4WZ6
Human CFTR aa389-678 (NBD1), deltaF508 with three solubilizing mutations, bound ATP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Cystic fibrosis transmembrane conductance regulator | polymer | 290 | 32383.8 | 1 | UniProt (P13569) Pfam (PF00005) In PDB | Homo sapiens (Human) | CFTR,ATP-binding cassette sub-family C member 7,Channel conductance-controlling ATPase,cAMP-dependent chloride channel |
| 2 | A | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
| 3 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | water | water | 18.0 | 48 | Chemie (HOH) |
Sequence modifications
A: 389 - 677 (UniProt: P13569)
| PDB | External Database | Details |
|---|---|---|
| Ser 388 | - | expression tag |
| Ser 429 | Phe 429 | engineered mutation |
| Met 470 | Val 470 | variant |
| Asn 494 | Phe 494 | engineered mutation |
| - | Phe 508 | deletion |
| Arg 636 | Gln 637 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32383.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 531.5 | |
| All* | Total formula weight | 32915.2 |
