3G4G
Crystal structure of human phosphodiesterase 4d with regulatory domain and d155871
Summary for 3G4G
Entry DOI | 10.2210/pdb3g4g/pdb |
Related | 3G45 3G4I 3G4K 3G4L 3G58 3GPZ |
Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | phosphodiesterase, pde4d, ucr2, alternative splicing, camp, cytoplasm, cytoskeleton, hydrolase, membrane, metal-binding, phosphoprotein |
Biological source | Homo sapiens (human) More |
Cellular location | Apical cell membrane : Q08499 |
Total number of polymer chains | 4 |
Total formula weight | 195503.72 |
Authors | Staker, B.L. (deposition date: 2009-02-03, release date: 2010-01-19, Last modification date: 2024-02-21) |
Primary citation | Burgin, A.B.,Magnusson, O.T.,Singh, J.,Witte, P.,Staker, B.L.,Bjornsson, J.M.,Thorsteinsdottir, M.,Hrafnsdottir, S.,Hagen, T.,Kiselyov, A.S.,Stewart, L.J.,Gurney, M.E. Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety. Nat.Biotechnol., 28:63-70, 2010 Cited by PubMed: 20037581DOI: 10.1038/nbt.1598 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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