5I6J
 
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6ZG1
 | | SARM1 SAM1-2 domains | | 分子名称: | 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Sporny, M, Guez-Haddad, J, Khazma, T, Yaron, A, Dessau, M, Mim, C, Isupov, M.N, Zalk, R, Hons, M, Opatowsky, Y. | | 登録日 | 2020-06-18 | | 公開日 | 2020-11-11 | | 最終更新日 | 2020-12-09 | | 実験手法 | ELECTRON MICROSCOPY (3.77 Å) | | 主引用文献 | Structural basis for SARM1 inhibition and activation under energetic stress.
Elife, 9, 2020
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6ZFX
 | | hSARM1 GraFix-ed | | 分子名称: | (~{E})-4-methylnon-4-enedial, NAD(+) hydrolase SARM1 | | 著者 | Sporny, M, Guez-Haddad, J, Khazma, T, Yaron, A, Dessau, M, Mim, C, Isupov, M.N, Zalk, R, Hons, M, Opatowsky, Y. | | 登録日 | 2020-06-18 | | 公開日 | 2020-11-18 | | 最終更新日 | 2022-11-09 | | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | | 主引用文献 | Structural basis for SARM1 inhibition and activation under energetic stress.
Elife, 9, 2020
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7QG0
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7ANW
 | | hSARM1 NAD+ complex | | 分子名称: | NAD(+) hydrolase SARM1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Sporny, M, Guez-Haddad, J, Khazma, T, Yaron, A, Mim, C, Isupov, M.N, Zalk, R, Dessau, M, Hons, M, Opatowsky, Y. | | 登録日 | 2020-10-13 | | 公開日 | 2020-11-11 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | | 主引用文献 | Structural basis for SARM1 inhibition and activation under energetic stress.
Elife, 9, 2020
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5I7D
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5I6R
 | | Crystal Structure of srGAP2 F-BARx WT Form-1 | | 分子名称: | ACETATE ION, D-MALATE, SLIT-ROBO Rho GTPase-activating protein 2, ... | | 著者 | Sporny, M, Guez-Haddad, J, Isupov, M.N, Opatowsky, Y. | | 登録日 | 2016-02-16 | | 公開日 | 2017-08-30 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Structural Basis for srGAP2 Membrane Interactions, and Antagonism by the Human Specific Paralog srGAP2C
To Be Published
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6ZG0
 | | SARM1 SAM1-2 domains | | 分子名称: | 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Sporny, M, Guez-Haddad, J, Khazma, T, Yaron, A, Dessau, M, Mim, C, Isupov, M.N, Zalk, R, Hons, M, Opatowsky, Y. | | 登録日 | 2020-06-18 | | 公開日 | 2020-11-11 | | 最終更新日 | 2020-12-09 | | 実験手法 | ELECTRON MICROSCOPY (7.7 Å) | | 主引用文献 | Structural basis for SARM1 inhibition and activation under energetic stress.
Elife, 9, 2020
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2F4S
 | | A-site RNA in complex with neamine | | 分子名称: | (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside, 5'-R(P*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' | | 著者 | Murray, J.B, Meroueh, S.O, Russell, R.J, Lentzen, G, Haddad, J, Mobashery, S. | | 登録日 | 2005-11-24 | | 公開日 | 2006-05-02 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site
Chem.Biol., 13, 2006
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2F4T
 | | Asite RNA + designer antibiotic | | 分子名称: | (2R)-4-AMINO-N-{(1R,2S,3R,4R,5S)-5-AMINO-2-{2-[(2-AMINOETHYL)AMINO]ETHOXY}-4-[(2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-3-HYDROXYCYCLOHEXYL}-2-HYDROXYBUTANAMIDE, 5'-R(*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3', 5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' | | 著者 | Murray, J.B, Meroueh, S.O, Russell, R.J, Lentzen, G, Haddad, J, Mobashery, S. | | 登録日 | 2005-11-24 | | 公開日 | 2006-05-02 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site
Chem.Biol., 13, 2006
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2F4U
 | | Asite RNA + designer antibiotic | | 分子名称: | (2R)-4-AMINO-N-((1R,2S,3R,4R,5S)-5-AMINO-4-[(2-AMINO-2-DEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-2-{2-[(3-AMINOPROPYL)AMINO]ETHOXY}-3-HYDROXYCYCLOHEXYL)-2-HYDROXYBUTANAMIDE, 5'-R(*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' | | 著者 | Murray, J.B, Meroueh, S.O, Russell, R.J, Lentzen, G, Haddad, J, Mobashery, S. | | 登録日 | 2005-11-24 | | 公開日 | 2006-05-02 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site
Chem.Biol., 13, 2006
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2F4V
 | | 30S ribosome + designer antibiotic | | 分子名称: | (2R)-4-AMINO-N-{(1R,2S,3R,4R,5S)-5-AMINO-2-{2-[(2-AMINOETHYL)AMINO]ETHOXY}-4-[(2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-3-HYDROXYCYCLOHEXYL}-2-HYDROXYBUTANAMIDE, (2S,4S,4AR,5AS,6S,11R,11AS,12R,12AR)-7-CHLORO-4-(DIMETHYLAMINO)-6,10,11,12-TETRAHYDROXY-1,3-DIOXO-1,2,3,4,4A,5,5A,6,11,11A,12,12A-DODECAHYDROTETRACENE-2-CARBOXAMIDE, 16S ribosomal RNA, ... | | 著者 | Murray, J.B, Meroueh, S.O, Russell, R.J, Lentzen, G, Haddad, J, Mobashery, S. | | 登録日 | 2005-11-24 | | 公開日 | 2006-07-04 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | Interactions of designer antibiotics and the bacterial ribosome aminoacyl-tRNA site
Chem.Biol., 13, 2006
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4RUG
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5NOI
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4RTT
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8P2L
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8P2M
 | | C. elegans TIR-1 protein. | | 分子名称: | NAD(+) hydrolase tir-1 | | 著者 | Isupov, M.N, Opatowsky, Y. | | 登録日 | 2023-05-16 | | 公開日 | 2023-09-06 | | 実験手法 | ELECTRON MICROSCOPY (3.82 Å) | | 主引用文献 | Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans.
Cell Rep, 42, 2023
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6IAA
 | | hRobo2 ectodomain | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Roundabout homolog 2, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Barak, R, Isupov, N.M, Opatowsky, Y. | | 登録日 | 2018-11-26 | | 公開日 | 2019-03-13 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Structural Principles in Robo Activation and Auto-inhibition.
Cell, 177, 2019
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6I9S
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1O9M
 | | The Complex of a novel antibiotic with the Aminoacyl Site of the Bacterial Ribosome Revealed by X-Ray Crystallography. | | 分子名称: | 1-(AMINOETHYL)AMINO-4-AMINOBUTANE, 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranose, 4-AMINO-2-HYDROXYBUTANOIC ACID, ... | | 著者 | Russell, R, Murray, J.B. | | 登録日 | 2002-12-17 | | 公開日 | 2003-03-27 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The Complex of a Designer Antibiotic with a Model Aminoacyl Site of the 30S Ribosomal Subunit Revealed by X-Ray Crystallography
J.Am.Chem.Soc., 125, 2003
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6QWV
 | | SARM1 SAM1-2 domains | | 分子名称: | 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Sporny, M, Isupov, N.M, Opatowsky, Y. | | 登録日 | 2019-03-06 | | 公開日 | 2019-07-03 | | 最終更新日 | 2019-09-18 | | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | | 主引用文献 | Structural Evidence for an Octameric Ring Arrangement of SARM1.
J.Mol.Biol., 431, 2019
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