6BSK

Human PIM1 kinase in complex with compound 12b

Summary for 6BSK

Entry DOI	10.2210/pdb6bsk/pdb
Descriptor	Serine/threonine-protein kinase pim-1, 1,2-ETHANEDIOL, 4-{6-[6-(propan-2-ylamino)-1H-indazol-1-yl]pyrazin-2-yl}benzoic acid, ... (5 entities in total)
Functional Keywords	kinase, pim1, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	32719.01
Authors	Ferguson, A.D. (deposition date: 2017-12-03, release date: 2018-03-21, Last modification date: 2023-10-04)
Primary citation	Gingipalli, L.,Block, M.H.,Bao, L.,Cooke, E.,Dakin, L.A.,Denz, C.R.,Ferguson, A.D.,Johannes, J.W.,Larsen, N.A.,Lyne, P.D.,Pontz, T.W.,Wang, T.,Wu, X.,Wu, A.,Zhang, H.J.,Zheng, X.,Dowling, J.E.,Lamb, M.L. Discovery of 2,6-disubstituted pyrazine derivatives as inhibitors of CK2 and PIM kinases. Bioorg. Med. Chem. Lett., 28:1336-1341, 2018 Cited by PubMed: 29559278 DOI: 10.1016/j.bmcl.2018.03.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.573 Å)

Structure validation