6MCQ

L. pneumophila effector kinase LegK7 in complex with human MOB1A

Summary for 6MCQ

Entry DOI	10.2210/pdb6mcq/pdb
Related	6MCP
Descriptor	LegK7, MOB kinase activator 1A, DI(HYDROXYETHYL)ETHER, ... (7 entities in total)
Functional Keywords	translocated effector, ser/thr protein kinase, allosteric activation, hippo pathway, transferase
Biological source	Legionella pneumophila subsp. pneumophila More
Total number of polymer chains	4
Total formula weight	168354.70
Authors	Beyrakhova, K.A.,Xu, C.,Boniecki, M.T.,Cygler, M. (deposition date: 2018-09-01, release date: 2019-09-04, Last modification date: 2024-03-13)
Primary citation	Lee, P.C.,Beyrakhova, K.,Xu, C.,Boniecki, M.T.,Lee, M.H.,Onu, C.J.,Grishin, A.M.,Machner, M.P.,Cygler, M. TheLegionellakinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation. Proc.Natl.Acad.Sci.USA, 117:14433-14443, 2020 Cited by PubMed: 32513747 DOI: 10.1073/pnas.2000497117 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.57 Å)

Structure validation