1T8I
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![BU of 1t8i by Molmil](/molmil-images/mine/1t8i) | Human DNA Topoisomerase I (70 Kda) In Complex With The Poison Camptothecin and Covalent Complex With A 22 Base Pair DNA Duplex | 分子名称: | 4-ETHYL-4-HYDROXY-1,12-DIHYDRO-4H-2-OXA-6,12A-DIAZA-DIBENZO[B,H]FLUORENE-3,13-DIONE, 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', ... | 著者 | Staker, B.L, Feese, M.D, Cushman, M, Pommier, Y, Zembower, D, Stewart, L, Burgin, A.B. | 登録日 | 2004-05-12 | 公開日 | 2005-05-31 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex J.Med.Chem., 48, 2005
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3L4J
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![BU of 3l4j by Molmil](/molmil-images/mine/3l4j) | Topoisomerase II-DNA cleavage complex, apo | 分子名称: | 3'-THIO-THYMIDINE-5'-PHOSPHATE, DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*CP*GP*TP*CP*AP*TP*CP*C)-3'), DNA (5'-D(*CP*GP*CP*GP*GP*TP*AP*GP*CP*AP*GP*TP*AP*GP*G)-3'), ... | 著者 | Schmidt, B.H, Burgin, A.B, Deweese, J.E, Osheroff, N, Berger, J.M. | 登録日 | 2009-12-20 | 公開日 | 2010-05-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases. Nature, 465, 2010
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3L4K
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![BU of 3l4k by Molmil](/molmil-images/mine/3l4k) | Topoisomerase II-DNA cleavage complex, metal-bound | 分子名称: | 3'-THIO-THYMIDINE-5'-PHOSPHATE, DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*CP*GP*TP*CP*AP*TP*CP*C)-3'), DNA (5'-D(*CP*GP*CP*GP*GP*TP*AP*GP*CP*AP*GP*TP*AP*GP*G)-3'), ... | 著者 | Schmidt, B.H, Burgin, A.B, Deweese, J.E, Osheroff, N, Berger, J.M. | 登録日 | 2009-12-20 | 公開日 | 2010-05-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | 主引用文献 | A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases. Nature, 465, 2010
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1RRJ
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![BU of 1rrj by Molmil](/molmil-images/mine/1rrj) | Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I | 分子名称: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, 2-(1-DIMETHYLAMINOMETHYL-2-HYDROXY-8-HYDROXYMETHYL-9-OXO-9,11-DIHYDRO-INDOLIZINO[1,2-B]QUINOLIN-7-YL)-2-HYDROXY-BUTYRIC ACID, 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T*GP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', ... | 著者 | Chrencik, J.E, Staker, B.L, Burgin, A.B, Stewart, L, Redinbo, M.R. | 登録日 | 2003-12-08 | 公開日 | 2004-07-06 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Mechanisms of camptothecin resistance by human topoisomerase I mutations J.Mol.Biol., 339, 2004
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1SEU
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![BU of 1seu by Molmil](/molmil-images/mine/1seu) | Human DNA Topoisomerase I (70 Kda) In Complex With The Indolocarbazole SA315F and Covalent Complex With A 22 Base Pair DNA Duplex | 分子名称: | 2,10-DIHYDROXY-12-(BETA-D-GLUCOPYRANOSYL)-6,7,12,13-TETRAHYDROINDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOLE-5,7-DIONE, 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', ... | 著者 | Staker, B.L, Feese, M.D, Cushman, M, Pommier, Y, Zembower, D, Stewart, L, Burgin, A.B. | 登録日 | 2004-02-18 | 公開日 | 2005-04-19 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex J.Med.Chem., 48, 2005
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1SC7
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![BU of 1sc7 by Molmil](/molmil-images/mine/1sc7) | Human DNA Topoisomerase I (70 Kda) In Complex With The Indenoisoquinoline MJ-II-38 and Covalent Complex With A 22 Base Pair DNA Duplex | 分子名称: | 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE, 5'-D(*(TGP)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', ... | 著者 | Staker, B.L, Feese, M.D, Cushman, M, Pommier, Y, Zembower, D, Stewart, L, Burgin, A.B. | 登録日 | 2004-02-11 | 公開日 | 2005-04-19 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex J.Med.Chem., 48, 2005
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1RR8
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![BU of 1rr8 by Molmil](/molmil-images/mine/1rr8) | Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I | 分子名称: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, 2-(1-DIMETHYLAMINOMETHYL-2-HYDROXY-8-HYDROXYMETHYL-9-OXO-9,11-DIHYDRO-INDOLIZINO[1,2-B]QUINOLIN-7-YL)-2-HYDROXY-BUTYRIC ACID, 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T*GP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', ... | 著者 | Chrencik, J.E, Staker, B.L, Burgin, A.B, Stewart, L, Redinbo, M.R. | 登録日 | 2003-12-08 | 公開日 | 2004-07-06 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Mechanisms of camptothecin resistance by human topoisomerase I mutations J.Mol.Biol., 339, 2004
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1NH3
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![BU of 1nh3 by Molmil](/molmil-images/mine/1nh3) | Human Topoisomerase I Ara-C Complex | 分子名称: | 5'-D(*(GNG)P*GP*AP*AP*AP*AP*AP*UP*UP*UP*UP*T)-3', 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*UP*(UBB))-3', 5'-D(*AP*AP*AP*AP*AP*TP*UP*UP*UP*UP*CP*(CAR)P*AP*AP*GP*UP*CP*UP*UP*UP*UP*T)-3', ... | 著者 | Chrencik, J.E, Burgin, A.B, Pommier, Y, Stewart, L, Redinbo, M.R. | 登録日 | 2002-12-18 | 公開日 | 2003-03-04 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural Impact of the Leukemia Drug 1-beta-D-Arabinofuranosylcytosine (Ara-C) on the Covalent Human Topoisomerase I-DNA Complex J.Biol.Chem., 278, 2003
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3IAD
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![BU of 3iad by Molmil](/molmil-images/mine/3iad) | |
3G4I
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![BU of 3g4i by Molmil](/molmil-images/mine/3g4i) | Crystal structure of human phosphodiesterase 4d with d155871 | 分子名称: | 1-(3-nitrophenyl)-3-(pyridin-4-ylmethyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione, ETHANOL, MAGNESIUM ION, ... | 著者 | Staker, B.L. | 登録日 | 2009-02-03 | 公開日 | 2010-01-19 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety. Nat.Biotechnol., 28, 2010
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3G4L
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![BU of 3g4l by Molmil](/molmil-images/mine/3g4l) | Crystal structure of human phosphodiesterase 4d with roflumilast | 分子名称: | 1,2-ETHANEDIOL, 3-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-(DIFLUOROMETHOXY)BENZAMIDE, MAGNESIUM ION, ... | 著者 | Staker, B.L. | 登録日 | 2009-02-03 | 公開日 | 2010-01-19 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety. Nat.Biotechnol., 28, 2010
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3G58
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![BU of 3g58 by Molmil](/molmil-images/mine/3g58) | |
3G4K
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![BU of 3g4k by Molmil](/molmil-images/mine/3g4k) | |
3G45
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![BU of 3g45 by Molmil](/molmil-images/mine/3g45) | |
3G4G
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![BU of 3g4g by Molmil](/molmil-images/mine/3g4g) | |
3UWA
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![BU of 3uwa by Molmil](/molmil-images/mine/3uwa) | Crystal structure of a probable peptide deformylase from synechococcus phage S-SSM7 | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, RIIA-RIIB membrane-associated protein, ZINC ION | 著者 | Lorimer, D, Abendroth, J, Edwards, T.E, Burgin, A, Segall, A, Rohwer, F. | 登録日 | 2011-12-01 | 公開日 | 2013-01-09 | 最終更新日 | 2013-06-19 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structure and function of a cyanophage-encoded peptide deformylase. ISME J, 7, 2013
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3UWB
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![BU of 3uwb by Molmil](/molmil-images/mine/3uwb) | Crystal structure of a probable peptide deformylase from strucynechococcus phage S-SSM7 in complex with actinonin | 分子名称: | 1,2-ETHANEDIOL, ACTINONIN, CHLORIDE ION, ... | 著者 | Lorimer, D, Abendroth, J, Edwards, T.E, Burgin, A, Segall, A, Rohwer, F. | 登録日 | 2011-12-01 | 公開日 | 2013-01-09 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure and function of a cyanophage-encoded peptide deformylase. ISME J, 7, 2013
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4DR9
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![BU of 4dr9 by Molmil](/molmil-images/mine/4dr9) | Crystal structure of a peptide deformylase from synechococcus elongatus in complex with actinonin | 分子名称: | ACTINONIN, BROMIDE ION, Peptide deformylase, ... | 著者 | Lorimer, D, Abendroth, J, Craig, T, Burgin, A, Segall, A, Rohwler, F. | 登録日 | 2012-02-17 | 公開日 | 2013-01-16 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure and function of a cyanophage-encoded peptide deformylase. ISME J, 7, 2013
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4ZBN
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![BU of 4zbn by Molmil](/molmil-images/mine/4zbn) | |
4NW7
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![BU of 4nw7 by Molmil](/molmil-images/mine/4nw7) | PDE4 catalytic domain | 分子名称: | (4-{[4-(3-chlorophenyl)-6-cyclopropyl-1,3,5-triazin-2-yl]amino}phenyl)acetic acid, 1,2-ETHANEDIOL, MAGNESIUM ION, ... | 著者 | Fox III, D, Edwards, T.E. | 登録日 | 2013-12-05 | 公開日 | 2014-10-15 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Discovery of triazines as selective PDE4B versus PDE4D inhibitors. Bioorg.Med.Chem.Lett., 24, 2014
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4MYQ
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4WMW
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![BU of 4wmw by Molmil](/molmil-images/mine/4wmw) | |
4WMS
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![BU of 4wms by Molmil](/molmil-images/mine/4wms) | STRUCTURE OF APO MBP-MCL1 AT 1.9A | 分子名称: | 1,2-ETHANEDIOL, FORMIC ACID, MAGNESIUM ION, ... | 著者 | Clifton, M.C, Dranow, D.M. | 登録日 | 2014-10-09 | 公開日 | 2015-05-06 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1. Plos One, 10, 2015
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4WMR
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![BU of 4wmr by Molmil](/molmil-images/mine/4wmr) | STRUCTURE OF MCL1 BOUND TO BRD inhibitor ligand 1 AT 1.7A | 分子名称: | 7-[2-(1H-imidazol-1-yl)-4-methylpyridin-3-yl]-3-[3-(naphthalen-1-yloxy)propyl]-1-[2-oxo-2-(piperazin-1-yl)ethyl]-1H-indole-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1, PYROPHOSPHATE 2-, ... | 著者 | CLIFTON, M.C, EDWARDS, T.E. | 登録日 | 2014-10-09 | 公開日 | 2015-05-06 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1. Plos One, 10, 2015
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4WMX
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![BU of 4wmx by Molmil](/molmil-images/mine/4wmx) | |