3G4G

Crystal structure of human phosphodiesterase 4d with regulatory domain and d155871

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity
B	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
B	0007165	biological_process	signal transduction
B	0008081	molecular_function	phosphoric diester hydrolase activity
C	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
C	0007165	biological_process	signal transduction
C	0008081	molecular_function	phosphoric diester hydrolase activity
D	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
D	0007165	biological_process	signal transduction
D	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 801

Chain	Residue
A	HOH50
A	HIS330
A	HIS366
A	ASP367
A	ASP484

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 802

Chain	Residue
A	HOH80
A	ASP367
A	HOH586

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CA A 4

Chain	Residue
A	HIS271

---

site_id	AC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE D71 A 901

Chain	Residue
A	HOH54
A	HOH154
A	PHE196
A	ILE197
A	PHE201
A	TYR325
A	HIS326
A	LEU485
A	ASN487
A	THR499
A	ILE502
A	MET503
A	PHE506
A	SER534
A	GLN535
A	PHE538

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 803

Chain	Residue
B	HOH59
B	HIS330
B	HIS366
B	ASP367
B	ASP484

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 804

Chain	Residue
B	HOH96
B	HOH118
B	ASP367
B	HOH586

---

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE D71 B 902

Chain	Residue
B	HOH82
B	VAL193
B	PHE196
B	ILE197
B	TYR325
B	HIS326
B	LEU485
B	ASN487
B	THR499
B	ILE502
B	PHE506
B	SER534
B	GLN535
B	PHE538

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN C 805

Chain	Residue
C	HOH34
C	HIS330
C	HIS366
C	ASP367
C	ASP484
C	HOH587

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C 806

Chain	Residue
C	HOH72
C	HOH88
C	ASP367
C	HOH587

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA C 2

Chain	Residue
C	HIS271
C	ARG274

---

site_id	BC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE D71 C 903

Chain	Residue
C	HOH31
C	PHE196
C	ILE197
C	TYR325
C	HIS326
C	LEU485
C	ASN487
C	THR499
C	ILE502
C	PHE506
C	MET523
C	SER534
C	GLN535
C	PHE538
C	HOH586

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN D 807

Chain	Residue
D	HOH21
D	HIS330
D	HIS366
D	ASP367
D	ASP484

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D 808

Chain	Residue
D	HOH6
D	HOH67
D	HOH84
D	HOH140
D	ASP367

---

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CA D 3

Chain	Residue
D	HIS271

---

site_id	BC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE D71 D 904

Chain	Residue
D	HOH33
D	VAL193
D	PHE196
D	ILE197
D	TYR325
D	HIS326
D	LEU485
D	ASN487
D	THR499
D	ILE502
D	SER534
D	GLN535
D	PHE538

---

Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF

Chain	Residue	Details
A	HIS366-PHE377

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"Q07343","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14609333","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14609333","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15576036","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17582435","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PW3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14609333","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15576036","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17582435","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PW3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14609333","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PTW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---