4WZ6
Human CFTR aa389-678 (NBD1), deltaF508 with three solubilizing mutations, bound ATP
Summary for 4WZ6
Entry DOI | 10.2210/pdb4wz6/pdb |
Descriptor | Cystic fibrosis transmembrane conductance regulator, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | atpase, hydrolase, atp/adp binding, atp binding protein |
Biological source | Homo sapiens (Human) |
Cellular location | Apical cell membrane ; Multi-pass membrane protein {ECO:0000269|Ref: P13569 |
Total number of polymer chains | 1 |
Total formula weight | 32915.24 |
Authors | Byrnes, L.J.,Hall, J. (deposition date: 2014-11-18, release date: 2015-11-11, Last modification date: 2023-09-27) |
Primary citation | Hall, J.D.,Wang, H.,Byrnes, L.J.,Shanker, S.,Wang, K.,Efremov, I.V.,Chong, P.A.,Forman-Kay, J.D.,Aulabaugh, A.E. Binding screen for cystic fibrosis transmembrane conductance regulator correctors finds new chemical matter and yields insights into cystic fibrosis therapeutic strategy. Protein Sci., 25:360-373, 2016 Cited by PubMed: 26444971DOI: 10.1002/pro.2821 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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