5VDT
Human cyclic GMP-AMP synthase (cGAS) in complex with 3',3'-cGAMP
Summary for 5VDT
Entry DOI | 10.2210/pdb5vdt/pdb |
Related | 5VDO 5VDP 5VDQ 5VDR 5VDS 5VDU 5VDV 5VDW |
Descriptor | Cyclic GMP-AMP synthase, ZINC ION, 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, ... (4 entities in total) |
Functional Keywords | transferase, sting, cgamp |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytosol . Note=(Microbial infection) Upon infection with virulent M: Q8N884 |
Total number of polymer chains | 2 |
Total formula weight | 86551.84 |
Authors | Byrnes, L.J.,Hall, J.D. (deposition date: 2017-04-03, release date: 2017-09-27, Last modification date: 2023-10-04) |
Primary citation | Hall, J.,Ralph, E.C.,Shanker, S.,Wang, H.,Byrnes, L.J.,Horst, R.,Wong, J.,Brault, A.,Dumlao, D.,Smith, J.F.,Dakin, L.A.,Schmitt, D.C.,Trujillo, J.,Vincent, F.,Griffor, M.,Aulabaugh, A.E. The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition. Protein Sci., 26:2367-2380, 2017 Cited by PubMed: 28940468DOI: 10.1002/pro.3304 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.576 Å) |
Structure validation
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