5O9G
| Structure of nucleosome-Chd1 complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Chromo domain-containing protein 1, ... | 著者 | Farnung, L, Vos, S.M, Wigge, C, Cramer, P. | 登録日 | 2017-06-19 | 公開日 | 2017-10-11 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Nucleosome-Chd1 structure and implications for chromatin remodelling. Nature, 550, 2017
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6I84
| Structure of transcribing RNA polymerase II-nucleosome complex | 分子名称: | DNA (158-MER), DNA (170-MER), DNA-directed RNA polymerase II subunit RPB1, ... | 著者 | Farnung, L, Vos, S.M, Cramer, P. | 登録日 | 2018-11-19 | 公開日 | 2019-01-02 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Structure of transcribing RNA polymerase II-nucleosome complex. Nat Commun, 9, 2018
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7NKY
| RNA Polymerase II-Spt4/5-nucleosome-FACT structure | 分子名称: | Chromatin elongation factor SPT4, DNA (138-MER), DNA (148-MER), ... | 著者 | Farnung, L, Ochmann, M, Engeholm, M, Cramer, P. | 登録日 | 2021-02-19 | 公開日 | 2021-07-07 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural basis of nucleosome transcription mediated by Chd1 and FACT. Nat.Struct.Mol.Biol., 28, 2021
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7NKX
| RNA polymerase II-Spt4/5-nucleosome-Chd1 structure | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Chromatin elongation factor SPT4, ... | 著者 | Farnung, L, Ochmann, M, Engeholm, M, Cramer, P. | 登録日 | 2021-02-19 | 公開日 | 2021-08-25 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis of nucleosome transcription mediated by Chd1 and FACT. Nat.Struct.Mol.Biol., 28, 2021
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8A40
| Structure of mammalian Pol II-TFIIS elongation complex | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... | 著者 | Farnung, L, Ochmann, M, Garg, G, Vos, S.M, Cramer, P. | 登録日 | 2022-06-09 | 公開日 | 2023-08-23 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure of a backtracked hexasomal intermediate of nucleosome transcription. Mol.Cell, 82, 2022
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8A3Y
| Structure of mammalian Pol II-DSIF-SPT6-PAF1-TFIIS-hexasome elongation complex | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... | 著者 | Farnung, L, Ochmann, M, Garg, G, Vos, S.M, Cramer, P. | 登録日 | 2022-06-09 | 公開日 | 2024-07-31 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure of a backtracked hexasomal intermediate of nucleosome transcription. Mol.Cell, 82, 2022
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6RYU
| Nucleosome-CHD4 complex structure (two CHD4 copies) | 分子名称: | Chromodomain-helicase-DNA-binding protein 4,CHD4,Chromodomain-helicase-DNA-binding protein 4, DNA (149-MER), Histone H2A type 1, ... | 著者 | Farnung, L, Ochmann, M, Cramer, P. | 登録日 | 2019-06-12 | 公開日 | 2020-07-15 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Nucleosome-CHD4 chromatin remodeller structure maps human disease mutations. Elife, 9, 2020
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6RYR
| Nucleosome-CHD4 complex structure (single CHD4 copy) | 分子名称: | Chromodomain-helicase-DNA-binding protein 4,Chromodomain-helicase-DNA-binding protein 4,Chromodomain-helicase-DNA-binding protein 4, DNA (149-MER), Histone H2A type 1, ... | 著者 | Farnung, L, Ochmann, M, Cramer, P. | 登録日 | 2019-06-11 | 公開日 | 2020-07-15 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Nucleosome-CHD4 chromatin remodeller structure maps human disease mutations. Elife, 9, 2020
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8TOF
| Rpd3S bound to an H3K36Cme3 modified nucleosome | 分子名称: | Chromatin modification-related protein EAF3, DNA (176-MER), Histone H2A, ... | 著者 | Markert, J.W, Vos, S.M, Farnung, L. | 登録日 | 2023-08-03 | 公開日 | 2024-01-17 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structure of the complete Saccharomyces cerevisiae Rpd3S-nucleosome complex. Nat Commun, 14, 2023
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8F86
| SIRT6 bound to an H3K9Ac nucleosome | 分子名称: | DNA (148-MER), Histone H2A type 1, Histone H2B, ... | 著者 | Markert, J, Whedon, S, Wang, Z, Cole, P, Farnung, L. | 登録日 | 2022-11-21 | 公開日 | 2023-04-05 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural Basis of Sirtuin 6-Catalyzed Nucleosome Deacetylation. J.Am.Chem.Soc., 145, 2023
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6YYT
| Structure of replicating SARS-CoV-2 polymerase | 分子名称: | RNA product, ZINC ION, nsp12, ... | 著者 | Hillen, H.S, Kokic, G, Farnung, L, Dienemann, C, Tegunov, D, Cramer, P. | 登録日 | 2020-05-06 | 公開日 | 2020-05-13 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structure of replicating SARS-CoV-2 polymerase. Nature, 584, 2020
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4NST
| Crystal structure of human Cdk12/Cyclin K in complex with ADP-aluminum fluoride | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, ... | 著者 | Boesken, C.A, Farnung, L, Anand, K, Geyer, M. | 登録日 | 2013-11-29 | 公開日 | 2014-03-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The structure and substrate specificity of human Cdk12/Cyclin K. Nat Commun, 5, 2014
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5OT2
| RNA polymerase II elongation complex in the presence of 3d-Napht-A | 分子名称: | 2-ethyl-7-methoxy-naphthalene, DNA non-template strand, DNA template strand, ... | 著者 | Malvezzi, S, Farnung, L, Aloisi, C, Angelov, T, Cramer, P, Sturla, S.J. | 登録日 | 2017-08-19 | 公開日 | 2017-11-01 | 最終更新日 | 2019-07-10 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Mechanism of RNA polymerase II stalling by DNA alkylation. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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7UND
| Pol II-DSIF-SPT6-PAF1c-TFIIS-nucleosome complex (stalled at +38) | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB7, ... | 著者 | Filipovski, M, Vos, S.M, Farnung, L. | 登録日 | 2022-04-10 | 公開日 | 2022-10-19 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis of nucleosome retention during transcription elongation. Science, 376, 2022
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7UNC
| Pol II-DSIF-SPT6-PAF1c-TFIIS complex with rewrapped nucleosome | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB7, ... | 著者 | Filipovski, M, Vos, S.M, Farnung, L. | 登録日 | 2022-04-10 | 公開日 | 2022-10-19 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis of nucleosome retention during transcription elongation. Science, 376, 2022
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9GD0
| Structure of a hexasome-nucleosome complex with a dyad-to-dyad distance of 103 bp. | 分子名称: | DNA (250-MER), Histone H2A type 1, Histone H2B 1.1, ... | 著者 | Engeholm, M, Roske, J.J, Oberbeckmann, E, Dienemann, C, Lidschreiber, M, Cramer, P, Farnung, L. | 登録日 | 2024-08-04 | 公開日 | 2024-09-18 | 最終更新日 | 2024-10-02 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT. Mol.Cell, 84, 2024
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9GD3
| Structure of a mononucleosome bound by one copy of Chd1 with the DBD on the exit-side DNA. | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Chromo domain-containing protein 1, ... | 著者 | Engeholm, M, Roske, J.J, Oberbeckmann, E, Dienemann, C, Lidschreiber, M, Cramer, P, Farnung, L. | 登録日 | 2024-08-04 | 公開日 | 2024-09-18 | 最終更新日 | 2024-10-02 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT. Mol.Cell, 84, 2024
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9GD1
| Structure of Chd1 bound to a hexasome-nucleosome complex with a dyad-to-dyad distance of 103 bp. | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Chromo domain-containing protein 1, ... | 著者 | Engeholm, M, Roske, J.J, Oberbeckmann, E, Dienemann, C, Lidschreiber, M, Cramer, P, Farnung, L. | 登録日 | 2024-08-04 | 公開日 | 2024-09-18 | 最終更新日 | 2024-10-02 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT. Mol.Cell, 84, 2024
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9GD2
| Structure of Chd1 bound to a dinucleosome with a dyad-to-dyad distance of 103 bp. | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Chromo domain-containing protein 1, ... | 著者 | Engeholm, M, Roske, J.J, Oberbeckmann, E, Dienemann, C, Lidschreiber, M, Cramer, P, Farnung, L. | 登録日 | 2024-08-04 | 公開日 | 2024-09-18 | 最終更新日 | 2024-10-02 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT. Mol.Cell, 84, 2024
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7B3D
| Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with AMP at position -4 (structure 3) | 分子名称: | RNA (5'-R(P*CP*UP*AP*CP*GP*CP*AP*GP*UP*G)-3'), RNA (5'-R(P*UP*GP*CP*AP*CP*UP*GP*CP*GP*UP*AP*G)-3'), SARS-CoV-2 RNA-dependent RNA polymerase nsp12, ... | 著者 | Kokic, G, Hillen, H.S, Tegunov, D, Dienemann, C, Seitz, F, Schmitzova, J, Farnung, L, Siewert, A, Hoebartner, C, Cramer, P. | 登録日 | 2020-11-30 | 公開日 | 2020-12-23 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nat Commun, 12, 2021
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7B3B
| Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with Remdesivir at position -3 (structure 1) | 分子名称: | DNA/RNA (5'-R(P*CP*UP*AP*CP*GP*CP*G)-D(P*(RMP))-R(P*UP*G)-3'), Non-structural protein 7, Non-structural protein 8, ... | 著者 | Kokic, G, Hillen, H.S, Tegunov, D, Dienemann, C, Seitz, F, Schmitzova, J, Farnung, L, Siewert, A, Hoebartner, C, Cramer, P. | 登録日 | 2020-11-30 | 公開日 | 2020-12-23 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nat Commun, 12, 2021
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7B3C
| Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with Remdesivir at position -4 (structure 2) | 分子名称: | DNA/RNA (5'-R(P*CP*UP*AP*CP*GP*CP*A)-D(P*(RMP))-R(P*GP*UP*G)-3'), Non-structural protein 7, Non-structural protein 8, ... | 著者 | Kokic, G, Hillen, H.S, Tegunov, D, Dienemann, C, Seitz, F, Schmitzova, J, Farnung, L, Siewert, A, Hoebartner, C, Cramer, P. | 登録日 | 2020-11-30 | 公開日 | 2020-12-23 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nat Commun, 12, 2021
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6EXV
| Structure of mammalian RNA polymerase II elongation complex inhibited by Alpha-amanitin | 分子名称: | AMATOXIN, DNA (25-MER), DNA (36-MER), ... | 著者 | Liu, X, Farnung, L, Wigge, C, Cramer, P. | 登録日 | 2017-11-09 | 公開日 | 2018-03-21 | 最終更新日 | 2019-12-11 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Cryo-EM structure of a mammalian RNA polymerase II elongation complex inhibited by alpha-amanitin. J. Biol. Chem., 293, 2018
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6TED
| Structure of complete, activated transcription complex Pol II-DSIF-PAF-SPT6 uncovers allosteric elongation activation by RTF1 | 分子名称: | DNA (37-MER), DNA-directed RNA polymerase II subunit RPB9, DNA-directed RNA polymerase subunit, ... | 著者 | Vos, S.M, Farnung, L, Cramer, P. | 登録日 | 2019-11-11 | 公開日 | 2020-07-22 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure of complete Pol II-DSIF-PAF-SPT6 transcription complex reveals RTF1 allosteric activation. Nat.Struct.Mol.Biol., 27, 2020
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6GME
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