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2GX1
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Solution structure and alanine scan of a spider toxin that affects the activation of mammalian sodium channels
分子名称: Neurotoxin magi-5
著者Sabo, J.K, Corzo, G, Bosmans, F, Billen, B, Villegas, E, Tytgat, J, Norton, R.S.
登録日2006-05-08
公開日2006-12-05
最終更新日2022-03-09
実験手法SOLUTION NMR
主引用文献Solution Structure and Alanine Scan of a Spider Toxin That Affects the Activation of Mammalian Voltage-gated Sodium Channels
J.Biol.Chem., 282, 2007
2KGH
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BU of 2kgh by Molmil
Solution structure of Brachyperma ruhnaui toxin 2
分子名称: Venom peptide 2
著者Corzo, G, Bernard, C, Clement, H, Bosmans, F, Tygat, J, Possani, L.D, Darbon, H, Alagon, A.
登録日2009-03-12
公開日2009-12-15
最終更新日2022-03-16
実験手法SOLUTION NMR
主引用文献Insecticidal peptides from the theraposid spider Brachypelma albiceps: an NMR-based model of Ba2.
Biochim.Biophys.Acta, 1794, 2009
1V91
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BU of 1v91 by Molmil
Solution structure of insectidal toxin delta-paluIT2-NH2
分子名称: Delta-palutoxin IT2
著者Ferrat, G, Bosmans, F, Tytgat, J, Pimentel, C, Chagot, B, Nakajima, T, Darbon, H, Corzo, G.
登録日2004-01-19
公開日2005-03-29
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献Solution structure of two insect-specific spider toxins and their pharmacological interaction with the insect voltage-gated Na(+) channel
Proteins, 59, 2005
1V90
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BU of 1v90 by Molmil
Solution structure by NMR means of delta-paluIT1-NH2
分子名称: Delta-palutoxin IT1
著者Ferrat, G, Bosmans, F, Tytgat, J, Pimentel, C, Chagot, B, Nakajima, T, Darbon, H, Corzo, G.
登録日2004-01-19
公開日2005-03-29
最終更新日2024-10-16
実験手法SOLUTION NMR
主引用文献Solution structure of two insect-specific spider toxins and their pharmacological interaction with the insect voltage-gated Na(+) channel
Proteins, 59, 2005
1ZUT
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BU of 1zut by Molmil
Crystal Structure Of Mutant K8DP9SR58K Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch
分子名称: Alpha-like neurotoxin BmK-I, SULFATE ION
著者Ye, X, Bosmans, F, Li, C, Zhang, Y, Wang, D.C, Tytgat, J.
登録日2005-06-01
公開日2006-05-23
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1
J.Mol.Biol., 353, 2005
1ZYW
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Crystal Structure Of Mutant K8DP9SR58KP60G Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch
分子名称: ACETATE ION, Alpha-like neurotoxin BmK-I, SULFATE ION
著者Ye, X, Bosmans, F, Li, C, Zhang, Y, Wang, D.C, Tytgat, J.
登録日2005-06-13
公開日2006-05-23
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1
J.Mol.Biol., 353, 2005
1ZVG
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Crystal Structure Of Mutant K8DP9S Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch
分子名称: Alpha-like neurotoxin BmK-I
著者Ye, X, Bosmans, F, Li, C, Zhang, Y, Wang, D.C, Tytgat, J.
登録日2005-06-02
公開日2006-06-20
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1
J.Mol.Biol., 353, 2005
1ZYV
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Crystal Structure Of Mutant K8DP9SR58KV59G Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch
分子名称: Alpha-like neurotoxin BmK-I
著者Ye, X, Bosmans, F, Li, C, Zhang, Y, Wang, D.C, Tytgat, J.
登録日2005-06-12
公開日2006-05-23
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1
J.Mol.Biol., 353, 2005
1ZU3
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BU of 1zu3 by Molmil
Crystal Structure Of Mutant K8A Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch
分子名称: Alpha-like neurotoxin BmK-I
著者Ye, X, Bosmans, F, Li, C, Zhang, Y, Wang, D.C, Tytgat, J.
登録日2005-05-30
公開日2006-05-23
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.33 Å)
主引用文献Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1
J.Mol.Biol., 353, 2005
1ZVE
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Crystal Structure Of Mutant K8G Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch
分子名称: ACETATE ION, Alpha-like neurotoxin BmK-I
著者Ye, X, Bosmans, F, Li, C, Zhang, Y, Wang, D.C, Tytgat, J.
登録日2005-06-01
公開日2006-05-23
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1
J.Mol.Biol., 353, 2005
6NT4
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Cryo-EM structure of a human-cockroach hybrid Nav channel bound to alpha-scorpion toxin AaH2.
分子名称: (7E,21R,24S)-27-amino-24-hydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaheptacos-7-en-21-yl (9Z,12E)-octadeca-9,12-dienoate, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Clairfeuille, T, Rohou, A, Payandeh, J.
登録日2019-01-28
公開日2019-02-20
最終更新日2021-08-25
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural basis of alpha-scorpion toxin action on Na v channels.
Science, 363, 2019
1NIX
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BU of 1nix by Molmil
THREE DIMENSIONAL SOLUTION STRUCTURE OF HAINANTOXIN-I BY 2D 1H-NMR
分子名称: HAINANTOXIN-I
著者Li, D, Liang, S.
登録日2002-12-29
公開日2003-01-14
最終更新日2017-11-29
実験手法SOLUTION NMR
主引用文献Function and solution structure of hainantoxin-I, a novel insect sodium channel inhibitor from the Chinese bird spider Selenocosmia hainana.
Febs Lett., 555, 2003
5T4R
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BU of 5t4r by Molmil
NMR solution structure of the Nav1.7 selective spider venom-derived peptide Pn3a
分子名称: Mu-theraphotoxin-Pn3a
著者Rosengren, K.J, Armstrong, D.A, Vetter, I.
登録日2016-08-30
公開日2017-09-06
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Pharmacological characterisation of the highly Na V 1.7 selective spider venom peptide Pn3a.
Sci Rep, 7, 2017
5FDY
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BU of 5fdy by Molmil
Crystal structure of the Voltage-gated Sodium Channel Beta 2 subunit extracellular domain, C72A/C75A mutant
分子名称: GLYCEROL, Sodium channel subunit beta-2
著者Das, S, Van Petegem, F.
登録日2015-12-16
公開日2016-03-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Binary architecture of the Nav1.2-beta 2 signaling complex.
Elife, 5, 2016
5FEB
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BU of 5feb by Molmil
Crystal structure of the Voltage-gated Sodium Channel Beta 2 subunit extracellular domain
分子名称: GLYCEROL, Sodium channel subunit beta-2
著者Das, S, Van Petegem, F.
登録日2015-12-16
公開日2016-03-09
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Binary architecture of the Nav1.2-beta 2 signaling complex.
Elife, 5, 2016
4MZ3
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Crystal structure of the voltage-gated sodium channel beta 4 subunit extracellular domain, C131W mutant
分子名称: Sodium channel subunit beta-4
著者Das, S, Van Petegem, F.
登録日2013-09-28
公開日2013-12-04
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.741 Å)
主引用文献Crystallographic insights into sodium-channel modulation by the beta 4 subunit.
Proc.Natl.Acad.Sci.USA, 110, 2013
4MZ2
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Crystal structure of the voltage-gated sodium channel beta 4 subunit extracellular domain
分子名称: Sodium channel subunit beta-4
著者Das, S, Van Petegem, F.
登録日2013-09-28
公開日2013-12-04
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.722 Å)
主引用文献Crystallographic insights into sodium-channel modulation by the beta 4 subunit.
Proc.Natl.Acad.Sci.USA, 110, 2013
6VSV
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Crystal structure of a disease mutant of the Voltage-gated Sodium Channel Beta 4 subunit extracellular domain
分子名称: Sodium channel subunit beta-4
著者Das, S, Van Petegem, F.
登録日2020-02-12
公開日2020-08-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Biophysical Investigation of Sodium Channel Interaction with beta-Subunit Variants Associated with Arrhythmias.
Bioelectricity, 2, 2020
6VRR
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BU of 6vrr by Molmil
Crystal structure of a disease mutant of the Voltage-gated Sodium Channel Beta 2 subunit extracellular domain
分子名称: GLYCEROL, Sodium channel subunit beta-2
著者Das, S, Van Petegem, F.
登録日2020-02-09
公開日2020-08-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Biophysical Investigation of Sodium Channel Interaction with beta-Subunit Variants Associated with Arrhythmias.
Bioelectricity, 2, 2020
2MI5
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BU of 2mi5 by Molmil
Structure of insect-specific sodium channel toxin mu-Dc1a
分子名称: Mu-diguetoxin-Dc1a
著者Bende, N.S, Mobli, M, King, G.F.
登録日2013-12-08
公開日2014-07-23
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a.
Nat Commun, 5, 2014
2MT7
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Solution structure of spider-venom peptide Hs1a
分子名称: Hs1a
著者Klint, J.K, King, G.F, Mobli, M.
登録日2014-08-14
公開日2015-08-19
最終更新日2024-10-09
実験手法SOLUTION NMR
主引用文献Nav1.7 inhibitors normalise mechanical responses in chronic visceral hypersensitivity
To be Published
2M36
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Solution structure of the insecticidal spider-venom peptide Aps III
分子名称: U2-cyrtautoxin-As1a
著者King, G.F, Bende, N.S, Mobli, M.
登録日2013-01-10
公開日2013-03-27
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献The insecticidal neurotoxin Aps III is an atypical knottin peptide that potently blocks insect voltage-gated sodium channels.
Biochem Pharmacol, 85, 2013
2MF3
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SGTX-Sf1a
分子名称: U2-segestritoxin-Sf1a
著者Mobli, M, Bende, N.S, King, G.F.
登録日2013-10-04
公開日2014-10-15
最終更新日2024-10-16
実験手法SOLUTION NMR
主引用文献The insecticidal spider toxin SFI1 is a knottin peptide that blocks the pore of insect voltage-gated sodium channels via a large beta-hairpin loop.
Febs J., 282, 2015
2N8E
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Three-dimensional structure of cyclic PVIIA
分子名称: Kappa-conotoxin PVIIA
著者Kwon, S, Schroeder, C, Craik, D.
登録日2015-10-13
公開日2016-08-24
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide.
Biotechnol.Bioeng., 113, 2016
2MPQ
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Solution structure of the sodium channel toxin Hd1a
分子名称: Hd1a
著者Klint, J.K, Mobli, M, King, G.F.
登録日2014-06-01
公開日2015-03-25
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach.
Br.J.Pharmacol., 172, 2015

 

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