4ZBN

Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor

Summary for 4ZBN

Entry DOI	10.2210/pdb4zbn/pdb
Descriptor	DNA (28-MER), Beta-nerve growth factor, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (4 entities in total)
Functional Keywords	complex, aptamer, immune system-dna complex, immune system/dna
Biological source	Homo sapiens (Human) More
Cellular location	Secreted: P01138
Total number of polymer chains	4
Total formula weight	46860.50
Authors	Davies, D.R.,Edwards, T.E. (deposition date: 2015-04-15, release date: 2015-06-10, Last modification date: 2015-07-15)
Primary citation	Jarvis, T.C.,Davies, D.R.,Hisaminato, A.,Resnicow, D.I.,Gupta, S.,Waugh, S.M.,Nagabukuro, A.,Wadatsu, T.,Hishigaki, H.,Gawande, B.,Zhang, C.,Wolk, S.K.,Mayfield, W.S.,Nakaishi, Y.,Burgin, A.B.,Stewart, L.J.,Edwards, T.E.,Gelinas, A.D.,Schneider, D.J.,Janjic, N. Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor. Structure, 23:1293-1304, 2015 Cited by PubMed: 26027732 DOI: 10.1016/j.str.2015.03.027 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.447 Å)

Structure validation