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Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者	Herrera, N.G, Morano, N.C, Celikgil, A, Georgiev, G.I, Malonis, R, Lee, J.H, Tong, K, Vergnolle, O, Massimi, A, Yen, L.Y, Noble, A.J, Kopylov, M, Bonanno, J.B, Garrett-Thompson, S.C, Hayes, D.B, Brenowitz, M, Garforth, S.J, Eng, E.T, Lai, J.R, Almo, S.C.
登録日	2020-05-28
公開日	2020-06-10
最終更新日	2021-01-27
実験手法	ELECTRON MICROSCOPY (3.22 Å)
主引用文献	Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis. Biorxiv, 2020

3KO0

Structure of the tfp-ca2+-bound activated form of the s100a4 Metastasis factor
分子名称:	10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE, CALCIUM ION, Protein S100-A4
著者	Malashkevich, V.N, Dulyaninova, N.G, Knight, D, Almo, S.C, Bresnick, A.R.
登録日	2009-11-12
公開日	2010-05-26
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Phenothiazines inhibit S100A4 function by inducing protein oligomerization. Proc.Natl.Acad.Sci.USA, 107, 2010

6AX5

RPT1 region of INI1/SNF5/SMARCB1_HUMAN - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1.
分子名称:	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
著者	Girvin, M.E, Cahill, S.M, Harris, R, Cowburn, D, Spira, M, Wu, X, Prakash, R, Bernowitz, M, Almo, S.C, Kalpana, G.V.
登録日	2017-09-06
公開日	2017-10-18
最終更新日	2024-05-15
実験手法	SOLUTION NMR
主引用文献	INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication. Nat Commun, 12, 2021

2QE3

Crystal structure of human tl1a extracellular domain
分子名称:	CHLORIDE ION, TNF superfamily ligand TL1A
著者	Zhan, C, Yan, Q, Patskovsky, Y, Shi, W, Toro, R, Bonanno, J, Nathenson, S.G, Almo, S.C.
登録日	2007-06-22
公開日	2007-07-17
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Biochemical and structural characterization of the human TL1A ectodomain. Biochemistry, 48, 2009

2QDN

Crystal Structure of mouse GITRL
分子名称:	GITR ligand
著者	Chattopadhyay, K, Ramagopal, U.A, Nathenson, S.G, Almo, S.C.
登録日	2007-06-21
公開日	2008-01-01
最終更新日	2017-10-18
実験手法	X-RAY DIFFRACTION (2.09 Å)
主引用文献	Evolution of GITRL immune function: murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily. Proc.Natl.Acad.Sci.Usa, 105, 2008

4G56

Crystal Structure of full length PRMT5/MEP50 complexes from Xenopus laevis
分子名称:	Hsl7 protein, MGC81050 protein, S-ADENOSYL-L-HOMOCYSTEINE
著者	Ho, M, Wilczek, C, Bonanno, J, Shechter, D, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC)
登録日	2012-07-17
公開日	2012-10-03
最終更新日	2017-11-15
実験手法	X-RAY DIFFRACTION (2.95 Å)
主引用文献	Structure of the arginine methyltransferase PRMT5-MEP50 reveals a mechanism for substrate specificity Plos One, 8, 2013

3K51

Crystal Structure of DcR3-TL1A complex
分子名称:	Decoy receptor 3, Tumor necrosis factor ligand superfamily member 15, secreted form
著者	Zhan, C, Patskovsky, Y, Yan, Q, Li, Z, Ramagopal, U.A, Nathenson, S.G, Almo, S.C.
登録日	2009-10-06
公開日	2010-10-13
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.45 Å)
主引用文献	Decoy Strategies: The Structure of TL1A:DcR3 Complex. Structure, 19, 2011

8VWX

Human Bcl-2 (G101V Mutant)/Bcl-xL Chimera Fused to Maltose-Binding Protein
分子名称:	Maltose/maltodextrin-binding periplasmic protein fused to apoptosis regulator Bcl-2/Bcl-xL chimera
著者	Baird, J, Holliday, M.
登録日	2024-02-02
公開日	2024-10-02
実験手法	X-RAY DIFFRACTION (1.77 Å)
主引用文献	Complementary Backbone and Side-Chain Analysis of Drug-Protein Interactions: Combining Hydrogen/Deuterium Exchange and Protein Oxidative Footprinting to Discriminate the Binding of Small Molecule Therapeutics To Be Published

8VWZ

Human Bcl-2 (G101V Mutant)/Bcl-xL Chimera Fused to MBP in Complex with Inhibitor S55746
分子名称:	DI(HYDROXYETHYL)ETHER, Maltose/maltodextrin-binding periplasmic protein fused to apoptosis regulator Bcl-2/Bcl-xL chimera, ~{N}-(4-hydroxyphenyl)-3-[6-[[(3~{S})-3-(morpholin-4-ylmethyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]-1,3-benzodioxol-5-yl]-~{N}-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide
著者	Baird, J, Holliday, M.
登録日	2024-02-02
公開日	2024-10-02
実験手法	X-RAY DIFFRACTION (2.33 Å)
主引用文献	Complementary Backbone and Side-Chain Analysis of Drug-Protein Interactions: Combining Hydrogen/Deuterium Exchange and Protein Oxidative Footprinting to Discriminate the Binding of Small Molecule Therapeutics To Be Published

8VXN

Human Bcl-2/Bcl-xL Chimera Fused to Maltose-Binding Protein
分子名称:	Maltose/maltodextrin-binding periplasmic protein fused to apoptosis regulator Bcl-2/Bcl-xL chimera
著者	Baird, J, Holliday, M.
登録日	2024-02-05
公開日	2024-10-02
実験手法	X-RAY DIFFRACTION (2.09 Å)
主引用文献	Complementary Backbone and Side-Chain Analysis of Drug-Protein Interactions: Combining Hydrogen/Deuterium Exchange and Protein Oxidative Footprinting to Discriminate the Binding of Small Molecule Therapeutics To Be Published

8VXM

Human Bcl-2/Bcl-xL Chimera Fused to MBP in Complex with Inhibitor S55746
分子名称:	DI(HYDROXYETHYL)ETHER, Maltose/maltodextrin-binding periplasmic protein fused to apoptosis regulator Bcl-2/Bcl-xL chimera, ~{N}-(4-hydroxyphenyl)-3-[6-[[(3~{S})-3-(morpholin-4-ylmethyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]-1,3-benzodioxol-5-yl]-~{N}-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide
著者	Baird, J, Holliday, M.
登録日	2024-02-05
公開日	2024-10-02
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Complementary Backbone and Side-Chain Analysis of Drug-Protein Interactions: Combining Hydrogen/Deuterium Exchange and Protein Oxidative Footprinting to Discriminate the Binding of Small Molecule Therapeutics To Be Published

3B9I

Crystal Structure of mouse GITRL at 2.5 A.
分子名称:	GITR ligand
著者	Chattopadhyay, K, Ramagopal, U.A, Nathenson, S.G, Almo, S.C.
登録日	2007-11-05
公開日	2008-01-01
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (2.49 Å)
主引用文献	Evolution of GITRL immune function: murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily. Proc.Natl.Acad.Sci.Usa, 105, 2008

3MHD

Crystal structure of DCR3
分子名称:	Tumor necrosis factor receptor superfamily member 6B
著者	Zhan, C, Patskovsky, Y, Yan, Q, Li, Z, Ramagopal, U.A, Nathenson, S.G, Almo, S.C.
登録日	2010-04-07
公開日	2011-02-23
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.901 Å)
主引用文献	Decoy Strategies: The Structure of TL1A:DcR3 Complex. Structure, 19, 2011

3MI8

The structure of TL1A-DCR3 COMPLEX
分子名称:	TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 15, SECRETED FORM, Tumor necrosis factor receptor superfamily member 6B
著者	Zhan, C, Patskovsky, Y, Yan, Q, Li, Z, Ramagopal, U.A, Nathenson, S.G, Almo, S.C.
登録日	2010-04-09
公開日	2011-02-23
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.951 Å)
主引用文献	Decoy Strategies: The Structure of TL1A:DcR3 Complex. Structure, 19, 2011

4RP4

Crystal Structure of the L27 domain of Discs Large 1 (target ID NYSGRC-010766) from Drosophila melanogaster (space group P212121)
分子名称:	Disks large 1 tumor suppressor protein, FORMIC ACID
著者	Ghosh, A, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC)
登録日	2014-10-29
公開日	2014-11-26
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (1.42 Å)
主引用文献	Structures of the L27 Domain of Disc Large Homologue 1 Protein Illustrate a Self-Assembly Module. Biochemistry, 57, 2018

4RP3

Crystal Structure of the L27 Domain of Discs Large 1 (target ID NYSGRC-010766) from Drosophila melanogaster bound to a potassium ion (space group P212121)
分子名称:	CHLORIDE ION, Disks large 1 tumor suppressor protein, FORMIC ACID, ...
著者	Ghosh, A, Ramagopal, U, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC)
登録日	2014-10-29
公開日	2014-11-26
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (1.36 Å)
主引用文献	Structures of the L27 Domain of Disc Large Homologue 1 Protein Illustrate a Self-Assembly Module. Biochemistry, 57, 2018

4RP5

Crystal Structure of the L27 domain of Discs Large 1 (target ID NYSGRC-010766) from Drosophila melanogaster (space group P21)
分子名称:	CHLORIDE ION, Disks large 1 tumor suppressor protein
著者	Ghosh, A, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC)
登録日	2014-10-29
公開日	2014-11-26
最終更新日	2023-12-06
実験手法	X-RAY DIFFRACTION (1.65 Å)
主引用文献	Structures of the L27 Domain of Disc Large Homologue 1 Protein Illustrate a Self-Assembly Module. Biochemistry, 57, 2018

2Q1M

Crystal Structure of human GITRL
分子名称:	Tumor necrosis factor ligand superfamily member 18
著者	Chattopadhyay, K, Ramagopal, U.A, Nathenson, S.G, Almo, S.C.
登録日	2007-05-24
公開日	2007-11-13
最終更新日	2017-10-18
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function. Proc.Natl.Acad.Sci.USA, 104, 2007

2R32

Crystal Structure of human GITRL variant
分子名称:	GCN4-pII/Tumor necrosis factor ligand superfamily member 18 fusion protein, SULFATE ION
著者	Chattopadhyay, K, Ramagopal, U.A, Nathenson, S.G, Almo, S.C.
登録日	2007-08-28
公開日	2007-11-20
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (1.95 Å)
主引用文献	Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function. Proc.Natl.Acad.Sci.USA, 104, 2007

2R30

Crystal Structure of human GITRL mutant
分子名称:	Tumor necrosis factor ligand superfamily member 18
著者	Chattopadhyay, K, Ramagopal, U.A, Nathenson, S.G, Almo, S.C.
登録日	2007-08-28
公開日	2007-11-13
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (3.2 Å)
主引用文献	Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function. Proc.Natl.Acad.Sci.USA, 104, 2007

2RJK

Crystal Structure of Human TL1A Extracellular Domain C95S Mutant
分子名称:	TNF superfamily ligand TL1A
著者	Zhan, C, Yan, Q, Patskovsky, Y, Shi, W, Ramagopal, U.A, Toro, R, Bonanno, J, Nathenson, S.G, Almo, S.C.
登録日	2007-10-15
公開日	2008-08-26
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Biochemical and structural characterization of the human TL1A ectodomain. Biochemistry, 48, 2009

2RJL

Crystal structure of human TL1A extracellular domain C95S/C135S mutant
分子名称:	TNF superfamily ligand TL1A
著者	Zhan, C, Patskovsky, Y, Yan, Q, Shi, W, Toro, R, Bonanno, J, Nathenson, S.G, Almo, S.C.
登録日	2007-10-15
公開日	2008-08-26
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (2.05 Å)
主引用文献	Biochemical and structural characterization of the human TL1A ectodomain. Biochemistry, 48, 2009

2N8L

Zipcode-binding-protein-1 KH3KH4(DD) domains in complex with the KH3 RNA target
分子名称:	Insulin-like growth factor 2 mRNA-binding protein 1, RNA (5'-R(PGPCPAPCPAPCPCPC)-3')
著者	Nicastro, G, Candel, A.M, Ramos, A, Hollingworth, D.
登録日	2015-10-21
公開日	2017-01-25
最終更新日	2024-05-15
実験手法	SOLUTION NMR
主引用文献	Zipcode-binding-protein-1 KH3KH4(DD) domains in complex with the RNA target GCACACCC To be Published

2N8M

Zipcode-binding-protein-1 KH3(DD)KH4 domains in complex with the KH4 RNA target
分子名称:	Insulin-like growth factor 2 mRNA-binding protein 1, RNA (5'-R(PUPCPGPGPAPCP*U)-3')
著者	Nicastro, G, Ramos, A, Candel, A, Hollingworth, D.
登録日	2015-10-21
公開日	2017-01-25
最終更新日	2024-05-15
実験手法	SOLUTION NMR
主引用文献	Zipcode-binding-protein-1 KH3(DD)KH4 domains in complex with the RNA target UCGGACU To be Published

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