7S7L

Complex of tissue inhibitor of metalloproteinases-1 (TIMP-1) mutant (L34G/M66S/E67Y/L133N/S155L) with matrix metalloproteinase-3 catalytic domain (MMP-3cd)

Summary for 7S7L

Entry DOI	10.2210/pdb7s7l/pdb
Descriptor	Stromelysin-1, Metalloproteinase inhibitor 1, CALCIUM ION, ... (10 entities in total)
Functional Keywords	metalloproteinase, metalloproteinase inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	40766.08
Authors	Coban, M.,Raeeszadeh-Sarmazdeh, M.,Hockla, A.,Sankaran, B.,Radisky, E.S. (deposition date: 2021-09-16, release date: 2022-03-16, Last modification date: 2023-10-18)
Primary citation	Raeeszadeh-Sarmazdeh, M.,Coban, M.,Mahajan, S.,Hockla, A.,Sankaran, B.,Downey, G.P.,Radisky, D.C.,Radisky, E.S. Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10. J.Biol.Chem., 298:101654-101654, 2022 Cited by PubMed: 35101440 DOI: 10.1016/j.jbc.2022.101654 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.34 Å)

Structure validation