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4ZBN

Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor

Functional Information from GO Data
ChainGOidnamespacecontents
A0005102molecular_functionsignaling receptor binding
B0005102molecular_functionsignaling receptor binding
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue EPE D 101
ChainResidue
AHIS75
DDC1
DDA19
DDG20

site_idAC2
Number of Residues9
Detailsbinding site for residues DUZ D 10 and DUZ D 11
ChainResidue
DDUZ25
DDG26
DDUZ27
DDG28
AARG59
AARG69
DDA8
DDC9
DDG12

site_idAC3
Number of Residues13
Detailsbinding site for residues DUZ D 16 and DUZ D 17
ChainResidue
ATRP21
ATYR52
BILE31
BLYS32
BPHE101
DDUZ3
DDG4
DDG14
DDG15
DDUZ18
DDA19
DDC21
DDC22

site_idAC4
Number of Residues15
Detailsbinding site for residues DUZ D 17 and DUZ D 18
ChainResidue
ATRP21
ATYR52
BILE31
BLYS32
BPHE101
DDC1
DDA2
DDUZ3
DDG14
DDG15
DDUZ16
DDA19
DDG20
DDC21
DDC22

site_idAC5
Number of Residues12
Detailsbinding site for residues DUZ D 24 and DUZ D 25
ChainResidue
ASER17
AVAL18
ASER19
AARG59
AHOH201
DDG7
DDA8
DDUZ11
DDG12
DDG13
DDG23
DDG26

site_idAC6
Number of Residues9
Detailsbinding site for residues DUZ E 10 and DUZ E 11
ChainResidue
BARG59
BARG69
EDA8
EDC9
EDG12
EDUZ25
EDG26
EDUZ27
EDG28

site_idAC7
Number of Residues9
Detailsbinding site for residues DUZ E 16 and DUZ E 17
ChainResidue
APHE101
BTRP21
BTYR52
EDUZ3
EDG4
EDG15
EDUZ18
EDA19
EDC21

site_idAC8
Number of Residues12
Detailsbinding site for residues DUZ E 17 and DUZ E 18
ChainResidue
ALYS32
APHE101
BHIS4
BTRP21
BTYR52
EDC1
EDA2
EDUZ3
EDG15
EDUZ16
EDA19
EDC21

site_idAC9
Number of Residues12
Detailsbinding site for residues DUZ E 24 and DUZ E 25
ChainResidue
BPHE7
BSER17
BVAL18
BSER19
BARG59
EDG7
EDA8
EDUZ11
EDG12
EDG13
EDG23
EDG26

Functional Information from PROSITE/UniProt
site_idPS00248
Number of Residues14
DetailsNGF_1 Nerve growth factor family signature. GCRGIDskhWnSyC
ChainResidueDetails
AGLY67-CYS80

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: in other chain => ECO:0000250|UniProtKB:P01139
ChainResidueDetails
ATYR52
BTYR52

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P01139
ChainResidueDetails
ALYS88
BLYS88

227111

PDB entries from 2024-11-06

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