Structure of RIP2 CARD filament

Summary for 6GGS

EMDB information4399
DescriptorReceptor-interacting serine/threonine-protein kinase 2 (1 entity in total)
Functional Keywordscard, rip2, filament, helical, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains10
Total molecular weight125723.68
Pellegrini, E.,Cusack, S.,Desfosses, A.,Schoehn, G.,Malet, H.,Gutsche, I.,Sachse, C.,Hons, M. (deposition date: 2018-05-03, release date: 2018-10-17)
Primary citation
Pellegrini, E.,Desfosses, A.,Wallmann, A.,Schulze, W.M.,Rehbein, K.,Mas, P.,Signor, L.,Gaudon, S.,Zenkeviciute, G.,Hons, M.,Malet, H.,Gutsche, I.,Sachse, C.,Schoehn, G.,Oschkinat, H.,Cusack, S.
RIP2 filament formation is required for NOD2 dependent NF-kappa B signalling.
Nat Commun, 9:4043-4043, 2018
PubMed: 30279485 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-018-06451-3
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers130 2.5%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures