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5N88
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BU of 5n88 by Molmil
Crystal structure of antibody bound to viral protein
分子名称: PC4 and SFRS1-interacting protein, VH59 antibody
著者Bao, L, Hannon, C, Cruz-Migoni, A, Ptchelkine, D, Sun, M.-y, Derveni, M, Bunjobpol, W, Chambers, J.S, Simmons, A, Phillips, S.E.V, Rabbitts, T.H.
登録日2017-02-23
公開日2017-12-20
最終更新日2019-10-16
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Intracellular immunization against HIV infection with an intracellular antibody that mimics HIV integrase binding to the cellular LEDGF protein.
Sci Rep, 7, 2017
4GVJ
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BU of 4gvj by Molmil
Tyk2 (JH1) in complex with adenosine di-phosphate
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Non-receptor tyrosine-protein kinase TYK2
著者Liang, J, Abbema, A.V, Bao, L, Barrett, K, Beresini, M, Berezhkovskiy, L, Blair, W, Chang, C, Driscoll, J, Eigenbrot, C, Ghilardi, N, Gibbons, P, Halladay, J, Johnson, A, Kohli, P.B, Lai, Y, Liimatta, M, Mantik, P, Menghrajani, K, Murray, J, Sambrone, A, Shao, Y, Shia, S, Shin, Y, Smith, J, Sohn, S, Stanley, M, Tsui, V, Ultsch, M, Wu, L, Zhang, B, Magnuson, S.
登録日2012-08-30
公開日2013-08-14
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Lead identification of novel and selective TYK2 inhibitors.
Eur.J.Med.Chem., 67, 2013
8IXB
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BU of 8ixb by Molmil
GMPCPP-Alpha1A/Beta2A-microtubule decorated with kinesin seam region
分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-1 heavy chain, ...
著者Zheng, W, Zhao, Q.Y, Diao, L, Bao, L, Cong, Y.
登録日2023-03-31
公開日2023-08-16
最終更新日2023-10-25
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Cryo-EM of alpha-tubulin isotype-containing microtubules revealed a contracted structure of alpha 4A/ beta 2A microtubules.
Acta Biochim.Biophys.Sin., 55, 2023
8IXE
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GMPCPP-Alpha1C/Beta2A-microtubule decorated with kinesin seam region
分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-1 heavy chain, ...
著者Zheng, W, Zhao, Q.Y, Diao, L, Bao, L, Cong, Y.
登録日2023-03-31
公開日2023-08-16
最終更新日2023-10-25
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献Cryo-EM of alpha-tubulin isotype-containing microtubules revealed a contracted structure of alpha 4A/ beta 2A microtubules.
Acta Biochim.Biophys.Sin., 55, 2023
8IXG
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GMPCPP-Alpha4A/Beta2A-microtubule decorated with kinesin seam region
分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-1 heavy chain, ...
著者Zheng, W, Zhao, Q.Y, Diao, L, Bao, L, Cong, Y.
登録日2023-03-31
公開日2023-08-16
最終更新日2023-10-25
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献Cryo-EM of alpha-tubulin isotype-containing microtubules revealed a contracted structure of alpha 4A/ beta 2A microtubules.
Acta Biochim.Biophys.Sin., 55, 2023
8IXD
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BU of 8ixd by Molmil
GMPCPP-Alpha1C/Beta2A-microtubule decorated with kinesin non-seam region
分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-1 heavy chain, ...
著者Zheng, W, Zhao, Q.Y, Diao, L, Bao, L, Cong, Y.
登録日2023-03-31
公開日2023-08-16
最終更新日2023-10-25
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献Cryo-EM of alpha-tubulin isotype-containing microtubules revealed a contracted structure of alpha 4A/ beta 2A microtubules.
Acta Biochim.Biophys.Sin., 55, 2023
8IXA
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BU of 8ixa by Molmil
GMPCPP-Alpha1A/Beta2A-microtubule decorated with kinesin non-seam region
分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-1 heavy chain, ...
著者Zheng, W, Zhao, Q.Y, Diao, L, Bao, L, Cong, Y.
登録日2023-03-31
公開日2023-08-16
最終更新日2023-10-25
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Cryo-EM of alpha-tubulin isotype-containing microtubules revealed a contracted structure of alpha 4A/ beta 2A microtubules.
Acta Biochim.Biophys.Sin., 55, 2023
8IXF
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BU of 8ixf by Molmil
GMPCPP-Alpha4A/Beta2A-microtubule decorated with kinesin non-seam region
分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-1 heavy chain, ...
著者Zheng, W, Zhao, Q.Y, Diao, L, Bao, L, Cong, Y.
登録日2023-03-31
公開日2023-08-16
最終更新日2023-10-25
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献Cryo-EM of alpha-tubulin isotype-containing microtubules revealed a contracted structure of alpha 4A/ beta 2A microtubules.
Acta Biochim.Biophys.Sin., 55, 2023
7WNT
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BU of 7wnt by Molmil
RNase J from Mycobacterium tuberculosis
分子名称: Ribonuclease J, ZINC ION
著者Li, J, Bao, L, Hu, J, Zhan, B, Li, Z.
登録日2022-01-19
公開日2023-01-25
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.44 Å)
主引用文献Structural ans functional study of RNase J from Mycobacterium tuberculosis
To Be Published
7WNU
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Mycobacterium tuberculosis Rnase J complex with 7nt RNA
分子名称: RNA (5'-R(P*AP*AP*AP*AP*AP*AP*A)-3'), Ribonuclease J, ZINC ION
著者Li, J, Hu, J, Bao, L, Zhan, B, Li, Z.
登録日2022-01-19
公開日2023-01-25
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural ans functional study of RNase J from Mycobacterium tuberculosis
To Be Published
5H8E
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BU of 5h8e by Molmil
Crystal structure of CK2 with compound 7h
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Casein kinase II subunit alpha, ...
著者Ferguson, A.D.
登録日2015-12-23
公開日2016-02-10
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo.
Acs Med.Chem.Lett., 7, 2016
4Z5S
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BU of 4z5s by Molmil
Crystal structure of apo-form of aldehyde deformylating oxygenase from Synechocystis sp.PCC 6803
分子名称: Aldehyde decarbonylase
著者Jia, C, Li, M, Chang, W.
登録日2015-04-03
公開日2016-04-06
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.582 Å)
主引用文献Identification of residues important for the activity of aldehyde-deformylating oxygenase through investigation into the structure-activity relationship
BMC Biotechnol., 17, 2017
6BSK
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BU of 6bsk by Molmil
Human PIM1 kinase in complex with compound 12b
分子名称: 1,2-ETHANEDIOL, 4-{6-[6-(propan-2-ylamino)-1H-indazol-1-yl]pyrazin-2-yl}benzoic acid, SULFATE ION, ...
著者Ferguson, A.D.
登録日2017-12-03
公開日2018-03-21
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.573 Å)
主引用文献Discovery of 2,6-disubstituted pyrazine derivatives as inhibitors of CK2 and PIM kinases.
Bioorg. Med. Chem. Lett., 28, 2018
6LXT
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BU of 6lxt by Molmil
Structure of post fusion core of 2019-nCoV S2 subunit
分子名称: Spike protein S2, TETRAETHYLENE GLYCOL, ZINC ION
著者Zhu, Y, Sun, F.
登録日2020-02-11
公開日2020-02-26
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion.
Cell Res., 30, 2020
3TL5
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BU of 3tl5 by Molmil
Discovery of GDC-0980: a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor for the Treatment of Cancer
分子名称: (2S)-1-(4-{[2-(2-aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl}piperazin-1-yl)-2-hydroxypropan-1-one, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
著者Murray, J.M, Wiesmann, C.
登録日2011-08-29
公開日2011-11-02
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.788 Å)
主引用文献Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer.
J.Med.Chem., 54, 2011
8VW5
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BU of 8vw5 by Molmil
Crystal structure of Cbl-b TKB bound to compound 2
分子名称: CALCIUM ION, E3 ubiquitin-protein ligase CBL-B, MAGNESIUM ION, ...
著者Yu, C, Murray, J, Hsu, P.L.
登録日2024-01-31
公開日2024-07-03
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding.
Acs Med.Chem.Lett., 15, 2024
8VW4
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BU of 8vw4 by Molmil
Crystal structure of Cbl-b TKB bound to compound 26
分子名称: (7-methoxy-2-{2-[(1S,3S,4S)-3-(3-methoxy-2-methyl-5-nitrophenyl)-1-methyl-5-oxo-1,5-dihydroimidazo[1,5-a]pyridin-2(3H)-yl]-2-oxoethoxy}quinolin-8-yl)acetic acid, DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase CBL-B, ...
著者Yu, C, Murray, J, Hsu, P.L.
登録日2024-01-31
公開日2024-07-03
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding.
Acs Med.Chem.Lett., 15, 2024
7BYR
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BU of 7byr by Molmil
BD23-Fab in complex with the S ectodomain trimer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab23-Fab-Heavy Chain, ...
著者Zhu, Q, Wang, G, Xiao, J.
登録日2020-04-24
公開日2020-06-10
最終更新日2021-03-10
実験手法ELECTRON MICROSCOPY (3.84 Å)
主引用文献Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients' B Cells.
Cell, 182, 2020
3U4U
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BU of 3u4u by Molmil
Casein kinase 2 in complex with AZ-Inhibitor
分子名称: 3-{5-(acetylamino)-3-[3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]-1H-indol-1-yl}propanoic acid, CHLORIDE ION, Casein kinase II subunit alpha
著者Larsen, N.A, Dowling, J.
登録日2011-10-10
公開日2012-08-22
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization.
ACS Med Chem Lett, 3, 2012
7C5K
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Crystal Structure of C150S mutant of Glyceraldehyde-3-phosphate-dehydrogenase1 from Escherichia coli complexed with G3P at 2.69 Angstrom resolution
分子名称: 3-PHOSPHOGLYCERIC ACID, GLYCERALDEHYDE-3-PHOSPHATE, Glyceraldehyde-3-phosphate dehydrogenase, ...
著者Zhang, L, Liu, M.R, Bao, L.Y, Yao, Y.C, Bostrom, I.K, Wang, Y.D, Chen, A.Q, Li, J.X, Gu, S.H, Ji, C.N.
登録日2020-05-20
公開日2021-05-26
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Novel Structures of Type 1 Glyceraldehyde-3-phosphate Dehydrogenase from Escherichia coli Provide New Insights into the Mechanism of Generation of 1,3-Bisphosphoglyceric Acid.
Biomolecules, 11, 2021
7C5O
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BU of 7c5o by Molmil
Crystal Structure of H177A mutant of Glyceraldehyde-3-phosphate-dehydrogenase1 from Escherichia coli complexed with NAD at 1.98 Angstrom resolution.
分子名称: CHLORIDE ION, Glyceraldehyde-3-phosphate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
著者Zhang, L, Liu, M.R, Bao, L.Y, Yao, Y.C, Bostrom, I.K, Wang, Y.D, Chen, A.Q, Li, J.X, Gu, S.H, Ji, C.N.
登録日2020-05-20
公開日2021-05-26
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.981 Å)
主引用文献Novel Structures of Type 1 Glyceraldehyde-3-phosphate Dehydrogenase from Escherichia coli Provide New Insights into the Mechanism of Generation of 1,3-Bisphosphoglyceric Acid.
Biomolecules, 11, 2021
7C5P
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Crystal Structure Glyceraldehyde-3-phosphate-dehydrogenase1 from Escherichia coli complexed with G3P at 2.35 Angstrom resolution.
分子名称: CHLORIDE ION, GLYCERALDEHYDE-3-PHOSPHATE, Glyceraldehyde-3-phosphate dehydrogenase, ...
著者Zhang, L, Liu, M.R, Bao, L.Y, Yao, Y.C, Bostrom, I.K, Wang, Y.D, Chen, A.Q, Li, J.X, Gu, S.H, Ji, C.N.
登録日2020-05-20
公開日2021-05-26
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Novel Structures of Type 1 Glyceraldehyde-3-phosphate Dehydrogenase from Escherichia coli Provide New Insights into the Mechanism of Generation of 1,3-Bisphosphoglyceric Acid.
Biomolecules, 11, 2021
7C5J
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BU of 7c5j by Molmil
Crystal Structure of C150A mutant of Glyceraldehyde-3-phosphate dehydrogenase1 from Escherichia coli at 1.98 Angstrom resolution
分子名称: 1,2-ETHANEDIOL, Glyceraldehyde-3-phosphate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Zhang, L, Liu, M.R, Bao, L.Y, Yao, Y.C, Bostrom, I.K, Wang, Y.D, Chen, A.Q, Li, J.X, Gu, S.H, Ji, C.N.
登録日2020-05-20
公開日2021-05-26
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Novel Structures of Type 1 Glyceraldehyde-3-phosphate Dehydrogenase from Escherichia coli Provide New Insights into the Mechanism of Generation of 1,3-Bisphosphoglyceric Acid.
Biomolecules, 11, 2021
7C7K
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Crystal Structure of Thioacyl-Glyceraldehyde-3-phosphate dehydrogenase 1(GAPDH 1) from Escherichia coli at 1.77 Angstrom resolution
分子名称: 1,2-ETHANEDIOL, ACETONE, DI(HYDROXYETHYL)ETHER, ...
著者Zhang, L, Liu, M.R, Bao, L.Y, Yao, Y.C, Bostrom, I.K, Wang, Y.D, Chen, A.Q, Li, J.X, Gu, S.H, Ji, C.N.
登録日2020-05-26
公開日2021-05-26
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Novel Structures of Type 1 Glyceraldehyde-3-phosphate Dehydrogenase from Escherichia coli Provide New Insights into the Mechanism of Generation of 1,3-Bisphosphoglyceric Acid.
Biomolecules, 11, 2021
7C5M
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Crystal Structure of C150A+H177A mutant of Glyceraldehyde-3-phosphate-dehydrogenase1 from Escherichia coli complexed with G3P at 1.8 Angstrom resolution
分子名称: 1,2-ETHANEDIOL, 3-PHOSPHOGLYCERIC ACID, GLYCERALDEHYDE-3-PHOSPHATE, ...
著者Zhang, L, Liu, M.R, Bao, L.Y, Yao, Y.C, Bostrom, I.K, Wang, Y.D, Chen, A.Q, Li, J.X, Gu, S.H, Ji, C.N.
登録日2020-05-20
公開日2021-05-26
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Novel Structures of Type 1 Glyceraldehyde-3-phosphate Dehydrogenase from Escherichia coli Provide New Insights into the Mechanism of Generation of 1,3-Bisphosphoglyceric Acid.
Biomolecules, 11, 2021

 

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