7S7L
Complex of tissue inhibitor of metalloproteinases-1 (TIMP-1) mutant (L34G/M66S/E67Y/L133N/S155L) with matrix metalloproteinase-3 catalytic domain (MMP-3cd)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Stromelysin-1 | polymer | 173 | 19416.5 | 1 | UniProt (P08254) Pfam (PF00413) | Homo sapiens (Human) | SL-1,Matrix metalloproteinase-3,MMP-3,Transin-1 |
| 2 | B (B) | Metalloproteinase inhibitor 1 | polymer | 184 | 20693.7 | 1 | UniProt (P01033) Pfam (PF00965) | Homo sapiens (Human) | Erythroid-potentiating activity,EPA,Fibroblast collagenase inhibitor,Collagenase inhibitor,Tissue inhibitor of metalloproteinases 1,TIMP-1 |
| 3 | C, D, E (A) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 4 | F, G (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | H (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | I (A) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 7 | J (B) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 8 | K (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 9 | L (B) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 10 | M, N (A, B) | water | water | 18.0 | 79 | Chemie (HOH) |
Sequence modifications
B: 1 - 184 (UniProt: P01033)
| PDB | External Database | Details |
|---|---|---|
| Gly 34 | Leu 57 | engineered mutation |
| Ser 66 | Met 89 | engineered mutation |
| Tyr 67 | Glu 90 | engineered mutation |
| Asn 133 | Leu 156 | engineered mutation |
| Leu 155 | Ser 178 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 40110.2 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 655.8 | |
| All* | Total formula weight | 40766.1 |
