4MYQ

Selective Inhibition of the Catalytic Domain Of Human Phosphodiesterase 4B With A-33

Summary for 4MYQ

Entry DOI	10.2210/pdb4myq/pdb
Descriptor	cAMP-specific 3',5'-cyclic phosphodiesterase 4B, (4-{[2-(5-chlorothiophen-2-yl)-5-ethyl-6-methylpyrimidin-4-yl]amino}phenyl)acetic acid, MAGNESIUM ION, ... (7 entities in total)
Functional Keywords	phosphodiesterase, catalytic, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	43499.95
Authors	Fox III, D.,Edwards, T.E. (deposition date: 2013-09-27, release date: 2014-01-01, Last modification date: 2023-09-20)
Primary citation	Fox, D.,Burgin, A.B.,Gurney, M.E. Structural basis for the design of selective phosphodiesterase 4B inhibitors. Cell Signal, 26:657-663, 2014 Cited by PubMed: 24361374 DOI: 10.1016/j.cellsig.2013.12.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation