3KO0

Structure of the tfp-ca2+-bound activated form of the s100a4 Metastasis factor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001837	biological_process	epithelial to mesenchymal transition
A	0003723	molecular_function	RNA binding
A	0003779	molecular_function	actin binding
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0031012	cellular_component	extracellular matrix
A	0042056	molecular_function	chemoattractant activity
A	0042802	molecular_function	identical protein binding
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0046872	molecular_function	metal ion binding
A	0046914	molecular_function	transition metal ion binding
A	0048306	molecular_function	calcium-dependent protein binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050786	molecular_function	RAGE receptor binding
A	0050918	biological_process	positive chemotaxis
A	0070062	cellular_component	extracellular exosome
B	0001837	biological_process	epithelial to mesenchymal transition
B	0003723	molecular_function	RNA binding
B	0003779	molecular_function	actin binding
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0031012	cellular_component	extracellular matrix
B	0042056	molecular_function	chemoattractant activity
B	0042802	molecular_function	identical protein binding
B	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
B	0046872	molecular_function	metal ion binding
B	0046914	molecular_function	transition metal ion binding
B	0048306	molecular_function	calcium-dependent protein binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0050786	molecular_function	RAGE receptor binding
B	0050918	biological_process	positive chemotaxis
B	0070062	cellular_component	extracellular exosome
C	0001837	biological_process	epithelial to mesenchymal transition
C	0003723	molecular_function	RNA binding
C	0003779	molecular_function	actin binding
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0031012	cellular_component	extracellular matrix
C	0042056	molecular_function	chemoattractant activity
C	0042802	molecular_function	identical protein binding
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0046872	molecular_function	metal ion binding
C	0046914	molecular_function	transition metal ion binding
C	0048306	molecular_function	calcium-dependent protein binding
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0050786	molecular_function	RAGE receptor binding
C	0050918	biological_process	positive chemotaxis
C	0070062	cellular_component	extracellular exosome
D	0001837	biological_process	epithelial to mesenchymal transition
D	0003723	molecular_function	RNA binding
D	0003779	molecular_function	actin binding
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0031012	cellular_component	extracellular matrix
D	0042056	molecular_function	chemoattractant activity
D	0042802	molecular_function	identical protein binding
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0046872	molecular_function	metal ion binding
D	0046914	molecular_function	transition metal ion binding
D	0048306	molecular_function	calcium-dependent protein binding
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0050786	molecular_function	RAGE receptor binding
D	0050918	biological_process	positive chemotaxis
D	0070062	cellular_component	extracellular exosome
E	0001837	biological_process	epithelial to mesenchymal transition
E	0003723	molecular_function	RNA binding
E	0003779	molecular_function	actin binding
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0031012	cellular_component	extracellular matrix
E	0042056	molecular_function	chemoattractant activity
E	0042802	molecular_function	identical protein binding
E	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
E	0046872	molecular_function	metal ion binding
E	0046914	molecular_function	transition metal ion binding
E	0048306	molecular_function	calcium-dependent protein binding
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0050786	molecular_function	RAGE receptor binding
E	0050918	biological_process	positive chemotaxis
E	0070062	cellular_component	extracellular exosome
F	0001837	biological_process	epithelial to mesenchymal transition
F	0003723	molecular_function	RNA binding
F	0003779	molecular_function	actin binding
F	0005509	molecular_function	calcium ion binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0031012	cellular_component	extracellular matrix
F	0042056	molecular_function	chemoattractant activity
F	0042802	molecular_function	identical protein binding
F	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
F	0046872	molecular_function	metal ion binding
F	0046914	molecular_function	transition metal ion binding
F	0048306	molecular_function	calcium-dependent protein binding
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0050786	molecular_function	RAGE receptor binding
F	0050918	biological_process	positive chemotaxis
F	0070062	cellular_component	extracellular exosome
G	0001837	biological_process	epithelial to mesenchymal transition
G	0003723	molecular_function	RNA binding
G	0003779	molecular_function	actin binding
G	0005509	molecular_function	calcium ion binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0031012	cellular_component	extracellular matrix
G	0042056	molecular_function	chemoattractant activity
G	0042802	molecular_function	identical protein binding
G	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
G	0046872	molecular_function	metal ion binding
G	0046914	molecular_function	transition metal ion binding
G	0048306	molecular_function	calcium-dependent protein binding
G	0048471	cellular_component	perinuclear region of cytoplasm
G	0050786	molecular_function	RAGE receptor binding
G	0050918	biological_process	positive chemotaxis
G	0070062	cellular_component	extracellular exosome
H	0001837	biological_process	epithelial to mesenchymal transition
H	0003723	molecular_function	RNA binding
H	0003779	molecular_function	actin binding
H	0005509	molecular_function	calcium ion binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0031012	cellular_component	extracellular matrix
H	0042056	molecular_function	chemoattractant activity
H	0042802	molecular_function	identical protein binding
H	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
H	0046872	molecular_function	metal ion binding
H	0046914	molecular_function	transition metal ion binding
H	0048306	molecular_function	calcium-dependent protein binding
H	0048471	cellular_component	perinuclear region of cytoplasm
H	0050786	molecular_function	RAGE receptor binding
H	0050918	biological_process	positive chemotaxis
H	0070062	cellular_component	extracellular exosome
I	0001837	biological_process	epithelial to mesenchymal transition
I	0003723	molecular_function	RNA binding
I	0003779	molecular_function	actin binding
I	0005509	molecular_function	calcium ion binding
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0031012	cellular_component	extracellular matrix
I	0042056	molecular_function	chemoattractant activity
I	0042802	molecular_function	identical protein binding
I	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
I	0046872	molecular_function	metal ion binding
I	0046914	molecular_function	transition metal ion binding
I	0048306	molecular_function	calcium-dependent protein binding
I	0048471	cellular_component	perinuclear region of cytoplasm
I	0050786	molecular_function	RAGE receptor binding
I	0050918	biological_process	positive chemotaxis
I	0070062	cellular_component	extracellular exosome
J	0001837	biological_process	epithelial to mesenchymal transition
J	0003723	molecular_function	RNA binding
J	0003779	molecular_function	actin binding
J	0005509	molecular_function	calcium ion binding
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0031012	cellular_component	extracellular matrix
J	0042056	molecular_function	chemoattractant activity
J	0042802	molecular_function	identical protein binding
J	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
J	0046872	molecular_function	metal ion binding
J	0046914	molecular_function	transition metal ion binding
J	0048306	molecular_function	calcium-dependent protein binding
J	0048471	cellular_component	perinuclear region of cytoplasm
J	0050786	molecular_function	RAGE receptor binding
J	0050918	biological_process	positive chemotaxis
J	0070062	cellular_component	extracellular exosome
K	0001837	biological_process	epithelial to mesenchymal transition
K	0003723	molecular_function	RNA binding
K	0003779	molecular_function	actin binding
K	0005509	molecular_function	calcium ion binding
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0031012	cellular_component	extracellular matrix
K	0042056	molecular_function	chemoattractant activity
K	0042802	molecular_function	identical protein binding
K	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
K	0046872	molecular_function	metal ion binding
K	0046914	molecular_function	transition metal ion binding
K	0048306	molecular_function	calcium-dependent protein binding
K	0048471	cellular_component	perinuclear region of cytoplasm
K	0050786	molecular_function	RAGE receptor binding
K	0050918	biological_process	positive chemotaxis
K	0070062	cellular_component	extracellular exosome
L	0001837	biological_process	epithelial to mesenchymal transition
L	0003723	molecular_function	RNA binding
L	0003779	molecular_function	actin binding
L	0005509	molecular_function	calcium ion binding
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0031012	cellular_component	extracellular matrix
L	0042056	molecular_function	chemoattractant activity
L	0042802	molecular_function	identical protein binding
L	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
L	0046872	molecular_function	metal ion binding
L	0046914	molecular_function	transition metal ion binding
L	0048306	molecular_function	calcium-dependent protein binding
L	0048471	cellular_component	perinuclear region of cytoplasm
L	0050786	molecular_function	RAGE receptor binding
L	0050918	biological_process	positive chemotaxis
L	0070062	cellular_component	extracellular exosome
M	0001837	biological_process	epithelial to mesenchymal transition
M	0003723	molecular_function	RNA binding
M	0003779	molecular_function	actin binding
M	0005509	molecular_function	calcium ion binding
M	0005515	molecular_function	protein binding
M	0005576	cellular_component	extracellular region
M	0005615	cellular_component	extracellular space
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0031012	cellular_component	extracellular matrix
M	0042056	molecular_function	chemoattractant activity
M	0042802	molecular_function	identical protein binding
M	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
M	0046872	molecular_function	metal ion binding
M	0046914	molecular_function	transition metal ion binding
M	0048306	molecular_function	calcium-dependent protein binding
M	0048471	cellular_component	perinuclear region of cytoplasm
M	0050786	molecular_function	RAGE receptor binding
M	0050918	biological_process	positive chemotaxis
M	0070062	cellular_component	extracellular exosome
N	0001837	biological_process	epithelial to mesenchymal transition
N	0003723	molecular_function	RNA binding
N	0003779	molecular_function	actin binding
N	0005509	molecular_function	calcium ion binding
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005615	cellular_component	extracellular space
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005737	cellular_component	cytoplasm
N	0031012	cellular_component	extracellular matrix
N	0042056	molecular_function	chemoattractant activity
N	0042802	molecular_function	identical protein binding
N	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
N	0046872	molecular_function	metal ion binding
N	0046914	molecular_function	transition metal ion binding
N	0048306	molecular_function	calcium-dependent protein binding
N	0048471	cellular_component	perinuclear region of cytoplasm
N	0050786	molecular_function	RAGE receptor binding
N	0050918	biological_process	positive chemotaxis
N	0070062	cellular_component	extracellular exosome
O	0001837	biological_process	epithelial to mesenchymal transition
O	0003723	molecular_function	RNA binding
O	0003779	molecular_function	actin binding
O	0005509	molecular_function	calcium ion binding
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005615	cellular_component	extracellular space
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0031012	cellular_component	extracellular matrix
O	0042056	molecular_function	chemoattractant activity
O	0042802	molecular_function	identical protein binding
O	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
O	0046872	molecular_function	metal ion binding
O	0046914	molecular_function	transition metal ion binding
O	0048306	molecular_function	calcium-dependent protein binding
O	0048471	cellular_component	perinuclear region of cytoplasm
O	0050786	molecular_function	RAGE receptor binding
O	0050918	biological_process	positive chemotaxis
O	0070062	cellular_component	extracellular exosome
P	0001837	biological_process	epithelial to mesenchymal transition
P	0003723	molecular_function	RNA binding
P	0003779	molecular_function	actin binding
P	0005509	molecular_function	calcium ion binding
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005615	cellular_component	extracellular space
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0031012	cellular_component	extracellular matrix
P	0042056	molecular_function	chemoattractant activity
P	0042802	molecular_function	identical protein binding
P	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
P	0046872	molecular_function	metal ion binding
P	0046914	molecular_function	transition metal ion binding
P	0048306	molecular_function	calcium-dependent protein binding
P	0048471	cellular_component	perinuclear region of cytoplasm
P	0050786	molecular_function	RAGE receptor binding
P	0050918	biological_process	positive chemotaxis
P	0070062	cellular_component	extracellular exosome
Q	0001837	biological_process	epithelial to mesenchymal transition
Q	0003723	molecular_function	RNA binding
Q	0003779	molecular_function	actin binding
Q	0005509	molecular_function	calcium ion binding
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005615	cellular_component	extracellular space
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0031012	cellular_component	extracellular matrix
Q	0042056	molecular_function	chemoattractant activity
Q	0042802	molecular_function	identical protein binding
Q	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
Q	0046872	molecular_function	metal ion binding
Q	0046914	molecular_function	transition metal ion binding
Q	0048306	molecular_function	calcium-dependent protein binding
Q	0048471	cellular_component	perinuclear region of cytoplasm
Q	0050786	molecular_function	RAGE receptor binding
Q	0050918	biological_process	positive chemotaxis
Q	0070062	cellular_component	extracellular exosome
R	0001837	biological_process	epithelial to mesenchymal transition
R	0003723	molecular_function	RNA binding
R	0003779	molecular_function	actin binding
R	0005509	molecular_function	calcium ion binding
R	0005515	molecular_function	protein binding
R	0005576	cellular_component	extracellular region
R	0005615	cellular_component	extracellular space
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0031012	cellular_component	extracellular matrix
R	0042056	molecular_function	chemoattractant activity
R	0042802	molecular_function	identical protein binding
R	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
R	0046872	molecular_function	metal ion binding
R	0046914	molecular_function	transition metal ion binding
R	0048306	molecular_function	calcium-dependent protein binding
R	0048471	cellular_component	perinuclear region of cytoplasm
R	0050786	molecular_function	RAGE receptor binding
R	0050918	biological_process	positive chemotaxis
R	0070062	cellular_component	extracellular exosome
S	0001837	biological_process	epithelial to mesenchymal transition
S	0003723	molecular_function	RNA binding
S	0003779	molecular_function	actin binding
S	0005509	molecular_function	calcium ion binding
S	0005515	molecular_function	protein binding
S	0005576	cellular_component	extracellular region
S	0005615	cellular_component	extracellular space
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005737	cellular_component	cytoplasm
S	0031012	cellular_component	extracellular matrix
S	0042056	molecular_function	chemoattractant activity
S	0042802	molecular_function	identical protein binding
S	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
S	0046872	molecular_function	metal ion binding
S	0046914	molecular_function	transition metal ion binding
S	0048306	molecular_function	calcium-dependent protein binding
S	0048471	cellular_component	perinuclear region of cytoplasm
S	0050786	molecular_function	RAGE receptor binding
S	0050918	biological_process	positive chemotaxis
S	0070062	cellular_component	extracellular exosome
T	0001837	biological_process	epithelial to mesenchymal transition
T	0003723	molecular_function	RNA binding
T	0003779	molecular_function	actin binding
T	0005509	molecular_function	calcium ion binding
T	0005515	molecular_function	protein binding
T	0005576	cellular_component	extracellular region
T	0005615	cellular_component	extracellular space
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005737	cellular_component	cytoplasm
T	0031012	cellular_component	extracellular matrix
T	0042056	molecular_function	chemoattractant activity
T	0042802	molecular_function	identical protein binding
T	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
T	0046872	molecular_function	metal ion binding
T	0046914	molecular_function	transition metal ion binding
T	0048306	molecular_function	calcium-dependent protein binding
T	0048471	cellular_component	perinuclear region of cytoplasm
T	0050786	molecular_function	RAGE receptor binding
T	0050918	biological_process	positive chemotaxis
T	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TFP A 201

Chain	Residue
A	SER44
C	PHE89
C	PHE93
C	TFP201
A	PHE45
A	LEU46
A	GLY47
A	MET85
A	CYS86
A	PHE93
A	TFP202
A	HOH1958

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 301

Chain	Residue
A	SER20
A	GLU23
A	ASP25
A	LYS28
A	GLU33
A	HOH482

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 302

Chain	Residue
A	ASP63
A	ASN65
A	ASP67
A	GLU69
A	GLU74
A	HOH1700

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE TFP J 202

Chain	Residue
A	ASP10
A	SER14
B	PHE89
I	GLU6
I	ASP10
I	HOH404
J	SER44
J	PHE45
J	ILE82
J	CYS86
J	TFP201

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 301

Chain	Residue
B	SER20
B	GLU23
B	ASP25
B	LYS28
B	GLU33
B	HOH162

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 302

Chain	Residue
B	ASP63
B	ASN65
B	ASP67
B	GLU69
B	GLU74
B	HOH1213

---

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE TFP B 201

Chain	Residue
B	SER44
B	PHE45
B	LEU46
B	GLY47
B	MET85
B	PHE89
B	PHE93
B	TFP202
J	PHE89
J	PHE93
J	TFP201

---

site_id	AC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE TFP C 202

Chain	Residue
A	PHE89
A	TFP202
B	ASP10
B	SER14
C	SER44
C	PHE45
C	ILE82
C	CYS86
C	TFP201
D	GLU6
D	HOH1957

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 301

Chain	Residue
C	SER20
C	GLU23
C	ASP25
C	LYS28
C	GLU33
C	HOH291

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 302

Chain	Residue
C	ASP63
C	ASN65
C	ASP67
C	GLU69
C	GLU74
C	HOH1841

---

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE TFP C 201

Chain	Residue
A	PHE89
A	PHE93
A	TFP201
C	SER44
C	PHE45
C	LEU46
C	MET85
C	PHE93
C	TFP202

---

site_id	BC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE TFP E 202

Chain	Residue
E	TFP201
F	GLU6
F	ASP10
F	HOH1730
C	ASP10
C	SER14
D	PHE89
D	TFP202
E	LEU42
E	SER44
E	PHE45
E	CYS86
E	PHE89

---

site_id	BC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE TFP A 202

Chain	Residue
A	LEU42
A	SER44
A	PHE45
A	ILE82
A	TFP201
B	GLU6
B	ASP10
B	HOH1839
C	TFP202
D	ASP10
D	SER14

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 301

Chain	Residue
D	SER20
D	GLU23
D	ASP25
D	LYS28
D	GLU33
D	HOH1233

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 302

Chain	Residue
D	ASP63
D	ASN65
D	ASP67
D	GLU69
D	GLU74
D	HOH230

---

site_id	BC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE TFP D 201

Chain	Residue
D	SER44
D	PHE45
D	GLY47
D	MET85
D	PHE93
D	TFP202
E	PHE89
E	PHE90
E	PHE93
E	TFP201

---

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 301

Chain	Residue
E	SER20
E	GLU23
E	ASP25
E	LYS28
E	GLU33
E	HOH153

---

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 302

Chain	Residue
E	ASP63
E	ASN65
E	ASP67
E	GLU69
E	GLU74
E	HOH1217

---

site_id	CC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TFP E 201

Chain	Residue
D	PHE89
D	PHE90
D	PHE93
D	TFP201
E	SER44
E	PHE45
E	LEU46
E	MET85
E	CYS86
E	PHE89
E	PHE93
E	TFP202

---

site_id	CC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TFP G 202

Chain	Residue
E	ASP10
E	SER14
F	PHE89
F	TFP202
G	SER44
G	PHE45
G	ILE82
G	CYS86
G	PHE89
G	TFP201
H	GLU6
H	ASP10

---

site_id	CC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE TFP D 202

Chain	Residue
C	GLU6
C	ASP10
D	SER44
D	PHE45
D	ILE82
D	CYS86
D	PHE89
D	TFP201
E	TFP202
F	ASP10
F	SER14

---

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA F 301

Chain	Residue
F	SER20
F	GLU23
F	ASP25
F	LYS28
F	GLU33

---

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA F 302

Chain	Residue
F	ASP63
F	ASN65
F	ASP67
F	GLU69
F	GLU74

---

site_id	CC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE TFP F 201

Chain	Residue
F	SER44
F	PHE45
F	LEU46
F	MET85
F	PHE89
F	PHE93
F	TFP202
G	PHE89
G	TFP201

---

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA G 301

Chain	Residue
G	SER20
G	GLU23
G	ASP25
G	LYS28
G	GLU33
G	HOH1975

---

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA G 302

Chain	Residue
G	ASP63
G	ASN65
G	ASP67
G	GLU69
G	GLU74
G	HOH1614

---

site_id	CC9
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TFP G 201

Chain	Residue
F	PHE89
F	PHE93
F	TFP201
G	SER44
G	PHE45
G	LEU46
G	GLY47
G	CYS81
G	MET85
G	PHE89
G	PHE93
G	TFP202

---

site_id	DC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE TFP I 202

Chain	Residue
G	ASP10
H	PHE89
I	SER44
I	PHE45
I	CYS86
I	PHE89
I	TFP201
J	GLU6
J	HOH304

---

site_id	DC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE TFP F 202

Chain	Residue
E	GLU6
F	SER44
F	PHE45
F	ILE82
F	CYS86
F	PHE89
F	TFP201
G	TFP202
H	ASP10
H	HOH102

---

site_id	DC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA H 301

Chain	Residue
H	SER20
H	GLU23
H	ASP25
H	LYS28
H	GLU33

---

site_id	DC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA H 302

Chain	Residue
H	ASP63
H	ASN65
H	ASP67
H	GLU69
H	GLU74

---

site_id	DC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE TFP H 201

Chain	Residue
H	SER44
H	PHE45
H	LEU46
H	ILE82
H	MET85
H	PHE89
H	TFP202
I	PHE89
I	PHE93
I	TFP201

---

site_id	DC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE TFP B 202

Chain	Residue
A	GLU6
A	HOH169
B	SER44
B	PHE45
B	ILE82
B	CYS86
B	PHE89
B	TFP201
I	ASP10
I	SER14

---

site_id	DC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA I 301

Chain	Residue
I	SER20
I	GLU23
I	ASP25
I	LYS28
I	GLU33
I	HOH275

---

site_id	DC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA I 302

Chain	Residue
I	ASP63
I	ASN65
I	ASP67
I	GLU69
I	GLU74
I	HOH1189

---

site_id	DC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE TFP I 201

Chain	Residue
H	PHE89
H	TFP201
I	SER44
I	PHE45
I	LEU46
I	GLY47
I	MET85
I	PHE93
I	TFP202

---

site_id	EC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE TFP H 202

Chain	Residue
G	GLU6
G	ASP10
H	SER44
H	PHE45
H	ILE82
H	CYS86
H	TFP201
I	PHE89
J	ASP10
J	SER14
J	HOH175

---

site_id	EC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA J 301

Chain	Residue
J	SER20
J	GLU23
J	ASP25
J	LYS28
J	GLU33
J	HOH293

---

site_id	EC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA J 302

Chain	Residue
J	ASP63
J	ASN65
J	ASP67
J	GLU69
J	GLU74
J	HOH1610

---

site_id	EC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE TFP J 201

Chain	Residue
B	PHE89
B	PHE90
B	PHE93
B	TFP201
J	SER44
J	PHE45
J	LEU46
J	GLY47
J	CYS81
J	MET85
J	PHE89
J	PHE93
J	TFP202

---

site_id	EC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA K 301

Chain	Residue
K	SER20
K	GLU23
K	ASP25
K	LYS28
K	GLU33
K	HOH160

---

site_id	EC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA K 302

Chain	Residue
K	ASP63
K	ASN65
K	ASP67
K	GLU69
K	GLU74
K	HOH1835

---

site_id	EC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TFP K 201

Chain	Residue
K	SER44
K	PHE45
K	GLY47
K	MET85
K	CYS86
K	PHE89
K	PHE93
K	TFP202
S	PHE89
S	PHE90
S	PHE93
S	TFP201

---

site_id	EC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TFP K 202

Chain	Residue
K	LEU42
K	SER44
K	PHE45
K	ILE82
K	PHE89
K	TFP201
L	GLU6
L	ASP10
L	HOH884
S	PHE89
S	TFP202
T	ASP10

---

site_id	EC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE TFP N 202

Chain	Residue
K	ASP10
K	SER14
L	PHE89
M	GLU6
N	SER44
N	PHE45
N	ILE82
N	PHE89
N	TFP201

---

site_id	FC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA L 301

Chain	Residue
L	SER20
L	GLU23
L	ASP25
L	LYS28
L	GLU33
L	HOH874

---

site_id	FC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA L 302

Chain	Residue
L	ASP63
L	ASN65
L	ASP67
L	GLU69
L	GLU74
L	HOH2718

---

site_id	FC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TFP L 201

Chain	Residue
L	SER44
L	PHE45
L	LEU46
L	GLY47
L	MET85
L	CYS86
L	PHE89
L	PHE93
L	TFP202
N	PHE89
N	PHE93
N	TFP201

---

site_id	FC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TFP S 202

Chain	Residue
K	TFP202
L	ASP10
L	SER14
L	HOH748
S	LEU42
S	SER44
S	PHE45
S	ILE82
S	CYS86
S	TFP201
T	GLU6
T	ASP10

---

site_id	FC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE TFP L 202

Chain	Residue
K	GLU6
K	ASP10
L	SER44
L	PHE45
L	ILE82
L	CYS86
L	TFP201
M	ASP10
M	SER14
M	HOH1699

---

site_id	FC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA M 301

Chain	Residue
M	SER20
M	GLU23
M	ASP25
M	LYS28
M	GLU33

---

site_id	FC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA M 302

Chain	Residue
M	ASP63
M	ASN65
M	ASP67
M	GLU69
M	GLU74
M	HOH1639

---

site_id	FC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE TFP M 201

Chain	Residue
M	SER44
M	PHE45
M	GLY47
M	MET85
M	CYS86
M	PHE89
M	TFP202
P	PHE89
P	PHE93
P	TFP201

---

site_id	FC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA N 301

Chain	Residue
N	SER20
N	GLU23
N	ASP25
N	LYS28
N	GLU33
N	HOH481

---

site_id	GC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA N 302

Chain	Residue
N	ASP63
N	ASN65
N	ASP67
N	GLU69
N	GLU74
N	HOH1589

---

site_id	GC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE TFP N 201

Chain	Residue
L	PHE89
L	GLY92
L	PHE93
L	TFP201
N	SER44
N	PHE45
N	LEU46
N	MET85
N	PHE93

---

site_id	GC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE TFP P 202

Chain	Residue
M	PHE89
M	TFP202
N	ASP10
N	SER14
O	GLU6
O	ASP10
O	HOH1063
P	LEU42
P	SER44
P	PHE45
P	ILE82
P	CYS86
P	PHE89
P	TFP201

---

site_id	GC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE TFP M 202

Chain	Residue
M	SER44
M	PHE45
M	ILE82
M	CYS86
M	PHE89
M	TFP201
N	GLU6
N	ASP10
N	HOH521
O	ASP10
O	SER14
P	PHE89
P	TFP202

---

site_id	GC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA O 301

Chain	Residue
O	SER20
O	GLU23
O	ASP25
O	LYS28
O	GLU33
O	HOH2785

---

site_id	GC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA O 302

Chain	Residue
O	ASP63
O	ASN65
O	ASP67
O	GLU69
O	GLU74
O	HOH1955

---

site_id	GC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE TFP O 201

Chain	Residue
O	SER44
O	PHE45
O	GLY47
O	MET85
O	CYS86
O	PHE93
O	TFP202
Q	PHE89
Q	PHE90
Q	PHE93
Q	TFP201

---

site_id	GC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA P 301

Chain	Residue
P	SER20
P	GLU23
P	ASP25
P	LYS28
P	GLU33
P	HOH102

---

site_id	GC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA P 302

Chain	Residue
P	ASP63
P	ASN65
P	ASP67
P	GLU69
P	GLU74
P	HOH514

---

site_id	HC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TFP P 201

Chain	Residue
M	PHE89
M	PHE90
M	PHE93
M	TFP201
P	SER44
P	PHE45
P	LEU46
P	GLY47
P	MET85
P	CYS86
P	PHE93
P	TFP202

---

site_id	HC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TFP Q 202

Chain	Residue
O	PHE89
O	TFP202
P	ASP10
P	SER14
Q	PHE45
Q	ILE82
Q	CYS86
Q	PHE89
Q	TFP201
R	GLU6
R	ASP10
R	HOH1851

---

site_id	HC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA Q 301

Chain	Residue
Q	SER20
Q	GLU23
Q	ASP25
Q	LYS28
Q	GLU33
Q	HOH406

---

site_id	HC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA Q 302

Chain	Residue
Q	ASP63
Q	ASN65
Q	ASP67
Q	GLU69
Q	GLU74

---

site_id	HC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE TFP Q 201

Chain	Residue
O	PHE89
O	PHE90
O	PHE93
O	TFP201
Q	SER44
Q	PHE45
Q	MET85
Q	PHE93
Q	TFP202

---

site_id	HC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE TFP T 202

Chain	Residue
Q	ASP10
Q	SER14
R	PHE89
S	GLU6
S	ASP10
S	HOH697
T	SER44
T	PHE45
T	CYS86
T	PHE89
T	TFP201

---

site_id	HC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TFP O 202

Chain	Residue
O	SER44
O	PHE45
O	ILE82
O	CYS86
O	TFP201
P	GLU6
P	ASP10
P	HOH2692
Q	PHE89
Q	TFP202
R	ASP10
R	SER14

---

site_id	HC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA R 301

Chain	Residue
R	SER20
R	GLU23
R	ASP25
R	LYS28
R	GLU33
R	HOH105

---

site_id	HC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA R 302

Chain	Residue
R	ASP63
R	ASN65
R	ASP67
R	GLU69
R	GLU74
R	HOH1584

---

site_id	IC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE TFP R 201

Chain	Residue
R	SER44
R	PHE45
R	LEU46
R	GLY47
R	MET85
R	PHE93
R	TFP202
T	PHE89
T	GLY92
T	PHE93
T	TFP201

---

site_id	IC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TFP R 202

Chain	Residue
Q	GLU6
Q	ASP10
R	SER44
R	PHE45
R	ILE82
R	CYS86
R	PHE89
R	TFP201
S	ASP10
S	SER14
S	HOH351
T	PHE89

---

site_id	IC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA S 301

Chain	Residue
S	SER20
S	GLU23
S	ASP25
S	LYS28
S	GLU33
S	HOH886

---

site_id	IC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA S 302

Chain	Residue
S	ASP63
S	ASN65
S	ASP67
S	GLU69
S	GLU74
S	HOH1249

---

site_id	IC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TFP S 201

Chain	Residue
K	PHE89
K	PHE90
K	PHE93
K	TFP201
S	SER44
S	PHE45
S	LEU46
S	GLY47
S	MET85
S	PHE89
S	PHE93
S	TFP202

---

site_id	IC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA T 301

Chain	Residue
T	SER20
T	GLU23
T	ASP25
T	LYS28
T	GLU33
T	HOH1982

---

site_id	IC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA T 302

Chain	Residue
T	ASP63
T	ASN65
T	ASP67
T	GLU69
T	GLU74

---

site_id	IC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE TFP T 201

Chain	Residue
R	PHE89
R	PHE93
R	TFP201
T	SER44
T	PHE45
T	GLY47
T	LYS48
T	MET85
T	PHE93
T	TFP202

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DSNRDNEVDfqEY

Chain	Residue	Details
A	ASP63-TYR75

---

site_id	PS00303
Number of Residues	22
Details	S100_CABP S-100/ICaBP type calcium binding protein signature. LMsnLDsnrDnevDFqEYcvFL

Chain	Residue	Details
A	LEU58-LEU79

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	700
Details	Domain: {"description":"EF-hand 1","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	595
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	40
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	100
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"P35466","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	40
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---