3KO0

Structure of the tfp-ca2+-bound activated form of the s100a4 Metastasis factor

Summary for 3KO0

Entry DOI	10.2210/pdb3ko0/pdb
Descriptor	Protein S100-A4, 10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE, CALCIUM ION, ... (4 entities in total)
Functional Keywords	mts1, s100a4, tfp, ca2+, oligomerization, acetylation, calcium, metal binding protein
Biological source	Homo sapiens (human)
Total number of polymer chains	20
Total formula weight	252813.72
Authors	Malashkevich, V.N.,Dulyaninova, N.G.,Knight, D.,Almo, S.C.,Bresnick, A.R. (deposition date: 2009-11-12, release date: 2010-05-26, Last modification date: 2024-02-21)
Primary citation	Malashkevich, V.N.,Dulyaninova, N.G.,Ramagopal, U.A.,Liriano, M.A.,Varney, K.M.,Knight, D.,Brenowitz, M.,Weber, D.J.,Almo, S.C.,Bresnick, A.R. Phenothiazines inhibit S100A4 function by inducing protein oligomerization. Proc.Natl.Acad.Sci.USA, 107:8605-8610, 2010 Cited by PubMed: 20421509 DOI: 10.1073/pnas.0913660107 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation