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4IDP
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BU of 4idp by Molmil
human atlastin-1 1-446, N440T, GppNHp
分子名称: Atlastin-1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
著者Byrnes, L.J, Singh, A, Szeto, K, Benvin, N.M, O'Donnell, J.P, Zipfel, W.R, Sondermann, H.
登録日2012-12-12
公開日2013-01-09
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.587 Å)
主引用文献Structural basis for conformational switching and GTP loading of the large G protein atlastin.
Embo J., 32, 2013
4IDQ
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BU of 4idq by Molmil
human atlastin-1 1-446, N440T, GDPAlF4-
分子名称: Atlastin-1, GUANOSINE-5'-DIPHOSPHATE, HEXAETHYLENE GLYCOL, ...
著者Byrnes, L.J, Singh, A, Szeto, K, Benvin, N.M, O'Donnell, J.P, Zipfel, W.R, Sondermann, H.
登録日2012-12-12
公開日2013-01-09
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.295 Å)
主引用文献Structural basis for conformational switching and GTP loading of the large G protein atlastin.
Embo J., 32, 2013
4IDN
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BU of 4idn by Molmil
Human atlastin-1 1-446, C-his6, GppNHp
分子名称: Atlastin-1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
著者Byrnes, L.J, Singh, A, Szeto, K, Benvin, N.M, O'Donnell, J.P, Zipfel, W.R, Sondermann, H.
登録日2012-12-12
公開日2013-01-09
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.252 Å)
主引用文献Structural basis for conformational switching and GTP loading of the large G protein atlastin.
Embo J., 32, 2013
4IDO
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BU of 4ido by Molmil
human atlastin-1 1-446, C-his6, GDPAlF4-
分子名称: Atlastin-1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Byrnes, L.J, Singh, A, Szeto, K, Benvin, N.M, O'Donnell, J.P, Zipfel, W.R, Sondermann, H.
登録日2012-12-12
公開日2013-01-09
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.091 Å)
主引用文献Structural basis for conformational switching and GTP loading of the large G protein atlastin.
Embo J., 32, 2013
3Q5D
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BU of 3q5d by Molmil
crystal structure of human Atlastin-1 (residues 1-447) bound to GDP, crystal form 1
分子名称: Atlastin-1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
著者Byrnes, L.J, Sondermann, H.
登録日2010-12-28
公開日2011-01-19
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.699 Å)
主引用文献Structural basis for the nucleotide-dependent dimerization of the large G protein atlastin-1/SPG3A.
Proc.Natl.Acad.Sci.USA, 108, 2011
3Q5E
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BU of 3q5e by Molmil
crystal structure of human Atlastin-1 (residues 1-447) bound to GDP, crystal form 2
分子名称: Atlastin-1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
著者Byrnes, L.J, Sondermann, H.
登録日2010-12-28
公開日2011-01-19
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.013 Å)
主引用文献Structural basis for the nucleotide-dependent dimerization of the large G protein atlastin-1/SPG3A.
Proc.Natl.Acad.Sci.USA, 108, 2011
4WZ6
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BU of 4wz6 by Molmil
Human CFTR aa389-678 (NBD1), deltaF508 with three solubilizing mutations, bound ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION
著者Byrnes, L.J, Hall, J.
登録日2014-11-18
公開日2015-11-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Binding screen for cystic fibrosis transmembrane conductance regulator correctors finds new chemical matter and yields insights into cystic fibrosis therapeutic strategy.
Protein Sci., 25, 2016
5VDU
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BU of 5vdu by Molmil
Human cyclic GMP-AMP synthase (cGAS) in complex with Compound F2
分子名称: 2-(pyridin-2-yl)pyrimidine, Cyclic GMP-AMP synthase, ZINC ION
著者Byrnes, L.J, Hall, J.D.
登録日2017-04-03
公開日2017-09-27
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.729 Å)
主引用文献The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.
Protein Sci., 26, 2017
5VDV
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BU of 5vdv by Molmil
Human cyclic GMP-AMP synthase (cGAS) in complex with Compound F3
分子名称: Cyclic GMP-AMP synthase, SULFATE ION, ZINC ION, ...
著者Byrnes, L.J, Hall, J.D.
登録日2017-04-03
公開日2017-09-27
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.998 Å)
主引用文献The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.
Protein Sci., 26, 2017
5VDT
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BU of 5vdt by Molmil
Human cyclic GMP-AMP synthase (cGAS) in complex with 3',3'-cGAMP
分子名称: 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, Cyclic GMP-AMP synthase, ZINC ION
著者Byrnes, L.J, Hall, J.D.
登録日2017-04-03
公開日2017-09-27
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.576 Å)
主引用文献The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.
Protein Sci., 26, 2017
5VDW
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BU of 5vdw by Molmil
Human cyclic GMP-AMP synthase (cGAS) in complex with Compound F1
分子名称: Cyclic GMP-AMP synthase, ZINC ION, [2-(1,3-thiazol-4-yl)-1H-benzimidazol-1-yl]acetic acid
著者Byrnes, L.J, Hall, J.D.
登録日2017-04-03
公開日2017-09-27
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.711 Å)
主引用文献The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.
Protein Sci., 26, 2017
5VDQ
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BU of 5vdq by Molmil
Human cyclic GMP-AMP synthase (cGAS) in complex with 2',5'-GpAp
分子名称: 2',5'-GpAp, Cyclic GMP-AMP synthase, ZINC ION
著者Byrnes, L.J, Hall, J.D.
登録日2017-04-03
公開日2017-09-27
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.246 Å)
主引用文献The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.
Protein Sci., 26, 2017
5VDR
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BU of 5vdr by Molmil
Human cyclic GMP-AMP synthase (cGAS) in complex with 3',3'-cdIMP
分子名称: 3',3'-cdIMP, Cyclic GMP-AMP synthase, ZINC ION
著者Byrnes, L.J, Hall, J.D.
登録日2017-04-03
公開日2017-09-27
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.042 Å)
主引用文献The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.
Protein Sci., 26, 2017
5VDP
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BU of 5vdp by Molmil
Human cyclic GMP-AMP synthase (cGAS) in complex with 2',3'-cGAMP
分子名称: Cyclic GMP-AMP synthase, SULFATE ION, ZINC ION, ...
著者Byrnes, L.J, Hall, J.D.
登録日2017-04-03
公開日2017-09-27
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.
Protein Sci., 26, 2017
5VDO
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BU of 5vdo by Molmil
Human cyclic GMP-AMP synthase (cGAS) in complex with 2',2'-cGAMP
分子名称: 2-amino-9-[(1R,3R,6R,8R,9R,11S,14R,16R,17R,18R)-16-(6-amino-9H-purin-9-yl)-3,11,17,18-tetrahydroxy-3,11-dioxido-2,4,7,10,12,15-hexaoxa-3,11-diphosphatricyclo[12.2.1.1~6,9~]octadec-8-yl]-1,9-dihydro-6H-purin-6-one, Cyclic GMP-AMP synthase, ZINC ION
著者Byrnes, L.J, Hall, J.D.
登録日2017-04-03
公開日2017-09-27
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.218 Å)
主引用文献The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.
Protein Sci., 26, 2017
5VDS
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BU of 5vds by Molmil
Human cyclic GMP-AMP synthase (cGAS) in complex with 3',3'-cdUMP
分子名称: 3',3'-cdUMP, Cyclic GMP-AMP synthase, ZINC ION
著者Byrnes, L.J, Hall, J.D.
登録日2017-04-03
公開日2017-09-27
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.766 Å)
主引用文献The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.
Protein Sci., 26, 2017
8DKB
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BU of 8dkb by Molmil
Crystal Structure of human YEATS4 in complex with Pfizer small molecule compound 3b
分子名称: N-ethyl-1-{(3S,4S)-1-[(1-hydroxycyclohexyl)methyl]-3-methylpiperidin-4-yl}-2-methyl-1H-benzimidazole-5-carboxamide, YEATS domain-containing protein 4
著者Dias, J.M, Byrnes, L.J, Varghese, A.H.
登録日2022-07-05
公開日2023-01-11
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.58 Å)
主引用文献Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.
J.Med.Chem., 66, 2023
6XJO
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BU of 6xjo by Molmil
Human atlastin-3 (residues 1-334) bound to GDP-Mg2+ exhibits an ordered amino terminus
分子名称: Atlastin-3, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
著者O'Donnell, J.P, Sondermann, H.
登録日2020-06-24
公開日2021-06-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The hypervariable region of atlastin-1 is a site for intrinsic and extrinsic regulation.
J.Cell Biol., 220, 2021
6XJN
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BU of 6xjn by Molmil
Human atlastin-1 (residues 1-439) bound to GDP-Mg2+ exhibits an ordered amino terminus
分子名称: Atlastin-1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
著者O'Donnell, J.P, Sondermann, H.
登録日2020-06-24
公開日2021-06-30
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The hypervariable region of atlastin-1 is a site for intrinsic and extrinsic regulation.
J.Cell Biol., 220, 2021
6B9E
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BU of 6b9e by Molmil
Human ATL1 mutant - R77A / F151S bound to GDP
分子名称: Atlastin-1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者O'Donnell, J.P, Sondermann, H.
登録日2017-10-10
公開日2017-12-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献A hereditary spastic paraplegia-associated atlastin variant exhibits defective allosteric coupling in the catalytic core.
J. Biol. Chem., 293, 2018
6B9G
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BU of 6b9g by Molmil
human ATL1 GTPase domain bound to GDP
分子名称: Atlastin-1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
著者O'Donnell, J.P, Sondermann, H.
登録日2017-10-10
公開日2017-12-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献A hereditary spastic paraplegia-associated atlastin variant exhibits defective allosteric coupling in the catalytic core.
J. Biol. Chem., 293, 2018
6B9D
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BU of 6b9d by Molmil
Human ATL1 mutant - R77A bound to GDP
分子名称: Atlastin-1, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ...
著者O'Donnell, J.P, Sondermann, H.
登録日2017-10-10
公開日2017-12-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献A hereditary spastic paraplegia-associated atlastin variant exhibits defective allosteric coupling in the catalytic core.
J. Biol. Chem., 293, 2018
6B9F
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BU of 6b9f by Molmil
Human ATL1 mutant - F151S bound to GDPAlF4-
分子名称: Atlastin-1, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ...
著者O'Donnell, J.P, Sondermann, H.
登録日2017-10-10
公開日2017-12-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A hereditary spastic paraplegia-associated atlastin variant exhibits defective allosteric coupling in the catalytic core.
J. Biol. Chem., 293, 2018
3RWA
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BU of 3rwa by Molmil
Crystal structure of circular-permutated mKate
分子名称: Fluorescent protein FP480
著者Wang, Q, Byrnes, L, Sondermann, H.
登録日2011-05-08
公開日2011-06-15
最終更新日2019-07-17
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Circular permutation of red fluorescent proteins.
Plos One, 6, 2011
3SVR
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BU of 3svr by Molmil
Crystal structure of mkate mutant S158A/S143C at pH 7.5
分子名称: mkate S158A/S143C
著者Wang, Q, Byrnes, L, Sondermann, H.
登録日2011-07-12
公開日2011-09-14
実験手法X-RAY DIFFRACTION (1.907 Å)
主引用文献Molecular Mechanism of a Green-Shifted, pH-Dependent Red Fluorescent Protein mKate Variant.
Plos One, 6, 2011

 

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