3G4G
Crystal structure of human phosphodiesterase 4d with regulatory domain and d155871
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | polymer | 421 | 48370.8 | 4 | UniProt (Q08499) Pfam (PF18100) Pfam (PF00233) In PDB | Homo sapiens (human) | DPDE3, PDE43 |
2 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
3 | A, B, C, D | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
4 | A, B, C, D | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
5 | A, B, C, D | 1-(3-nitrophenyl)-3-(pyridin-4-ylmethyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione | non-polymer | 375.3 | 4 | Chemie (D71) | |||
6 | water | water | 18.0 | 167 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 163 - 214 (UniProt: Q08499)
A, B, C, D: 224 - 578 (UniProt: Q08499)
PDB | External Database | Details |
---|---|---|
Met 162 | - | expression tag |
Ala 579 | - | expression tag |
His 580 | - | expression tag |
His 581 | - | expression tag |
His 582 | - | expression tag |
His 583 | - | expression tag |
His 584 | - | expression tag |
His 585 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Lys 215 | - | linker |
Val 216 | - | linker |
Thr 217 | - | linker |
Ala 218 | - | linker |
Glu 219 | - | linker |
Glu 220 | - | linker |
Ala 221 | - | linker |
Pro 222 | - | linker |
Gln 223 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 193483.2 | |
Non-Polymers* | Number of molecules | 16 |
Total formula weight | 2020.5 | |
All* | Total formula weight | 195503.7 |