5WKP
 
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5WGB
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5WLW
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7RTK
 | | Structure of the (NIAU)2 complex with N-terminal mutation of ISCU2 Y35D at 2.5 A resolution | | 分子名称: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, ... | | 著者 | Boniecki, M.T, Cygler, M. | | 登録日 | 2021-08-13 | | 公開日 | 2021-08-25 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | The essential function of ISCU2 and its conserved N-terminus in Fe/S cluster biogenesis
To Be Published
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7M8H
 | | Structure of Memo1 C244S metal binding site mutant at 1.75A | | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Boniecki, M.T, Uhlemann, E.E, Dmitriev, O.Y. | | 登録日 | 2021-03-29 | | 公開日 | 2022-04-06 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | MEMO1 binds iron and modulates iron homeostasis in cancer cells.
Elife, 13, 2024
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6WIH
 | | N-terminal mutation of ISCU2 (L35H36) traps Nfs1 Cys loop in the active site of ISCU2 without metal present. Structure of human mitochondrial complex Nfs1-ISCU2(L35H36)-ISD11 with E.coli ACP1 at 1.9 A resolution (NIAU)2. | | 分子名称: | 1,2-ETHANEDIOL, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, Acyl carrier protein, ... | | 著者 | Boniecki, M.T, Cygler, M. | | 登録日 | 2020-04-09 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The essential function of ISCU2 and its conserved N-terminus in Fe/S cluster biogenesis
To Be Published
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7KQ8
 | | Structure of iron bound MEMO1 | | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, FE (II) ION, ... | | 著者 | Boniecki, M.T, Uhlemann, E.E, Dmitriev, O.Y. | | 登録日 | 2020-11-13 | | 公開日 | 2021-11-17 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | MEMO1 binds iron and modulates iron homeostasis in cancer cells.
Elife, 13, 2024
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7L5C
 | | Structure of copper bound MEMO1 | | 分子名称: | 1,2-ETHANEDIOL, COPPER (I) ION, GLYCEROL, ... | | 著者 | Boniecki, M.T, Uhlemann, E.E, Dmitriev, O.Y. | | 登録日 | 2020-12-21 | | 公開日 | 2022-01-19 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | MEMO1 binds iron and modulates iron homeostasis in cancer cells.
Elife, 13, 2024
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6UXE
 | | Structure of the human mitochondrial desulfurase complex Nfs1-ISCU2(M140I)-ISD11 with E.coli ACP1 at 1.57 A resolution showing flexibility of N terminal end of ISCU2 | | 分子名称: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, ... | | 著者 | Boniecki, M.T, Cygler, M. | | 登録日 | 2019-11-07 | | 公開日 | 2019-11-20 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | | 主引用文献 | The essential function of ISCU2 and its conserved N-terminus in Fe/S cluster biogenesis
To Be Published
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6W1D
 | | Structure of human mitochondrial complex Nfs1-ISCU2 (WT)-ISD11 with E.coli ACP1 at 1.8 A resolution (NIAU)2 | | 分子名称: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, ... | | 著者 | Boniecki, M.T, Cygler, M. | | 登録日 | 2020-03-04 | | 公開日 | 2020-03-18 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.795 Å) | | 主引用文献 | The essential function of ISCU2 and its conserved N-terminus in Fe/S cluster biogenesis
To Be Published
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6WI2
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6MCQ
 | | L. pneumophila effector kinase LegK7 in complex with human MOB1A | | 分子名称: | DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, LegK7, ... | | 著者 | Beyrakhova, K.A, Xu, C, Boniecki, M.T, Cygler, M. | | 登録日 | 2018-09-01 | | 公開日 | 2019-09-04 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | TheLegionellakinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6MCP
 | | L. pneumophila effector kinase LegK7 (AMP-PNP bound) in complex with human MOB1A | | 分子名称: | DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, LegK7, ... | | 著者 | Beyrakhova, K.A, Xu, C, Boniecki, M.T, Cygler, M. | | 登録日 | 2018-09-01 | | 公開日 | 2019-09-04 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | TheLegionellakinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation.
Proc.Natl.Acad.Sci.USA, 117, 2020
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5UFK
 | | Structure of the effector protein SidK (lpg0968) from Legionella pneumophila | | 分子名称: | GLYCEROL, effector protein SidK | | 著者 | Beyrakhova, K, Xu, C, Boniecki, M.T, Cygler, M. | | 登録日 | 2017-01-04 | | 公開日 | 2017-05-10 | | 最終更新日 | 2020-01-08 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Molecular basis for the binding and modulation of V-ATPase by a bacterial effector protein.
PLoS Pathog., 13, 2017
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5UF5
 | | Structure of the effector protein SidK (lpg0968) from Legionella pneumophila (domain-swapped dimer) | | 分子名称: | GLYCEROL, effector protein SidK | | 著者 | Beyrakhova, K, Xu, C, Boniecki, M.T, Cygler, M. | | 登録日 | 2017-01-03 | | 公開日 | 2017-05-10 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Molecular basis for the binding and modulation of V-ATPase by a bacterial effector protein.
PLoS Pathog., 13, 2017
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5UAM
 | | Structure of a new family of Polysaccharide lyase PL25-Ulvanlyase. | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ... | | 著者 | Ulaganathan, T.S, Boniecki, M.T, Cygler, M. | | 登録日 | 2016-12-19 | | 公開日 | 2017-03-29 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | New Ulvan-Degrading Polysaccharide Lyase Family: Structure and Catalytic Mechanism Suggests Convergent Evolution of Active Site Architecture.
ACS Chem. Biol., 12, 2017
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3ZIU
 | | Crystal structure of Mycoplasma mobile Leucyl-tRNA Synthetase with Leu-AMS in the active site | | 分子名称: | 5'-O-(L-leucylsulfamoyl)adenosine, GLYCEROL, LEUCYL-TRNA SYNTHETASE | | 著者 | Li, L, Palencia, A, Lukk, T, Li, Z, Luthey-Schulten, Z.A, Cusack, S, Martinis, S.A, Boniecki, M.T. | | 登録日 | 2013-01-10 | | 公開日 | 2013-02-27 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | Leucyl-tRNA Synthetase Editing Domain Functions as a Molecular Rheostat to Control Codon Ambiguity in Mycoplasma Pathogens.
Proc.Natl.Acad.Sci.USA, 110, 2013
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5VOZ
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5VOY
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5FIA
 | | Structure of the effector protein LpiR1 (Lpg0634) from Legionella pneumophila | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, LpiR1 | | 著者 | Beyrakhova, K, van Straaten, K, Cygler, M. | | 登録日 | 2015-12-22 | | 公開日 | 2016-01-27 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural and Functional Investigations of the Effector Protein LpiR1 from Legionella pneumophila.
J.Biol.Chem., 291, 2016
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5JG4
 | | Structure of the effector protein LpiR1 (Lpg0634) from Legionella pneumophila | | 分子名称: | CITRATE ANION, GLYCEROL, PHOSPHATE ION, ... | | 著者 | Beyrakhova, K, van Straaten, K, Cygler, M. | | 登録日 | 2016-04-19 | | 公開日 | 2016-05-04 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural and Functional Investigations of the Effector Protein LpiR1 from Legionella pneumophila.
J.Biol.Chem., 291, 2016
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6DEH
 | | Structure of LpnE Effector Protein from Legionella pneumophila (sp. Philadelphia) | | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, NICKEL (II) ION, ... | | 著者 | Voth, K, Chung, I.Y.W, van Straaten, K.E, Cygler, M. | | 登録日 | 2018-05-11 | | 公開日 | 2018-12-19 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The structure of Legionella effector protein LpnE provides insights into its interaction with Oculocerebrorenal syndrome of Lowe (OCRL) protein.
FEBS J., 286, 2019
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5UAS
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5VOX
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