-05-09 | 公開日 | 2018-05-30 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.853 Å) | 主引用文献 | A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering. J.Biol.Chem., 293, 2018
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5NX3
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![BU of 5nx3 by Molmil](/molmil-images/mine/5nx3) | Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy | 分子名称: | Amyloid-beta A4 protein, Kallikrein-6 | 著者 | Shahar, A, Sananes, A, Radisky, E.S, Papo, N. | 登録日 | 2017-05-09 | 公開日 | 2018-05-30 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.296 Å) | 主引用文献 | A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering. J.Biol.Chem., 293, 2018
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4U32
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![BU of 4u32 by Molmil](/molmil-images/mine/4u32) | Human mesotrypsin complexed with HAI-2 Kunitz domain 1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Kunitz-type protease inhibitor 2, ... | 著者 | Wang, R, Soares, A.S, Radisky, E.S. | 登録日 | 2014-07-18 | 公開日 | 2014-10-15 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Sequence and Conformational Specificity in Substrate Recognition: SEVERAL HUMAN KUNITZ PROTEASE INHIBITOR DOMAINS ARE SPECIFIC SUBSTRATES OF MESOTRYPSIN. J.Biol.Chem., 289, 2014
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4U30
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![BU of 4u30 by Molmil](/molmil-images/mine/4u30) | |
2R9P
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![BU of 2r9p by Molmil](/molmil-images/mine/2r9p) | |
5C67
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![BU of 5c67 by Molmil](/molmil-images/mine/5c67) | |
3P92
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![BU of 3p92 by Molmil](/molmil-images/mine/3p92) | |
3P95
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![BU of 3p95 by Molmil](/molmil-images/mine/3p95) | |