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BU of 6eux by Molmil

Structure of the midlink and cap-binding domains of influenza B polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor
分子名称:	(2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, Polymerase basic protein 2
著者	Cusack, S, Gaudon, S.
登録日	2017-10-31
公開日	2017-12-13
最終更新日	2024-10-23
実験手法	X-RAY DIFFRACTION (2.05 Å)
主引用文献	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

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BU of 5fml by Molmil

Crystal structure of the endonuclease from the PA subunit of influenza B virus bound to the PB2 subunit NLS peptide
分子名称:	GLYCEROL, MAGNESIUM ION, PA SUBUNIT OF INFLUENZA B POLYMERASE, ...
著者	Guilligay, D, Gaudon, S, Cusack, S.
登録日	2015-11-06
公開日	2016-01-13
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of Pb2 Domains. Mol.Cell, 61, 2016

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BU of 6euy by Molmil

Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor
分子名称:	(2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, Polymerase basic protein 2, SULFATE ION
著者	Cusack, S, Gaudon, S.
登録日	2017-10-31
公開日	2017-12-13
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (3 Å)
主引用文献	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

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BU of 6euw by Molmil

Crystal structure of the cap-binding domain of the PB2 subunit of influenza A/H5N1 polymerase bound to an azaindazole inhibitor
分子名称:	(2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, GLYCEROL, Polymerase basic protein 2
著者	Cusack, S, Gaudon, S.
登録日	2017-10-31
公開日	2017-12-13
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (1 Å)
主引用文献	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

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BU of 6evj by Molmil

Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter and capped RNA primer
分子名称:	Polymerase acidic protein, Polymerase basic protein 2, RNA (5'-D((GDM))-R(PAPAPU)-3'), ...
著者	Pflug, A, Cusack, S.
登録日	2017-11-01
公開日	2017-12-13
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (3.9 Å)
主引用文献	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

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BU of 5ize by Molmil

Hantaan virus L protein cap-snatching endonuclease
分子名称:	MANGANESE (III) ION, RNA-directed RNA polymerase L
著者	Reguera, J, Cusack, S.
登録日	2016-03-25
公開日	2016-06-29
最終更新日	2024-11-06
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases. Plos Pathog., 12, 2016

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BU of 5izh by Molmil

Lassa virus L protein cap-snatching endonuclease. apo form
分子名称:	RNA-directed RNA polymerase L
著者	Reguera, J, Cusack, S.
登録日	2016-03-25
公開日	2016-06-29
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.85 Å)
主引用文献	Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases. Plos Pathog., 12, 2016

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BU of 5j1n by Molmil

Lassa virus L protein cap-snatching endonuclease. Bound to one manganese ion
分子名称:	(4S)-2-METHYL-2,4-PENTANEDIOL, MANGANESE (III) ION, RNA-directed RNA polymerase L
著者	Reguera, J, Cusack, S.
登録日	2016-03-29
公開日	2016-06-29
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.09 Å)
主引用文献	Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases. Plos Pathog., 12, 2016

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BU of 5j1p by Molmil

Lassa virus L protein cap-snatching endonuclease. Bound to two manganese ions
分子名称:	MANGANESE (III) ION, RNA-directed RNA polymerase L
著者	Reguera, J, Cusack, S.
登録日	2016-03-29
公開日	2016-06-29
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (2.36 Å)
主引用文献	Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases. Plos Pathog., 12, 2016

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BU of 5epi by Molmil

CRYSTAL STRUCTURE OF INFLUENZA B POLYMERASE WITH BOUND 5' CRNA EXHIBITS A NOVEL DOMAIN ARRANGEMENT
分子名称:	CRNA 5' END, Polymerase acidic protein, Polymerase basic protein 2, ...
著者	Guilligay, D, Cusack, S.
登録日	2015-11-11
公開日	2016-01-13
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (4.1 Å)
主引用文献	Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains. Mol.Cell, 61, 2016

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BU of 5fmz by Molmil

Crystal structure of Influenza B polymerase with bound 5' vRNA
分子名称:	5'-R(APGPUPAPGPUPAPAPCPAPAPGP)-3', POLYMERASE ACIDIC PROTEIN, POLYMERASE BASIC PROTEIN 2, ...
著者	Guilligay, D, Cusack, S.
登録日	2015-11-10
公開日	2016-01-13
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (3.4 Å)
主引用文献	Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of Pb2 Domains. Mol.Cell, 61, 2016

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BU of 5fmq by Molmil

Crystal structure of the mid, cap-binding, mid-link and 627 domains from avian influenza A virus polymerase PB2 subunit bound to M7GTP H32 crystal form
分子名称:	7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, INFLUENZA A PB2 SUBUNIT
著者	Thierry, E, Pflug, A, Hart, D, Cusack, S.
登録日	2015-11-07
公開日	2016-01-13
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (3.1 Å)
主引用文献	Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of Pb2 Domains. Mol.Cell, 61, 2016

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BU of 6euv by Molmil

Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindole cap-binding inhibitor (VX-787)
分子名称:	(2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, NICKEL (II) ION, Polymerase basic protein 2
著者	Cusack, S, Lethier, M.
登録日	2017-10-31
公開日	2017-12-13
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

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BU of 6evk by Molmil

Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter and cap analogue m7GTP
分子名称:	7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION, Polymerase acidic protein, ...
著者	Pflug, A, Cusack, S.
登録日	2017-11-01
公開日	2017-12-13
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (2.9 Å)
主引用文献	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

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BU of 5fmm by Molmil

crystal structure of the mid, cap-binding, mid-link and 627 domains from avian influenza a virus polymerase PB2 subunit bound to M7GTP
分子名称:	7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, CITRATE ANION, INFLUENZA A PB2 SUBUNIT
著者	Thierry, E, Pflug, A, Hart, D, Cusack, S.
登録日	2015-11-06
公開日	2016-01-13
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of Pb2 Domains. Mol.Cell, 61, 2016

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BU of 6ggs by Molmil

Structure of RIP2 CARD filament
分子名称:	Receptor-interacting serine/threonine-protein kinase 2
著者	Pellegrini, E, Cusack, S, Desfosses, A, Schoehn, G, Malet, H, Gutsche, I, Sachse, C, Hons, M.
登録日	2018-05-03
公開日	2018-10-17
最終更新日	2024-05-15
実験手法	ELECTRON MICROSCOPY (3.94 Å)
主引用文献	RIP2 filament formation is required for NOD2 dependent NF-kappa B signalling. Nat Commun, 9, 2018

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BU of 6gfj by Molmil

Structure of RIP2 CARD domain fused to crystallisable MBP tag
分子名称:	Sugar ABC transporter substrate-binding protein,Receptor-interacting serine/threonine-protein kinase 2, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
著者	Pellegrini, E, Cusack, S.
登録日	2018-04-30
公開日	2019-03-13
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (3.3 Å)
主引用文献	RIP2 filament formation is required for NOD2 dependent NF-kappa B signalling. Nat Commun, 9, 2018

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件を2024-11-06に公開中

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