5VDT
Human cyclic GMP-AMP synthase (cGAS) in complex with 3',3'-cGAMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cyclic GMP-AMP synthase | polymer | 363 | 42536.1 | 2 | UniProt (Q8N884) Pfam (PF03281) Pfam (PF20266) | Homo sapiens (Human) | h-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1 |
| 2 | C, E (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, F (A, B) | 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one | non-polymer | 674.4 | 2 | Chemie (4BW) PubChem (135518383) PubChem (136969326) PubChem (137222342) PubChem (146666430) PubChem (146721591) PubChem (163926673) PubChem (164708339) PubChem (170530654) PubChem (135471108) PubChem (135566855) PubChem (137014984) PubChem (138107821) PubChem (146721594) PubChem (167377552) PubChem (168281482) PubChem (170530664) PubChem (170997023) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 146 | Chemie (HOH) |
Sequence modifications
A, B: 161 - 522 (UniProt: Q8N884)
| PDB | External Database | Details |
|---|---|---|
| Met 160 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 85072.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1479.6 | |
| All* | Total formula weight | 86551.8 |
