3G4G
Crystal structure of human phosphodiesterase 4d with regulatory domain and d155871
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| C | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| C | 0007165 | biological_process | signal transduction |
| C | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| D | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| D | 0007165 | biological_process | signal transduction |
| D | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 801 |
| Chain | Residue |
| A | HOH50 |
| A | HIS330 |
| A | HIS366 |
| A | ASP367 |
| A | ASP484 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 802 |
| Chain | Residue |
| A | HOH80 |
| A | ASP367 |
| A | HOH586 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CA A 4 |
| Chain | Residue |
| A | HIS271 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE D71 A 901 |
| Chain | Residue |
| A | HOH54 |
| A | HOH154 |
| A | PHE196 |
| A | ILE197 |
| A | PHE201 |
| A | TYR325 |
| A | HIS326 |
| A | LEU485 |
| A | ASN487 |
| A | THR499 |
| A | ILE502 |
| A | MET503 |
| A | PHE506 |
| A | SER534 |
| A | GLN535 |
| A | PHE538 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 803 |
| Chain | Residue |
| B | HOH59 |
| B | HIS330 |
| B | HIS366 |
| B | ASP367 |
| B | ASP484 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 804 |
| Chain | Residue |
| B | HOH96 |
| B | HOH118 |
| B | ASP367 |
| B | HOH586 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE D71 B 902 |
| Chain | Residue |
| B | HOH82 |
| B | VAL193 |
| B | PHE196 |
| B | ILE197 |
| B | TYR325 |
| B | HIS326 |
| B | LEU485 |
| B | ASN487 |
| B | THR499 |
| B | ILE502 |
| B | PHE506 |
| B | SER534 |
| B | GLN535 |
| B | PHE538 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN C 805 |
| Chain | Residue |
| C | HOH34 |
| C | HIS330 |
| C | HIS366 |
| C | ASP367 |
| C | ASP484 |
| C | HOH587 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG C 806 |
| Chain | Residue |
| C | HOH72 |
| C | HOH88 |
| C | ASP367 |
| C | HOH587 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA C 2 |
| Chain | Residue |
| C | HIS271 |
| C | ARG274 |
| site_id | BC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE D71 C 903 |
| Chain | Residue |
| C | HOH31 |
| C | PHE196 |
| C | ILE197 |
| C | TYR325 |
| C | HIS326 |
| C | LEU485 |
| C | ASN487 |
| C | THR499 |
| C | ILE502 |
| C | PHE506 |
| C | MET523 |
| C | SER534 |
| C | GLN535 |
| C | PHE538 |
| C | HOH586 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN D 807 |
| Chain | Residue |
| D | HOH21 |
| D | HIS330 |
| D | HIS366 |
| D | ASP367 |
| D | ASP484 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG D 808 |
| Chain | Residue |
| D | HOH6 |
| D | HOH67 |
| D | HOH84 |
| D | HOH140 |
| D | ASP367 |
| site_id | BC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CA D 3 |
| Chain | Residue |
| D | HIS271 |
| site_id | BC6 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE D71 D 904 |
| Chain | Residue |
| D | HOH33 |
| D | VAL193 |
| D | PHE196 |
| D | ILE197 |
| D | TYR325 |
| D | HIS326 |
| D | LEU485 |
| D | ASN487 |
| D | THR499 |
| D | ILE502 |
| D | SER534 |
| D | GLN535 |
| D | PHE538 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF |
| Chain | Residue | Details |
| A | HIS366-PHE377 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q07343 |
| Chain | Residue | Details |
| A | HIS326 | |
| B | HIS326 | |
| C | HIS326 | |
| D | HIS326 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7 |
| Chain | Residue | Details |
| A | HIS326 | |
| D | HIS326 | |
| D | ASN487 | |
| D | GLN535 | |
| A | ASN487 | |
| A | GLN535 | |
| B | HIS326 | |
| B | ASN487 | |
| B | GLN535 | |
| C | HIS326 | |
| C | ASN487 | |
| C | GLN535 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3 |
| Chain | Residue | Details |
| A | HIS330 | |
| B | HIS330 | |
| C | HIS330 | |
| D | HIS330 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 |
| Chain | Residue | Details |
| A | HIS366 | |
| A | ASP484 | |
| B | HIS366 | |
| B | ASP484 | |
| C | HIS366 | |
| C | ASP484 | |
| D | HIS366 | |
| D | ASP484 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW |
| Chain | Residue | Details |
| A | ASP367 | |
| A | PHE538 | |
| B | ASP367 | |
| B | PHE538 | |
| C | ASP367 | |
| C | PHE538 | |
| D | ASP367 | |
| D | PHE538 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| A | SER163 | |
| A | SER165 | |
| B | SER163 | |
| B | SER165 | |
| C | SER163 | |
| C | SER165 | |
| D | SER163 | |
| D | SER165 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER239 | |
| B | SER239 | |
| C | SER239 | |
| D | SER239 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) |
| Chain | Residue | Details |
| A | LYS251 | |
| B | LYS251 | |
| C | LYS251 | |
| D | LYS251 |
