5VDO

Human cyclic GMP-AMP synthase (cGAS) in complex with 2',2'-cGAMP

Summary for 5VDO

• Entry DOI: 10.2210/pdb5vdo/pdb
• Related: 5VDP 5VDQ 5VDR 5VDS 5VDT 5VDU 5VDV 5VDW
• Descriptor: Cyclic GMP-AMP synthase, ZINC ION, 2-amino-9-[(1R,3R,6R,8R,9R,11S,14R,16R,17R,18R)-16-(6-amino-9H-purin-9-yl)-3,11,17,18-tetrahydroxy-3,11-dioxido-2,4,7,10,12,15-hexaoxa-3,11-diphosphatricyclo[12.2.1.1~6,9~]octadec-8-yl]-1,9-dihydro-6H-purin-6-one, ... (4 entities in total)
• Functional Keywords: transferase, sting, cgamp
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm, cytosol . Note=(Microbial infection) Upon infection with virulent M: Q8N884
• Total number of polymer chains: 2
• Total formula weight: 86551.84

Authors

Byrnes, L.J.,Hall, J.D. (deposition date: 2017-04-03, release date: 2017-09-27, Last modification date: 2023-10-04)

• Primary citation: Hall, J.,Ralph, E.C.,Shanker, S.,Wang, H.,Byrnes, L.J.,Horst, R.,Wong, J.,Brault, A.,Dumlao, D.,Smith, J.F.,Dakin, L.A.,Schmitt, D.C.,Trujillo, J.,Vincent, F.,Griffor, M.,Aulabaugh, A.E.; The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.; Protein Sci., 26:2367-2380, 2017; PubMed: 28940468; DOI: 10.1002/pro.3304

Experimental method

X-RAY DIFFRACTION (3.218 Å)