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5VDW

Human cyclic GMP-AMP synthase (cGAS) in complex with Compound F1

Summary for 5VDW
Entry DOI10.2210/pdb5vdw/pdb
Related5VDO 5VDP 5VDQ 5VDR 5VDS 5VDT 5VDU 5VDV
DescriptorCyclic GMP-AMP synthase, ZINC ION, [2-(1,3-thiazol-4-yl)-1H-benzimidazol-1-yl]acetic acid, ... (4 entities in total)
Functional Keywordstransferase, sting, cgamp
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm, cytosol . Note=(Microbial infection) Upon infection with virulent M: Q8N884
Total number of polymer chains2
Total formula weight85721.59
Authors
Byrnes, L.J.,Hall, J.D. (deposition date: 2017-04-03, release date: 2017-09-27, Last modification date: 2023-10-04)
Primary citationHall, J.,Ralph, E.C.,Shanker, S.,Wang, H.,Byrnes, L.J.,Horst, R.,Wong, J.,Brault, A.,Dumlao, D.,Smith, J.F.,Dakin, L.A.,Schmitt, D.C.,Trujillo, J.,Vincent, F.,Griffor, M.,Aulabaugh, A.E.
The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.
Protein Sci., 26:2367-2380, 2017
Cited by
PubMed: 28940468
DOI: 10.1002/pro.3304
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.711 Å)
Structure validation

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