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6E97
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BU of 6e97 by Molmil
Crystal structure of the aryl acid adenylating enzyme FscC from Fuscachelin NRPS in complex with DHB-adenylate
分子名称: 2,3-dihydroxybenzoate-AMP ligase, 5'-O-[(S)-[(2,3-dihydroxybenzene-1-carbonyl)oxy](hydroxy)phosphoryl]adenosine, GLYCEROL, ...
著者Bruner, S.D, Zagulyaeva, A.A.
登録日2018-07-31
公開日2019-08-21
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Implication of MbtH-like proteins in crystallization of the independent NRPS A domains. Crystal structure of FscC: supporting rationale for revised mechanism of freestanding aryl acid adenylating enzymes
To Be Published
6E8O
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BU of 6e8o by Molmil
Crystal structure of aryl acid adenylating enzyme FscC from Fuscachelin NRPS in complex with AMP
分子名称: 2,3-dihydroxybenzoate-AMP ligase, ADENOSINE MONOPHOSPHATE, GLYCEROL, ...
著者Bruner, S.D, Zagulyaeva, A.A.
登録日2018-07-30
公開日2019-08-21
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Implication of MbtH-like proteins in crystallization of the independent NRPS A domains. Crystal structure of FscC: supporting rationale for revised mechanism of freestanding aryl acid adenylating enzymes
To Be Published
6EBY
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BU of 6eby by Molmil
Crystal structure of the MbtH-like protein FscK bound to the interface forming region of FscH adenylation domain from Thermobifida fusca
分子名称: Amino acid adenylation, Conserved protein MbtH
著者Bruner, S.D, Zagulyaeva, A.A.
登録日2018-08-07
公開日2019-08-21
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Comprehensive analysis of protein-protein interactions between MbtH-like protein FscK and adenylation domains in nonribosomal biosynthesis of Fuscachelins.
To Be Published
6EA3
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Thermobifida fusca FscH adenylation domain complexed with MbtH-like protein FscK and Ser-AMP
分子名称: MbtH-like protein, SERYL ADENYLATE, adenylation domain of Fuscachelin synthetase component H
著者Bruner, S.D, Zagulyaeva, A.A.
登録日2018-08-02
公開日2019-08-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Comprehensive analysis of protein-protein interactions between MbtH-like protein FscK and adenylation domains in nonribosomal biosynthesis of Fuscachelins.
To Be Published
1JMK
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BU of 1jmk by Molmil
Structural Basis for the Cyclization of the Lipopeptide Antibiotic Surfactin by the Thioesterase Domain SrfTE
分子名称: SULFATE ION, Surfactin Synthetase
著者Bruner, S.D, Weber, T, Kohli, R.M, Schwarzer, D, Marahiel, M.A, Walsh, C.T, Stubbs, M.T.
登録日2001-07-18
公開日2002-03-27
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE.
Structure, 10, 2002
1EBM
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BU of 1ebm by Molmil
CRYSTAL STRUCTURE OF THE HUMAN 8-OXOGUANINE GLYCOSYLASE (HOGG1) BOUND TO A SUBSTRATE OLIGONUCLEOTIDE
分子名称: 8-OXOGUANINE DNA GLYCOSYLASE, CALCIUM ION, DNA (5'-D(*GP*CP*GP*TP*CP*CP*AP*(8OG)P*GP*TP*CP*TP*AP*CP*C)-3'), ...
著者Bruner, S.D, Norman, D.P, Verdine, G.L.
登録日2000-01-24
公開日2000-03-20
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA.
Nature, 403, 2000
2NP9
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BU of 2np9 by Molmil
Crystal structure of a dioxygenase in the Crotonase superfamily
分子名称: DpgC, OXYGEN MOLECULE, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL (3R)-4-({3-[(2-{[(3,5-DIHYDROXYPHENYL)ACETYL]AMINO}ETHYL)AMINO]-3-OXOPROPYL}AMINO)-3-HYDROXY-2,2-DIMETHYL-4-OXOBUTYL DIHYDROGEN DIPHOSPHATE
著者Bruner, S.D, Widboom, P.F, Fielding, E.N.
登録日2006-10-26
公開日2007-05-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Structural basis for cofactor-independent dioxygenation in vancomycin biosynthesis.
Nature, 447, 2007
1HU0
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BU of 1hu0 by Molmil
CRYSTAL STRUCTURE OF AN HOGG1-DNA BOROHYDRIDE TRAPPED INTERMEDIATE COMPLEX
分子名称: 5'-D(*GP*CP*GP*TP*CP*CP*AP*(PED)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 8-OXOGUANINE, ...
著者Fromme, J.C, Bruner, S.D, Yang, W, Karplus, M, Verdine, G.L.
登録日2001-01-03
公開日2003-02-25
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Product-Assisted Catalysis in base-excision DNA Repair
Nat.Struct.Biol., 10, 2003
7MTT
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BU of 7mtt by Molmil
Crystal structure of colibactin self-resistance protein ClbS in complex with two molecules of CHES
分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Colibactin self-protection protein ClbS
著者Tripathi, P, Bruner, S.D.
登録日2021-05-13
公開日2021-05-26
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural Basis for the Interactions of the Colibactin Resistance Gene Product ClbS with DNA.
Biochemistry, 60, 2021
7MTL
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BU of 7mtl by Molmil
Crystal structure of colibactin self-resistance protein ClbS in complex with a dsDNA
分子名称: Colibactin self-protection protein ClbS, DNA (5'-D(*AP*AP*TP*TP*CP*CP*CP*AP*CP*TP*TP*CP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*GP*AP*AP*GP*TP*GP*GP*GP*AP*AP*TP*T)-3')
著者Tripathi, P, Bruner, S.D.
登録日2021-05-13
公開日2021-05-26
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.446 Å)
主引用文献Structural Basis for the Interactions of the Colibactin Resistance Gene Product ClbS with DNA.
Biochemistry, 60, 2021
7RK0
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BU of 7rk0 by Molmil
Crystal structure of Thermovibrio ammonificans THI4
分子名称: 2-[(E)-[(4R)-5-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-4-oxidanyl-3-oxidanylidene-pentan-2-ylidene]amino]ethanoic acid, FE (III) ION, Thiamine thiazole synthase
著者Li, Q, Bruner, S.D.
登録日2021-07-21
公開日2021-09-01
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Structure and function of aerotolerant, multiple-turnover THI4 thiazole synthases.
Biochem.J., 478, 2021
6UFI
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BU of 6ufi by Molmil
W96Y Oxalate Decarboxylase (Bacillus subtilis)
分子名称: CHLORIDE ION, Cupin domain-containing protein, GLYCEROL, ...
著者Pastore, A.J, Burg, M.J, Twahir, U.T, Bruner, S.D, Angerhofer, A.
登録日2019-09-24
公開日2020-09-30
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Oxalate decarboxylase uses electron hole hopping for catalysis.
J.Biol.Chem., 297, 2021
8UTL
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BU of 8utl by Molmil
Bovine trypsin in complex with Thr3Dap mutated microviridin J
分子名称: CALCIUM ION, Cationic trypsin, GLYCEROL, ...
著者Chen, W, Bruner, S.D.
登録日2023-10-31
公開日2024-02-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Alternative Linkage Chemistries in the Chemoenzymatic Synthesis of Microviridin-Based Cyclic Peptides.
Org.Lett., 26, 2024
8UO7
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BU of 8uo7 by Molmil
Bovine trypsin in complex with deacetylated wild type microviridin J
分子名称: CALCIUM ION, Cationic trypsin, Deacetylated wildtype microviridin J, ...
著者Chen, W, Bruner, S.D.
登録日2023-10-19
公開日2024-02-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Alternative Linkage Chemistries in the Chemoenzymatic Synthesis of Microviridin-Based Cyclic Peptides.
Org.Lett., 26, 2024
1FN7
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BU of 1fn7 by Molmil
COUPLING OF DAMAGE RECOGNITION AND CATALYSIS BY A HUMAN BASE-EXCISION DNA REPAIR PROTEIN
分子名称: 8-OXOGUANINE DNA GLYCOSYLASE 1, CALCIUM ION, DNA (5'-D(*GP*CP*GP*TP*CP*CP*AP*(3DR)P*GP*TP*CP*TP*AP*CP*C)-3'), ...
著者Norman, D.P.G, Bruner, S.D, Verdine, G.L.
登録日2000-08-21
公開日2001-04-21
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Coupling of substrate recognition and catalysis by a human base-excision DNA repair protein.
J.Am.Chem.Soc., 123, 2001
8ES6
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BU of 8es6 by Molmil
Crystal structure of an unusual amidase ClbL from colibactin gene cluster
分子名称: Colibactin biosynthesis amidase ClbL
著者Tripathi, P, Bruner, S.D.
登録日2022-10-13
公開日2023-09-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis of the amidase ClbL central to the biosynthesis of the genotoxin colibactin.
Acta Crystallogr D Struct Biol, 79, 2023
3KDY
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BU of 3kdy by Molmil
X-ray crystal structure of tyrosine aminomutase mutant construct
分子名称: Histidine ammonia-lyase
著者Cooke, H.A, Bruner, S.D.
登録日2009-10-23
公開日2010-07-07
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Probing the active site of MIO-dependent aminomutases, key catalysts in the biosynthesis of beta-amino acids incorporated in secondary metabolites
Biopolymers, 93, 2010
3KDZ
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BU of 3kdz by Molmil
X-ray crystal structure of a tyrosine aminomutase mutant construct with bound ligand
分子名称: Histidine ammonia-lyase, TYROSINE
著者Cooke, H.A, Bruner, S.D.
登録日2009-10-23
公開日2010-07-07
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Probing the active site of MIO-dependent aminomutases, key catalysts in the biosynthesis of beta-amino acids incorporated in secondary metabolites
Biopolymers, 93, 2010
8TYJ
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BU of 8tyj by Molmil
Crystal structure of SARS-CoV-2 nsp10/nsp16 complex with bound SAH
分子名称: 2'-O-methyltransferase, GLYCEROL, Non-structural protein 10, ...
著者Patel, K.P, Bruner, S.D.
登録日2023-08-25
公開日2024-01-24
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of SARS-CoV-2 nsp10/nsp16 complex with bound SAH
To Be Published
6B9V
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BU of 6b9v by Molmil
Crystal Structure of a New Diphosphatase from the PhnP Family
分子名称: Beta-lactamase-like protein, MANGANESE (II) ION, PHOSPHATE ION, ...
著者Li, Q, Bruner, S.D.
登録日2017-10-11
公開日2018-10-17
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献An unusual diphosphatase from the PhnP family cleaves reactive FAD photoproducts.
Biochem.J., 475, 2018
6ANR
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BU of 6anr by Molmil
Crystal structure of a self resistance protein ClbS from colibactin biosynthetic gene cluster
分子名称: Colibactin self-protection protein ClbS
著者Tripathi, P, Bruner, S.D.
登録日2017-08-14
公開日2018-06-27
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.098 Å)
主引用文献ClbS Is a Cyclopropane Hydrolase That Confers Colibactin Resistance.
J. Am. Chem. Soc., 139, 2017
1LWW
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BU of 1lww by Molmil
Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-bromoguanine
分子名称: 5'-D(*GP*CP*GP*TP*CP*CP*AP*(PED)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 8-BROMOGUANINE, ...
著者Fromme, J.C, Bruner, S.D, Yang, W, Karplus, M, Verdine, G.L.
登録日2002-06-03
公開日2003-02-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Product-Assisted Catalysis in Base Excision DNA Repair
Nat.Struct.Biol., 10, 2003
1LWV
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Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-aminoguanine
分子名称: 5'-D(*GP*CP*GP*TP*CP*CP*AP*(PED)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 8-AMINOGUANINE, ...
著者Fromme, J.C, Bruner, S.D, Yang, W, Karplus, M, Verdine, G.L.
登録日2002-06-03
公開日2003-02-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Product-Assisted Catalysis in Base Excision DNA Repair
Nat.Struct.Biol., 10, 2003
7LC7
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BU of 7lc7 by Molmil
Crystal structure of epoxyqueuosine reductase QueH in complex with GMP from Thermotoga maritima
分子名称: CHLORIDE ION, Epoxyqueuosine reductase QueH, FE (III) ION, ...
著者Li, Q, Bruner, S.D.
登録日2021-01-09
公開日2022-01-12
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献The epoxyqueuosine reductase QueH in the biosynthesis of tRNA queuosine is a unique metalloenzyme
To Be Published
7M4S
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BU of 7m4s by Molmil
Crystal structure of macrocyclase AMdnB from Anabaena sp. PCC 7120
分子名称: AMdnB protein
著者Li, G, Bruner, S.D.
登録日2021-03-22
公開日2021-11-03
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.493 Å)
主引用文献Structural and biochemical studies of an iterative ribosomal peptide macrocyclase.
Proteins, 90, 2022

 

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