3IAD
Crystal structure of human phosphodiesterase 4D with bound allosteric modulator
Summary for 3IAD
Entry DOI | 10.2210/pdb3iad/pdb |
Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4D, 1-{4-[(2-fluoro-6-methoxy-3'-nitrobiphenyl-3-yl)methyl]phenyl}urea, ZINC ION, ... (6 entities in total) |
Functional Keywords | pde4d, allosteric modulatory, inhibitor, ucr2, alternative splicing, camp, cytoplasm, cytoskeleton, hydrolase, membrane, metal-binding, phosphoprotein |
Biological source | Homo sapiens (human) More |
Cellular location | Apical cell membrane : Q08499 |
Total number of polymer chains | 4 |
Total formula weight | 177286.11 |
Authors | Staker, B.L.,Burgin Jr., A.B. (deposition date: 2009-07-13, release date: 2010-01-05, Last modification date: 2024-02-21) |
Primary citation | Burgin, A.B.,Magnusson, O.T.,Singh, J.,Witte, P.,Staker, B.L.,Bjornsson, J.M.,Thorsteinsdottir, M.,Hrafnsdottir, S.,Hagen, T.,Kiselyov, A.S.,Stewart, L.J.,Gurney, M.E. Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety. Nat.Biotechnol., 28:63-70, 2010 Cited by PubMed: 20037581DOI: 10.1038/nbt.1598 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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